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anti-BACE1 antibody :: Rabbit anti-Human BACE1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7047737
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BACE1, Polyclonal Antibody

★Popular Item★
 Also Known As   

BACE1 Antibody

 Product Synonym Names    Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2; BACE1; BACE; KIAA1149
 Product Gene Name   

anti-BACE1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF190725 mRNA
 3D Structure    ModBase 3D Structure for P56817
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Beta-secretase 1 protein (46-155AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-10053 / sc-10055 / sc-10748
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-BACE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BACE1 antibody

   Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
 Applications Tested/Suitable for anti-BACE1 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-BACE1 antibody    IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Immunohistochemistry (IHC) of anti-BACE1 antibody    Immunohistochemistry of paraffin-embedded human adrenal gland tissue using MBS7047737 at dilution of 1:100
anti-BACE1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-BACE1 antibody    Immunohistochemistry of paraffin-embedded human melanoma cancer using MBS7047737 at dilution of 1:100
anti-BACE1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-BACE1 antibody    Immunofluorescent analysis of A549 cells using MBS7047737 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-BACE1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for BACE1. It may not necessarily be applicable to this product.
 NCBI GI #    333755186
 NCBI GeneID    23621
 NCBI Accession #    NP_001193978.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001207049.1 [Other Products]
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 UniProt Primary Accession #    P56817 [Other Products]
 UniProt Secondary Accession #    Q9BYB9; Q9BYC0; Q9BYC1; Q9UJT5; Q9ULS1; A0M8W7; B0YIU9; E9PE65; H7BXJ9 [Other Products]
 UniProt Related Accession #    P56817 [Other Products]
 Molecular Weight    42,107 Da
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 NCBI Official Full Name    beta-secretase 1 isoform F
 NCBI Official Synonym Full Names    beta-secretase 1
 NCBI Official Symbol    BACE1 [Similar Products]
 NCBI Official Synonym Symbols   
ASP2; BACE; HSPC104
[Similar Products]
 NCBI Protein Information    beta-secretase 1
 UniProt Protein Name    Beta-secretase 1
 UniProt Synonym Protein Names   
Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2
 Protein Family    Beta-secretase
 UniProt Gene Name    BACE1 [Similar Products]
 UniProt Synonym Gene Names    BACE; KIAA1149; ASP2; Asp 2; Beta-site APP cleaving enzyme 1 [Similar Products]
 UniProt Entry Name    BACE1_HUMAN
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 NCBI Summary for BACE1    This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]
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 UniProt Comments for BACE1    BACE: an integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Cleaves APP at the amino terminus of the A-beta peptide sequence, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated carboxy-terminal fragment which is later release by gamma-secretase. Four splice-variant isoforms have been described.

Protein type: EC 3.4.23.46; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 11q23.2-q23.3

Cellular Component: endoplasmic reticulum lumen; endosome; endosome membrane; Golgi apparatus; integral to plasma membrane; late endosome; multivesicular body; plasma membrane; trans-Golgi network

Molecular Function: aspartic-type endopeptidase activity; beta-amyloid binding; beta-aspartyl-peptidase activity; enzyme binding; peptidase activity; protein binding

Biological Process: beta-amyloid metabolic process; cellular protein metabolic process; membrane protein ectodomain proteolysis; protein catabolic process; proteolysis
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 Research Articles on BACE1    1. Review discussing the major discoveries of the past 3 years concerning BACE1 biology and to what extent these could limit the use of BACE1 inhibitors in the clinic
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BACE1 antibodyPathways associated with anti-BACE1 antibody
 Reference Product  PubMed Publications
 APP antibody  >1360 publications with BACE1 and APP
 PSEN1 antibody  >310 publications with BACE1 and PSEN1
 FURIN antibody  >16 publications with BACE1 and FURIN
 GGA1 antibody  >14 publications with BACE1 and GGA1
 LRP1 antibody  >13 publications with BACE1 and LRP1
 SORL1 antibody  >10 publications with BACE1 and SORL1
 NCSTN antibody  >7 publications with BACE1 and NCSTN
 RANBP9 antibody  >6 publications with BACE1 and RANBP9
 ITM2B antibody  >3 publications with BACE1 and ITM2B
 PLSCR1 antibody  >1 publications with BACE1 and PLSCR1
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyloid Fiber Formation Pathway antibodies  Amyloid Fiber Formation Pathway Diagram
 Copper Homeostasis Pathway antibodies  Copper Homeostasis Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
Diseases associated with anti-BACE1 antibodyOrgans/Tissues associated with anti-BACE1 antibody
 Disease Name  Pubmed Publications
 Alzheimer Disease Antibodies  >1506 publications with BACE1 and Alzheimer Disease
 Brain Diseases Antibodies  >1408 publications with BACE1 and Brain Diseases
 Disease Models, Animal Antibodies  >324 publications with BACE1 and Disease Models, Animal
 Memory Disorders Antibodies  >101 publications with BACE1 and Memory Disorders
 Inflammation Antibodies  >84 publications with BACE1 and Inflammation
 Cognition Disorders Antibodies  >82 publications with BACE1 and Cognition Disorders
 Neurobehavioral Manifestations Antibodies  >81 publications with BACE1 and Neurobehavioral Manifestations
 Learning Disorders Antibodies  >77 publications with BACE1 and Learning Disorders
 Necrosis Antibodies  >73 publications with BACE1 and Necrosis
 Nerve Degeneration Antibodies  >30 publications with BACE1 and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1293 publications with BACE1 and Brain
 Blood Antibodies  >230 publications with BACE1 and Blood
 Kidney Antibodies  >90 publications with BACE1 and Kidney
 Vascular Antibodies  >79 publications with BACE1 and Vascular
 Liver Antibodies  >36 publications with BACE1 and Liver
 Muscle Antibodies  >33 publications with BACE1 and Muscle
 Embryonic Tissue Antibodies  >27 publications with BACE1 and Embryonic Tissue
 Ovary Antibodies  >26 publications with BACE1 and Ovary
 Eye Antibodies  >23 publications with BACE1 and Eye
 Ear Antibodies  >20 publications with BACE1 and Ear
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