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anti-BAAT antibody :: Rabbit anti-Human, Mouse BAAT Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7045598
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BAAT, Polyclonal Antibody

★Popular Item★
 Also Known As   

BAAT Antibody

 Product Synonym Names    Bile acid-CoA:amino acid N-acyltransferase1 Publication; Glycine N-choloyltransferase; Long-chain fatty-acyl-CoA hydrolase; BAAT
 Product Gene Name   

anti-BAAT antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602938
 3D Structure    ModBase 3D Structure for Q14032
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Bile acid-CoA:amino acid N-acyltransferase protein (C-110AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-BAAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BAAT antibody

   Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.
 Applications Tested/Suitable for anti-BAAT antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-BAAT antibody    Western blot
All lanes: BAAT antibody IgG at 3.73ug/ml+ Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 46 kDa
Observed band size: 46 kDa

anti-BAAT antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-BAAT antibody    Immunohistochemistry of paraffin-embedded human lung cancer using MBS7045598 at dilution 1:100
anti-BAAT antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-BAAT antibody    Immunohistochemistry of paraffin-embedded human liver cancer using MBS7045598 at dilution 1:100
anti-BAAT antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for BAAT. It may not necessarily be applicable to this product.
 NCBI GI #    189083866
 NCBI GeneID    570
 NCBI Accession #    NP_001121082.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001127610.1 [Other Products]
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 UniProt Primary Accession #    Q14032 [Other Products]
 UniProt Secondary Accession #    Q3B7W9; Q96L31 [Other Products]
 UniProt Related Accession #    Q14032 [Other Products]
 Molecular Weight    46,299 Da
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 NCBI Official Full Name    bile acid-CoA:amino acid N-acyltransferase
 NCBI Official Synonym Full Names    bile acid-CoA:amino acid N-acyltransferase
 NCBI Official Symbol    BAAT [Similar Products]
 NCBI Official Synonym Symbols   
BAT; BACAT
[Similar Products]
 NCBI Protein Information    bile acid-CoA:amino acid N-acyltransferase
 UniProt Protein Name    Bile acid-CoA:amino acid N-acyltransferase
 UniProt Synonym Protein Names   
Glycine N-choloyltransferase; Long-chain fatty-acyl-CoA hydrolase
 Protein Family    Bile acid-CoA:amino acid N-acyltransferase
 UniProt Gene Name    BAAT [Similar Products]
 UniProt Synonym Gene Names    BAT [Similar Products]
 UniProt Entry Name    BAAT_HUMAN
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 NCBI Summary for BAAT    The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BAAT    BAAT: Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs. Defects in BAAT are involved in familial hypercholanemia (FHCA). FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. Belongs to the C/M/P thioester hydrolase family.

Protein type: Other Amino Acids Metabolism - taurine and hypotaurine; EC 2.3.1.65; EC 3.1.2.2; Lipid Metabolism - unsaturated fatty acid biosynthesis; Hydrolase; Lipid Metabolism - primary bile acid biosynthesis; Transferase

Chromosomal Location of Human Ortholog: 9q22.3

Cellular Component: cytosol; peroxisomal matrix; peroxisome

Molecular Function: glycine N-choloyltransferase activity; N-acyltransferase activity; protein binding; receptor binding; transferase activity, transferring acyl groups

Biological Process: acyl-CoA metabolic process; bile acid biosynthetic process; bile acid metabolic process; glycine metabolic process; taurine metabolic process

Disease: Hypercholanemia, Familial
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 Research Articles on BAAT    1. Case Report: mmunostaining may facilitate diagnosis in bile-acid amidation defects in bile acid-CoA: amino acid N-acyltransferase deficiency.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-BAAT antibodyDiseases associated with anti-BAAT antibody
 Products by Pathway  Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Conjugated Bile Acid Biosynthesis, Cholate => Taurocholate/glycocholate Pathway antibodies  Conjugated Bile Acid Biosynthesis, Cholate => Taurocholate/glycocholate Pathway Diagram
 Conjugated Bile Acid Biosynthesis, Cholate => Taurocholate/glycocholate Pathway antibodies  Conjugated Bile Acid Biosynthesis, Cholate => Taurocholate/glycocholate Pathway Diagram
 Drug Induction Of Bile Acid Pathway antibodies  Drug Induction Of Bile Acid Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >13 publications with BAAT and Liver Diseases
 Fatty Liver Antibodies  >13 publications with BAAT and Fatty Liver
 Fibrosis Antibodies  >11 publications with BAAT and Fibrosis
 Cholestasis Antibodies  >9 publications with BAAT and Cholestasis
 Brain Diseases Antibodies  >6 publications with BAAT and Brain Diseases
 Inflammation Antibodies  >5 publications with BAAT and Inflammation
 Lung Diseases Antibodies  >5 publications with BAAT and Lung Diseases
 Liver Cirrhosis Antibodies  >4 publications with BAAT and Liver Cirrhosis
 Cholestasis, Intrahepatic Antibodies  >4 publications with BAAT and Cholestasis, Intrahepatic
 Atrophy Antibodies  >3 publications with BAAT and Atrophy
Organs/Tissues associated with anti-BAAT antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >29 publications with BAAT and Liver
 Lung Antibodies  >3 publications with BAAT and Lung
 Heart Antibodies  >2 publications with BAAT and Heart
 Muscle Antibodies  >2 publications with BAAT and Muscle
 Skin Antibodies  >2 publications with BAAT and Skin
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