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anti-BAG2 antibody :: Rabbit anti-Human BAG family molecular chaperone regulator 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1492793
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BAG family molecular chaperone regulator 2 (BAG2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human BAG family molecular chaperone regulator 2 polyclonal Antibody(BAG2)

 Product Synonym Names    BAG-2; Bcl-2-associated athanogene 2; BAG2
 Product Gene Name   

anti-BAG2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603882
 3D Structure    ModBase 3D Structure for O95816
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human BAG family molecular chaperone regulator 2 protein (1-211aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-68948 / sc-68949
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-BAG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BAG2 antibody

   Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.
 Applications Tested/Suitable for anti-BAG2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-BAG2 antibody    Recommended dilution: WB:1:500-2000
IHC:1:20-1:200
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 Western Blot (WB) of anti-BAG2 antibody    All lanes: BAG family molecular chaperone regulator 2 antibody at 6ug/ml
Lane 1:Jurkat whole cell lysate
Lane 2:Hela whole cell lysate
Lane 3:HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 24,21 kDa
Observed band size: 24 kDa

anti-BAG2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-BAG2 antibody    Immunohistochemistry of paraffin-embedded human ovarian cancer using MBS1492793 at dilution 1:100
anti-BAG2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-BAG2 antibody    Immunohistochemistry of paraffin-embedded human kidney using MBS1492793 at dilution 1:100
anti-BAG2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for BAG2. It may not necessarily be applicable to this product.
 NCBI GI #    4757834
 NCBI GeneID    9532
 NCBI Accession #    NP_004273.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004282.3 [Other Products]
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 UniProt Primary Accession #    O95816 [Other Products]
 UniProt Secondary Accession #    Q08AS9; Q6FID0; B4DXE2 [Other Products]
 UniProt Related Accession #    O95816 [Other Products]
 Molecular Weight    20,189 Da
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 NCBI Official Full Name    BAG family molecular chaperone regulator 2
 NCBI Official Synonym Full Names    BCL2 associated athanogene 2
 NCBI Official Symbol    BAG2 [Similar Products]
 NCBI Official Synonym Symbols   
BAG-2; dJ417I1.2
[Similar Products]
 NCBI Protein Information    BAG family molecular chaperone regulator 2
 UniProt Protein Name    BAG family molecular chaperone regulator 2
 UniProt Synonym Protein Names   
Bcl-2-associated athanogene 2
 Protein Family    BAG family molecular chaperone regulator
 UniProt Gene Name    BAG2 [Similar Products]
 UniProt Synonym Gene Names    BAG-2 [Similar Products]
 UniProt Entry Name    BAG2_HUMAN
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 NCBI Summary for BAG2    BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BAG2    BAG2: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 6p12.1-p11.2

Cellular Component: cytosol

Molecular Function: chaperone binding; identical protein binding; protein binding

Biological Process: protein folding; protein metabolic process
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 Research Articles on BAG2    1. we measured the binding of human Hsp72 (HSPA1A) to BAG1, BAG2, BAG3, and the unrelated NEF Hsp105. These studies revealed a clear hierarchy of affinities: BAG3 > BAG1 > Hsp105 >> BAG2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BAG2 antibodyPathways associated with anti-BAG2 antibody
 Reference Product  PubMed Publications
 BAG1 antibody  >105 publications with BAG2 and BAG1
 BAG5 antibody  >3 publications with BAG2 and BAG5
 PINK1 antibody  >3 publications with BAG2 and PINK1
 BAG3 antibody  >2 publications with BAG2 and BAG3
 HSPA8 antibody  >2 publications with BAG2 and HSPA8
 STUB1 antibody  >1 publications with BAG2 and STUB1
 Products by Pathway  Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Regulation Of HSF1-mediated Heat Shock Response Pathway antibodies  Regulation Of HSF1-mediated Heat Shock Response Pathway Diagram
Diseases associated with anti-BAG2 antibodyOrgans/Tissues associated with anti-BAG2 antibody
 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >4 publications with BAG2 and Neoplasms, Experimental
 Brain Diseases Antibodies  >3 publications with BAG2 and Brain Diseases
 Liver Neoplasms Antibodies  >2 publications with BAG2 and Liver Neoplasms
 Liver Diseases Antibodies  >2 publications with BAG2 and Liver Diseases
 Fibrosis Antibodies  >2 publications with BAG2 and Fibrosis
 Disease Models, Animal Antibodies  >2 publications with BAG2 and Disease Models, Animal
 Liver Neoplasms, Experimental Antibodies  >2 publications with BAG2 and Liver Neoplasms, Experimental
 Necrosis Antibodies  >2 publications with BAG2 and Necrosis
 Nerve Degeneration Antibodies  >1 publications with BAG2 and Nerve Degeneration
 Prenatal Injuries Antibodies  >1 publications with BAG2 and Prenatal Injuries
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >126 publications with BAG2 and Muscle
 Brain Antibodies  >18 publications with BAG2 and Brain
 Embryonic Tissue Antibodies  >14 publications with BAG2 and Embryonic Tissue
 Eye Antibodies  >3 publications with BAG2 and Eye
 Liver Antibodies  >3 publications with BAG2 and Liver
 Skin Antibodies  >2 publications with BAG2 and Skin
 Thyroid Antibodies  >2 publications with BAG2 and Thyroid
 Bladder Antibodies  >1 publications with BAG2 and Bladder
 Kidney Antibodies  >1 publications with BAG2 and Kidney
 Stomach Antibodies  >1 publications with BAG2 and Stomach
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