NP_620429.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,160 Da
NCBI Official Full Name
beta-secretase 1 isoform D
NCBI Official Synonym Full Names
beta-secretase 1
NCBI Protein Information
beta-secretase 1
UniProt Protein Name
Beta-secretase 1
UniProt Synonym Protein Names
Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2
UniProt Synonym Gene Names
NCBI Summary for BACE1
This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]
UniProt Comments for BACE1
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Product References and Citations for anti-BACE1 antibody
(1) Ly, P.T., Wu, Y., Zou, H., et al. Inhibition of GSK3beta-mediated BACE1 expression reduces Alzheimer-associated phenotypes. J. Clin. Invest. 123 (1), 224-235 (2013).
Research Articles on BACE1
Precautions
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Disclaimer
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Products associated with anti-BACE1 antibody
Pathways associated with anti-BACE1 antibody
Diseases associated with anti-BACE1 antibody
Organs/Tissues associated with anti-BACE1 antibody
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