NP_036237.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,476 Da
NCBI Official Full Name
beta-secretase 2 isoform A preproprotein
NCBI Official Synonym Full Names
beta-site APP-cleaving enzyme 2
NCBI Official Synonym Symbols
ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1 [Similar Products]
NCBI Protein Information
beta-secretase 2; 56 kDa aspartic-like protease; Down syndrome region aspartic protease; aspartyl protease 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; memapsin-1; membrane-associated aspartic protease 1; theta-secretase; transmembrane aspartic proteinase Asp1
UniProt Protein Name
Beta-secretase 2
UniProt Synonym Protein Names
Aspartic-like protease 56 kDa; Aspartyl protease 1; ASP1; Asp 1; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; DRAP; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase
UniProt Synonym Gene Names
AEPLC; ALP56; ASP21; ASP1; Asp 1; Beta-site APP cleaving enzyme 2; DRAP [Similar Products]
UniProt Entry Name
BACE2_HUMAN
NCBI Summary for BACE2
This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for BACE2
BACE2: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Belongs to the peptidase A1 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.23.45; Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: Golgi apparatus; cell surface; endoplasmic reticulum; integral to membrane; endosome
Molecular Function: aspartic-type endopeptidase activity
Biological Process: negative regulation of amyloid precursor protein biosynthetic process; membrane protein ectodomain proteolysis; peptide hormone processing; proteolysis
Research Articles on BACE2
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Products associated with anti-BACE2 antibody
Pathways associated with anti-BACE2 antibody
Diseases associated with anti-BACE2 antibody
Organs/Tissues associated with anti-BACE2 antibody
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