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anti-BCL10 antibody :: Rabbit anti-Human B-cell lymphoma/leukemia 10 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7005827
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

B-cell lymphoma/leukemia 10 (BCL10), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human B-cell lymphoma/leukemia 10 polyclonal Antibody

 Product Synonym Names    Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; cCARMEN; Cellular-E10; c-E10; mE10; BCL10; CIPER; CLAP
 Product Gene Name   

anti-BCL10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603517
 3D Structure    ModBase 3D Structure for O95999
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human B-cell lymphoma/leukemia 10 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9558 / sc-9560 / sc-55511 / sc-5611
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-BCL10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BCL10 antibody

   Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. This protein contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
 Product Categories/Family for anti-BCL10 antibody    Apoptosis
 Applications Tested/Suitable for anti-BCL10 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-BCL10 antibody    Recommended dilution: IHC: 1:20-1:200
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 Immunohistochemistry (IHC) of anti-BCL10 antibody    Immunohistochemistry of paraffin-embedded human lung tissue using MBS7005827 at dilution 1:100
anti-BCL10 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-BCL10 antibody    Immunohistochemistry of paraffin-embedded human ovarian cancer using MBS7005827 at dilution 1:100
anti-BCL10 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-BCL10 antibody    Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7005827 at dilution 1:100
anti-BCL10 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for BCL10. It may not necessarily be applicable to this product.
 NCBI GI #    4502379
 NCBI GeneID    8915
 NCBI Accession #    NP_003912.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003921.4 [Other Products]
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 UniProt Primary Accession #    O95999 [Other Products]
 UniProt Secondary Accession #    Q5VUF1 [Other Products]
 UniProt Related Accession #    O95999 [Other Products]
 Molecular Weight    26,252 Da
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 NCBI Official Full Name    B-cell lymphoma/leukemia 10
 NCBI Official Synonym Full Names    B-cell CLL/lymphoma 10
 NCBI Official Symbol    BCL10 [Similar Products]
 NCBI Official Synonym Symbols   
CLAP; mE10; CIPER; IMD37; c-E10; CARMEN
[Similar Products]
 NCBI Protein Information    B-cell lymphoma/leukemia 10
 UniProt Protein Name    B-cell lymphoma/leukemia 10
 UniProt Synonym Protein Names   
B-cell CLL/lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; Cellular homolog of vCARMEN; cCARMEN; Cellular-E10; c-E10; Mammalian CARD-containing adapter molecule E10; mE10
 Protein Family    B-cell lymphoma/leukemia
 UniProt Gene Name    BCL10 [Similar Products]
 UniProt Synonym Gene Names    CIPER; CLAP; Bcl-10; hCLAP; CIPER; cCARMEN; c-E10; mE10 [Similar Products]
 UniProt Entry Name    BCL10_HUMAN
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 NCBI Summary for BCL10    This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BCL10    Bcl-10: a ubiquitous pro-apoptotic protein that promotes pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Self-associates via CARD-CARD interactions; forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Defects in BCL10 are involved in various types of cancer.

Protein type: Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: CBM complex; cytoplasm; cytoplasmic microtubule; cytosol; immunological synapse; lipid raft; lipopolysaccharide receptor complex; lysosome; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; T cell receptor complex

Molecular Function: enzyme binding; kinase activator activity; kinase binding; NF-kappaB binding; protease binding; protein binding; protein C-terminus binding; protein kinase B binding; protein kinase binding; protein self-association; transcription coactivator activity; transcription factor binding; ubiquitin binding; ubiquitin protein ligase binding

Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; B cell apoptosis; cell death; cellular defense response; immunoglobulin mediated immune response; innate immune response; interleukin-6 biosynthetic process; lymphotoxin A biosynthetic process; negative regulation of mature B cell apoptosis; neural tube closure; positive regulation of caspase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 biosynthetic process; positive regulation of mast cell cytokine production; positive regulation of phosphorylation; positive regulation of protein ubiquitination; positive regulation of T cell activation; positive regulation of transcription, DNA-dependent; protein heterooligomerization; protein homooligomerization; protein oligomerization; regulation of T cell receptor signaling pathway; response to food; response to fungus; response to molecule of bacterial origin; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; toll-like receptor signaling pathway

Disease: Follicular Lymphoma, Susceptibility To, 1; Gastric Lymphoma, Primary; Immunodeficiency 37; Lymphoma, Non-hodgkin, Familial; Mesothelioma, Malignant; Testicular Germ Cell Tumor
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 Research Articles on BCL10    1. The results of this study indicate that inherited BCL10 deficiency should be considered in patients with combined immunodeficiency with B cell, T cell, and fibroblast defects.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BCL10 antibodyPathways associated with anti-BCL10 antibody
 Reference Product  PubMed Publications
 MALT1 antibody  >238 publications with BCL10 and MALT1
 CARD11 antibody  >110 publications with BCL10 and CARD11
 IKBKB antibody  >57 publications with BCL10 and IKBKB
 CARD9 antibody  >35 publications with BCL10 and CARD9
 CARD10 antibody  >23 publications with BCL10 and CARD10
 PRKCQ antibody  >20 publications with BCL10 and PRKCQ
 CHUK antibody  >19 publications with BCL10 and CHUK
 IKBKG antibody  >7 publications with BCL10 and IKBKG
 RIPK2 antibody  >5 publications with BCL10 and RIPK2
 BIRC3 antibody  >1 publications with BCL10 and BIRC3
 Products by Pathway  Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 C-type Lectin Receptors (CLRs) Pathway antibodies  C-type Lectin Receptors (CLRs) Pathway Diagram
 CLEC7A (Dectin-1) Signaling Pathway antibodies  CLEC7A (Dectin-1) Signaling Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
Diseases associated with anti-BCL10 antibodyOrgans/Tissues associated with anti-BCL10 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >208 publications with BCL10 and Immune System Diseases
 Inflammation Antibodies  >49 publications with BCL10 and Inflammation
 Necrosis Antibodies  >42 publications with BCL10 and Necrosis
 Nervous System Diseases Antibodies  >14 publications with BCL10 and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >14 publications with BCL10 and Cell Transformation, Neoplastic
 Cardiovascular Diseases Antibodies  >11 publications with BCL10 and Cardiovascular Diseases
 Lung Diseases Antibodies  >11 publications with BCL10 and Lung Diseases
 Breast Neoplasms Antibodies  >9 publications with BCL10 and Breast Neoplasms
 Brain Diseases Antibodies  >9 publications with BCL10 and Brain Diseases
 Lung Neoplasms Antibodies  >9 publications with BCL10 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >153 publications with BCL10 and Blood
 Stomach Antibodies  >41 publications with BCL10 and Stomach
 Lung Antibodies  >19 publications with BCL10 and Lung
 Intestine Antibodies  >18 publications with BCL10 and Intestine
 Lymph Node Antibodies  >16 publications with BCL10 and Lymph Node
 Spleen Antibodies  >16 publications with BCL10 and Spleen
 Liver Antibodies  >15 publications with BCL10 and Liver
 Skin Antibodies  >14 publications with BCL10 and Skin
 Bone Antibodies  >13 publications with BCL10 and Bone
 Brain Antibodies  >12 publications with BCL10 and Brain
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