AAG60610.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,213 Da
NCBI Official Full Name
B3GALT2
NCBI Official Synonym Full Names
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
NCBI Protein Information
beta-1,3-galactosyltransferase 2; UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2; beta-1,3-GalTase 2; beta-3-galt2
UniProt Protein Name
Beta-1,3-galactosyltransferase 2
UniProt Synonym Protein Names
UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2
UniProt Synonym Gene Names
UniProt Entry Name
B3GT2_HUMAN
NCBI Summary for B3GALT2
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes a protein that functions in N-linked glycoprotein glycosylation and shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008]
UniProt Comments for B3GALT2
B3GALT2: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues. Belongs to the glycosyltransferase 31 family.
Protein type: EC 2.4.1.-; Transferase; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q31
Cellular Component: Golgi membrane; integral to membrane
Molecular Function: UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
Biological Process: oligosaccharide biosynthetic process; protein amino acid glycosylation
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Pathways associated with anti-B3GALT2 antibody
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