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anti-MS4A1 antibody :: Rabbit anti-Human B-lymphocyte antigen CD20 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS969007
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

B-lymphocyte antigen CD20 (MS4A1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human B-lymphocyte antigen CD20 polyclonal Antibody(MS4A1)

 Product Synonym Names    B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD20; MS4A1
 Product Gene Name   

anti-MS4A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    112210
 3D Structure    ModBase 3D Structure for P11836
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human B-lymphocyte antigen CD20 protein (208-297aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7735 / sc-7733 / sc-15361
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MS4A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MS4A1 antibody

   This protein may be involved in the regulation of B-cell activation and proliferation.
 Applications Tested/Suitable for anti-MS4A1 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-MS4A1 antibody    Recommended dilution: IHC:1:20-1:200
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 Immunohistochemistry (IHC) of anti-MS4A1 antibody    Immunohistochemistry of paraffin-embedded human tonsil using MBS969007 at dilution 1:100
anti-MS4A1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MS4A1 antibody    Immunohistochemistry of paraffin-embedded human epityphlon using MBS969007 at dilution 1:100
anti-MS4A1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MS4A1. It may not necessarily be applicable to this product.
 NCBI GI #    23110987
 NCBI GeneID    931
 NCBI Accession #    NP_068769.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_021950.3 [Other Products]
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 UniProt Primary Accession #    P11836 [Other Products]
 UniProt Secondary Accession #    P08984; Q13963; A6NMS4; B4DT24 [Other Products]
 UniProt Related Accession #    P11836 [Other Products]
 Molecular Weight    14,581 Da
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 NCBI Official Full Name    B-lymphocyte antigen CD20
 NCBI Official Synonym Full Names    membrane spanning 4-domains A1
 NCBI Official Symbol    MS4A1 [Similar Products]
 NCBI Official Synonym Symbols   
B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16
[Similar Products]
 NCBI Protein Information    B-lymphocyte antigen CD20
 UniProt Protein Name    B-lymphocyte antigen CD20
 UniProt Synonym Protein Names   
B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20
 Protein Family    B-lymphocyte antigen
 UniProt Gene Name    MS4A1 [Similar Products]
 UniProt Synonym Gene Names    CD20 [Similar Products]
 UniProt Entry Name    CD20_HUMAN
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 NCBI Summary for MS4A1    This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MS4A1    MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family.

Protein type: Membrane protein, integral; Cell surface; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: external side of plasma membrane; extracellular space; integral to plasma membrane

Molecular Function: epidermal growth factor receptor binding; protein binding

Biological Process: B cell proliferation; humoral immune response

Disease: Immunodeficiency, Common Variable, 5
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 Research Articles on MS4A1    1. Characterize premature human NK/T-cell lymphoma cell line with expression of the B-cell marker CD20.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MS4A1 antibodyPathways associated with anti-MS4A1 antibody
 Reference Product  PubMed Publications
 MS4A3 antibody  >4 publications with MS4A1 and MS4A3
 LCK antibody  >1 publications with MS4A1 and LCK
 MS4A7 antibody  >1 publications with MS4A1 and MS4A7
 Products by Pathway  Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
Diseases associated with anti-MS4A1 antibodyOrgans/Tissues associated with anti-MS4A1 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with MS4A1 and Breast Neoplasms
 Atherosclerosis Antibodies  >1 publications with MS4A1 and Atherosclerosis
 Carcinoma, Squamous Cell Antibodies  >1 publications with MS4A1 and Carcinoma, Squamous Cell
 Lung Diseases Antibodies  >1 publications with MS4A1 and Lung Diseases
 Lung Neoplasms Antibodies  >1 publications with MS4A1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13 publications with MS4A1 and Blood
 Lung Antibodies  >3 publications with MS4A1 and Lung
 Kidney Antibodies  >2 publications with MS4A1 and Kidney
 Pancreas Antibodies  >1 publications with MS4A1 and Pancreas
 Prostate Antibodies  >1 publications with MS4A1 and Prostate
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