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anti-BACE2 antibody :: Rabbit anti-Human, Rat BACE2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7051616
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BACE2, Polyclonal Antibody

★Popular Item★
 Also Known As   

BACE2 Antibody

 Product Synonym Names    Beta-secretase 2; Aspartic-like protease 56 kDa; Aspartyl protease 1; ASP1; Asp 1; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; DRAP; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase; BACE2; AEPLC; ALP56; ASP21; CDA13; UNQ418/PRO852
 Product Gene Name   

anti-BACE2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF200342 mRNA
 3D Structure    ModBase 3D Structure for Q9Y5Z0
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Beta-secretase 2 protein (84-157AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-10048 / sc-10049 / sc-10051 / sc-15388
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-BACE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BACE2 antibody

   Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
 Applications Tested/Suitable for anti-BACE2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-BACE2 antibody    WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-BACE2 antibody    Western Blot
Positive WB detected in: A549 whole cell lysate,HL-60 whole cell lysate,Hela whole cell lysate,SH-SY5Y whole cell lysate,Rat spleen tissue
All lanes: BACE2 antibody at 2.5ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 57,51,43,39,47 KDa
Observed band size: 57,43 KDa

anti-BACE2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-BACE2 antibody    Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7051616 at dilution of 1:100
anti-BACE2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-BACE2 antibody    Immunofluorescent analysis of A549 cells using MBS7051616 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-BACE2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for BACE2. It may not necessarily be applicable to this product.
 NCBI GI #    19923395
 NCBI GeneID    25825
 NCBI Accession #    NP_036237.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012105.4 [Other Products]
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 UniProt Primary Accession #    Q9Y5Z0 [Other Products]
 UniProt Secondary Accession #    Q5DIH8; Q8N2D4; Q9H2V8; Q9NZL1; Q9NZL2; Q9UJT6; A8K7P1 [Other Products]
 UniProt Related Accession #    Q9Y5Z0 [Other Products]
 Molecular Weight    46,476 Da
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 NCBI Official Full Name    beta-secretase 2 isoform A preproprotein
 NCBI Official Synonym Full Names    beta-site APP-cleaving enzyme 2
 NCBI Official Symbol    BACE2 [Similar Products]
 NCBI Official Synonym Symbols   
ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1
[Similar Products]
 NCBI Protein Information    beta-secretase 2
 UniProt Protein Name    Beta-secretase 2
 UniProt Synonym Protein Names   
Aspartic-like protease 56 kDa; Aspartyl protease 1; ASP1; Asp 1; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; DRAP; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase
 Protein Family    Beta-secretase
 UniProt Gene Name    BACE2 [Similar Products]
 UniProt Synonym Gene Names    AEPLC; ALP56; ASP21; ASP1; Asp 1; Beta-site APP cleaving enzyme 2; DRAP [Similar Products]
 UniProt Entry Name    BACE2_HUMAN
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 NCBI Summary for BACE2    This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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 UniProt Comments for BACE2    BACE2: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Belongs to the peptidase A1 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.23.45; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: Golgi apparatus

Molecular Function: aspartic-type endopeptidase activity; beta-amyloid binding

Biological Process: beta-amyloid metabolic process; membrane protein ectodomain proteolysis; negative regulation of amyloid precursor protein biosynthetic process; protein catabolic process
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 Research Articles on BACE2    1. RNA-seq evidence of biallelic expression of BACE2 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of BACE2 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BACE2 antibodyPathways associated with anti-BACE2 antibody
 Reference Product  PubMed Publications
 APP antibody  >113 publications with BACE2 and APP
 PSEN1 antibody  >11 publications with BACE2 and PSEN1
 FURIN antibody  >4 publications with BACE2 and FURIN
 RTN3 antibody  >2 publications with BACE2 and RTN3
 GGA2 antibody  >1 publications with BACE2 and GGA2
 GGA1 antibody  >1 publications with BACE2 and GGA1
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
Diseases associated with anti-BACE2 antibodyOrgans/Tissues associated with anti-BACE2 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >16 publications with BACE2 and Disease Models, Animal
 Inflammation Antibodies  >3 publications with BACE2 and Inflammation
 Pre-Eclampsia Antibodies  >2 publications with BACE2 and Pre-Eclampsia
 Necrosis Antibodies  >2 publications with BACE2 and Necrosis
 Learning Disorders Antibodies  >1 publications with BACE2 and Learning Disorders
 Edema Antibodies  >1 publications with BACE2 and Edema
 Neoplasms, Experimental Antibodies  >1 publications with BACE2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >99 publications with BACE2 and Brain
 Blood Antibodies  >12 publications with BACE2 and Blood
 Kidney Antibodies  >11 publications with BACE2 and Kidney
 Eye Antibodies  >6 publications with BACE2 and Eye
 Muscle Antibodies  >5 publications with BACE2 and Muscle
 Vascular Antibodies  >5 publications with BACE2 and Vascular
 Placenta Antibodies  >2 publications with BACE2 and Placenta
 Prostate Antibodies  >2 publications with BACE2 and Prostate
 Embryonic Tissue Antibodies  >1 publications with BACE2 and Embryonic Tissue
 Stomach Antibodies  >1 publications with BACE2 and Stomach
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