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anti-MYBL2 antibody :: Rabbit B MyB Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS176151
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

B MyB (MYBL2), Polyclonal Antibody

 Also Known As   

Anti-B MyB antibody

 Product Synonym Names    Myb-related protein B; v-myb myeloblastosis viral oncogene homolog(avian)-like 2; B-Myb antibody; BMyB antibody; MGC15600 antibody; MYB L2 antibody; Myb related protein B antibody; Myb-like protein 2 antibody; Myb-related protein B antibody; MybB antibody; MYBB_HUMAN antibody; MYBL 2 antibody; MYBL2 antibody; v myb avian myeloblastosis viral oncogene homolog like 2 antibody; v myb myeloblastosis viral oncogene homolog(avian) like 2 antibody; v myb myeloblastosis viral oncogene homolog like 2 antibody
 Product Gene Name   

anti-MYBL2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601415
 3D Structure    ModBase 3D Structure for P10244
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the N-terminus of human B MyB (1-17aa MSRRTRCEDLDELHYQD), identical to the related mouse sequence and different from the related rat sequence by two amino acids.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MYBL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MYBL2 antibody

   Description: Rabbit IgG polyclonal antibody for Myb-related protein B(MYBL2) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.
Background: MYBL2(V-MYB avian myeloblastosis viral oncogene homolog-like 2), also called MYB-RELATED GENE BMYB, is a protein that in humans is encoded by the MYBL2 gene. The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. Barletta et al.(1991) assigned the MYBL2 gene to chromosome Xq13. However, Noben-Trauth et al.(1996) demonstrated that this assignment was an error. Using mouse Mybl2 cDNA clones as probes, they assigned Mybl2 in an interspecific backcross panel to distal mouse chromosome 2. Using human cDNA probes in combination with fluorescence in situ hybridization analysis, they localized MYBL2 to chromosome 20q13.1, a region that is commonly deleted in myeloid disorders and shows high homology of synteny to mouse chromosome 2. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.
 Applications Tested/Suitable for anti-MYBL2 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

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 Testing Data of anti-MYBL2 antibody    anti-MYBL2 antibody Testing Data image
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 Testing Data #2 of anti-MYBL2 antibody    anti-MYBL2 antibody Testing Data #2 image
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 Testing Data #3 of anti-MYBL2 antibody    anti-MYBL2 antibody Testing Data #3 image
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 Testing Data #4 of anti-MYBL2 antibody    anti-MYBL2 antibody Testing Data #4 image
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 Testing Data #5 of anti-MYBL2 antibody    anti-MYBL2 antibody Testing Data #5 image
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NCBI/Uniprot data below describe general gene information for MYBL2. It may not necessarily be applicable to this product.
 NCBI GI #    127584
 NCBI GeneID    4605
 NCBI Accession #    P10244.1 [Other Products]
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 UniProt Primary Accession #    P10244 [Other Products]
 UniProt Secondary Accession #    Q53F07; B2RBS5; B7Z8D9; F8W6N6 [Other Products]
 UniProt Related Accession #    P10244 [Other Products]
 Molecular Weight    75,865 Da
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 NCBI Official Full Name    Myb-related protein B
 NCBI Official Synonym Full Names    v-myb avian myeloblastosis viral oncogene homolog-like 2
 NCBI Official Symbol    MYBL2 [Similar Products]
 NCBI Official Synonym Symbols   
BMYB; B-MYB
[Similar Products]
 NCBI Protein Information    myb-related protein B; myb-like protein 2; v-myb myeloblastosis viral oncogene homolog-like 2
 UniProt Protein Name    Myb-related protein B
 UniProt Synonym Protein Names   
Myb-like protein 2
 Protein Family    Myb-related protein
 UniProt Gene Name    MYBL2 [Similar Products]
 UniProt Synonym Gene Names    BMYB; B-Myb [Similar Products]
 UniProt Entry Name    MYBB_HUMAN
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 NCBI Summary for MYBL2    The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
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 UniProt Comments for MYBL2    B-Myb: a transcription factor involved in cell cycle progression. Phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.

Protein type: Motility/polarity/chemotaxis; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: nucleoplasm

Molecular Function: protein binding; chromatin binding; transcription factor activity

Biological Process: transcription, DNA-dependent; regulation of cell cycle; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; G2/M transition of mitotic cell cycle
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 Research Articles on MYBL2    1. Results show that E7 interacts with the B-Myb, FoxM1 and LIN9 components of this activator complex, leading to cooperative transcriptional activation of mitotic genes in primary cells and E7 recruitment to the corresponding promoters.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MYBL2 antibodyPathways associated with anti-MYBL2 antibody
 Reference Product  PubMed Publications
 E2F1 antibody  >17 publications with MYBL2 and E2F1
 CCND1 antibody  >14 publications with MYBL2 and CCND1
 RBL1 antibody  >12 publications with MYBL2 and RBL1
 E2F4 antibody  >11 publications with MYBL2 and E2F4
 CCNA2 antibody  >8 publications with MYBL2 and CCNA2
 LIN9 antibody  >8 publications with MYBL2 and LIN9
 TFDP1 antibody  >3 publications with MYBL2 and TFDP1
 CDK1 antibody  >3 publications with MYBL2 and CDK1
 CREBBP antibody  >1 publications with MYBL2 and CREBBP
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 G0 And Early G1 Pathway antibodies  G0 And Early G1 Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Gastric Cancer Network 1 Pathway antibodies  Gastric Cancer Network 1 Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Mitotic G1-G1/S Phases Pathway antibodies  Mitotic G1-G1/S Phases Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
Diseases associated with anti-MYBL2 antibodyOrgans/Tissues associated with anti-MYBL2 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >20 publications with MYBL2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >16 publications with MYBL2 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >8 publications with MYBL2 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >6 publications with MYBL2 and Neoplasms, Experimental
 Uterine Neoplasms Antibodies  >6 publications with MYBL2 and Uterine Neoplasms
 Liver Diseases Antibodies  >5 publications with MYBL2 and Liver Diseases
 Prostatic Neoplasms Antibodies  >5 publications with MYBL2 and Prostatic Neoplasms
 Liver Neoplasms Antibodies  >5 publications with MYBL2 and Liver Neoplasms
 Uterine Cervical Neoplasms Antibodies  >4 publications with MYBL2 and Uterine Cervical Neoplasms
 Fibrosis Antibodies  >3 publications with MYBL2 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >17 publications with MYBL2 and Blood
 Liver Antibodies  >11 publications with MYBL2 and Liver
 Muscle Antibodies  >11 publications with MYBL2 and Muscle
 Bone Antibodies  >10 publications with MYBL2 and Bone
 Vascular Antibodies  >9 publications with MYBL2 and Vascular
 Lung Antibodies  >7 publications with MYBL2 and Lung
 Prostate Antibodies  >7 publications with MYBL2 and Prostate
 Bone Marrow Antibodies  >6 publications with MYBL2 and Bone Marrow
 Testis Antibodies  >6 publications with MYBL2 and Testis
 Brain Antibodies  >5 publications with MYBL2 and Brain
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