NP_001693.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Related Accession #
Molecular Weight
173,501 Da
NCBI Official Full Name
brain-specific angiogenesis inhibitor 1
NCBI Official Synonym Full Names
brain-specific angiogenesis inhibitor 1
NCBI Official Synonym Symbols
NCBI Protein Information
brain-specific angiogenesis inhibitor 1
UniProt Protein Name
Brain-specific angiogenesis inhibitor 1
UniProt Entry Name
BAI1_HUMAN
NCBI Summary for BAI1
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
UniProt Comments for BAI1
BAI1: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Protein type: Receptor, GPCR; GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane; intercellular junction
Molecular Function: G-protein coupled receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; negative regulation of angiogenesis; axonogenesis; cell adhesion; signal transduction; peripheral nervous system development
Research Articles on BAI1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-BAI1 antibody
Pathways associated with anti-BAI1 antibody
Diseases associated with anti-BAI1 antibody
Organs/Tissues associated with anti-BAI1 antibody
|