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anti-B-actin antibody :: Rabbit B-actin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS668048
Western Blot (WB)
Unit / Price
0.025 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $270 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

B-actin, Polyclonal Antibody

 Also Known As   

B-actin Polyclonal Antibody

 Product Gene Name   

anti-B-actin antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    162091
 3D Structure    ModBase 3D Structure for Q12824
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse (Predicted Reactivity: Rat
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 Form/Format    Purified (Liquid)
 Concentration    0.5mg/ml, 200µl (lot specific)
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 Antigen    B-actin
 Immunogen    A partial recombinant B-actin protein (amino acids 1-200) was used as the immunogen for this antibody.
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 Preparation and Storage    Store antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.
 Other Notes    Small volumes of anti-B-actin antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-B-actin antibody    Misc
 Applications Tested/Suitable for anti-B-actin antibody   

Western Blot (WB)

 Application Notes for anti-B-actin antibody    Western Blot: 4-6 µg/ml
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 Western Blot (WB) of anti-B-actin antibody    Expression analysis of  B-actin. Anti- B-actin antibody (11-13012) was used at 4 µg/ml on (1) Raw, (2) 3T3, (3) Hela and (4) U87 lysates.
anti-B-actin antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for B-actin. It may not necessarily be applicable to this product.
 NCBI GI #    55956801
 NCBI GeneID    6598
 NCBI Accession #    NP_001007469.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001007468.1 [Other Products]
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 UniProt Primary Accession #    Q12824 [Other Products]
 UniProt Secondary Accession #    O75784; O95474; Q17S11; Q38GA1; Q76N08; Q9UBH2 [Other Products]
 UniProt Related Accession #    Q12824; AAB34227 [Other Products]
 Molecular Weight    43,158 Da
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 NCBI Official Full Name    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform b
 NCBI Official Synonym Full Names    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
 NCBI Official Symbol    SMARCB1 [Similar Products]
 NCBI Official Synonym Symbols   
RDT; INI1; SNF5; Snr1; BAF47; MRD15; RTPS1; Sfh1p; hSNFS; SNF5L1; SWNTS1; PPP1R144
[Similar Products]
 NCBI Protein Information    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; BRG1-associated factor 47; SNF5 homolog; SWI/SNF-related matrix-associated protein; hSNF5; integrase interactor 1 protein; malignant rhabdoid tumor suppressor; protein phosphatase 1, regulatory subunit 144; sucrose nonfermenting, yeast, homolog-like 1
 UniProt Protein Name    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
 UniProt Synonym Protein Names   
BRG1-associated factor 47; BAF47; Integrase interactor 1 protein; SNF5 homolog; hSNF5
 UniProt Gene Name    SMARCB1 [Similar Products]
 UniProt Synonym Gene Names    BAF47; INI1; SNF5L1; BAF47; hSNF5 [Similar Products]
 UniProt Entry Name    SNF5_HUMAN
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 NCBI Summary for B-actin    The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for B-actin    SMARCB1: a core component of the BAF (hSWI/SNF) complex. This family of complexes remodels chromatin structures, enabling transcription factors to gain access to DNA. They play important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling is due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4. Involved in activation of CSF1 promoter. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain BAF53A and PHF10, are exchanged for homologous alternative BAF53B and BAF45B or BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand- bound VDR-mediated transrepression of the CYP27B1 gene. Component of the BAF (hSWI/SNF) complex, which includes at least actin (ACTB), ARID1A, ARID1B, SMARCA2, SMARCA4, BAF53A, BAF53B, SMARCE1 SMARCC1, SMARCC2, SMARCB1, and one or more of SMARCD1, SMARCD2, or SMARCD3. In muscle cells, the BAF complex also contains DPF3. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Binds to double-stranded DNA. Interacts with EphB4 and MAEL. Interacts with GADD34. Binds tightly to the human immunodeficiency virus-type 1 (HIV-1) integrase in vitro and stimulates its DNA-joining activity. Interacts with human papillomavirus 18 E1 protein to stimulates its viral replication. Belongs to the SNF5 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; Cell cycle regulation; Tumor suppressor

Chromosomal Location of Human Ortholog: 22q11.23|22q11

Cellular Component: XY body; nucleoplasm; SWI/SNF complex; protein complex; nuclear chromatin; nucleolus; nucleus

Molecular Function: protein binding; nucleosomal DNA binding; Tat protein binding; p53 binding; transcription coactivator activity

Biological Process: nervous system development; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; DNA integration; DNA repair; chromatin remodeling; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; nucleosome disassembly; blastocyst hatching; ATP-dependent chromatin remodeling; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; cell differentiation

Disease: Mental Retardation, Autosomal Dominant 15; Rhabdoid Tumor Predisposition Syndrome 1; Schwannomatosis 1
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 Research Articles on B-actin    1. INI1-retained Small cell undifferentiated may be not prognostically unfavorable
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-B-actin antibodyPathways associated with anti-B-actin antibody
 Reference Product  PubMed Publications
 SMARCA4 antibody  >57 publications with B-actin and SMARCA4
 SMARCA2 antibody  >23 publications with B-actin and SMARCA2
 ARID1A antibody  >22 publications with B-actin and ARID1A
 SMARCE1 antibody  >13 publications with B-actin and SMARCE1
 ARID1B antibody  >11 publications with B-actin and ARID1B
 SMARCC1 antibody  >10 publications with B-actin and SMARCC1
 SMARCD3 antibody  >2 publications with B-actin and SMARCD3
 SMARCD1 antibody  >2 publications with B-actin and SMARCD1
 SMARCC2 antibody  >2 publications with B-actin and SMARCC2
 SMARCD2 antibody  >1 publications with B-actin and SMARCD2
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 RMTs Methylate Histone Arginines Pathway antibodies  RMTs Methylate Histone Arginines Pathway Diagram
 Regulation Of Retinoblastoma Protein Pathway antibodies  Regulation Of Retinoblastoma Protein Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
Diseases associated with anti-B-actin antibodyOrgans/Tissues associated with anti-B-actin antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >41 publications with B-actin and Kidney Diseases
 Musculoskeletal Diseases Antibodies  >28 publications with B-actin and Musculoskeletal Diseases
 Liver Neoplasms Antibodies  >16 publications with B-actin and Liver Neoplasms
 Liver Diseases Antibodies  >13 publications with B-actin and Liver Diseases
 Neoplasm Metastasis Antibodies  >12 publications with B-actin and Neoplasm Metastasis
 Coffin-Siris syndrome Antibodies  >11 publications with B-actin and Coffin-Siris syndrome
 Necrosis Antibodies  >10 publications with B-actin and Necrosis
 Lung Neoplasms Antibodies  >10 publications with B-actin and Lung Neoplasms
 Heart Diseases Antibodies  >9 publications with B-actin and Heart Diseases
 Prostatic Diseases Antibodies  >3 publications with B-actin and Prostatic Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >134 publications with B-actin and Brain
 Kidney Antibodies  >69 publications with B-actin and Kidney
 Blood Antibodies  >47 publications with B-actin and Blood
 Nerve Antibodies  >33 publications with B-actin and Nerve
 Skin Antibodies  >30 publications with B-actin and Skin
 Liver Antibodies  >20 publications with B-actin and Liver
 Bone Antibodies  >18 publications with B-actin and Bone
 Muscle Antibodies  >16 publications with B-actin and Muscle
 Lung Antibodies  >13 publications with B-actin and Lung
 Embryonic Tissue Antibodies  >11 publications with B-actin and Embryonic Tissue
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