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anti-BAIAP2 antibody :: Goat BAIAP2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420438
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BAIAP2, Polyclonal Antibody

 Also Known As   

Goat anti-BAIAP2 (isoform 1) Antibody

 Product Synonym Names    Goat Anti-BAIAP2 (isoform 3) Antibody; BAIAP2; BAI1-associated protein 2; BAP2; IRSP53; FLAF3; brain-specific angiogenesis inhibitor 1-associated protein 2; fas ligand-associated factor 3; insulin receptor substrate p53; insulin receptor substrate p53/p58; BAIAP2 antibody; BAI1-associated protein 2 antibody; BAP2 antibody; IRSP53 antibody; FLAF3 antibody; brain-specific angiogenesis inhibitor 1-associated protein 2 antibody; fas ligand-associated factor 3 antibody; insulin receptor substrate p53 antibody; insulin receptor substrate p53/p58 antibody; BAIAP2 (isoform 1)
 Product Gene Name   

anti-BAIAP2 antibody

[Similar Products]
 Antibody/Peptide Pairs    BAIAP2 peptide (MBS425462) is used for blocking the activity of BAIAP2 antibody (MBS420438)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    SGSGTLVSTV
 OMIM    605475
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-SGSGTLVSTV, from the C Terminus of the protein sequence according to NP_059344.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognise only human isoform 1 according to NP_059344.1.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-BAIAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-BAIAP2 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-BAIAP2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 60kDa band observed in Human Brain lysates (calculated MW of 57.4kDa according to NP_059344.1). Recommended for use at 1-3ug/ml.
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 Western Blot (WB) of anti-BAIAP2 antibody    Staining (1ug/ml) of Human Brain lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-BAIAP2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for BAIAP2. It may not necessarily be applicable to this product.
 NCBI GI #    9257197
 NCBI GeneID    10458
 NCBI Accession #    NP_059344.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_017450.2 [Other Products]
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 UniProt Secondary Accession #    O43858; Q53HB1; Q86WC1; Q8N5C0; Q96CR7; Q9UBR3; Q9UQ43 [Other Products]
 UniProt Related Accession #    Q9UQB8 [Other Products]
 Molecular Weight    57,430 Da
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 NCBI Official Full Name    brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 1
 NCBI Official Synonym Full Names    BAI1 associated protein 2
 NCBI Official Symbol    BAIAP2 [Similar Products]
 NCBI Official Synonym Symbols   
BAP2; FLAF3; IRSP53
[Similar Products]
 NCBI Protein Information    brain-specific angiogenesis inhibitor 1-associated protein 2
 UniProt Protein Name    Brain-specific angiogenesis inhibitor 1-associated protein 2
 UniProt Synonym Protein Names   
Fas ligand-associated factor 3; FLAF3; Insulin receptor substrate p53/p58; IRS-58; IRSp53/58; Insulin receptor substrate protein of 53 kDa; IRSp53; Insulin receptor substrate p53
 Protein Family    Brain-specific angiogenesis inhibitor 1-associated protein
 UniProt Gene Name    BAIAP2 [Similar Products]
 UniProt Synonym Gene Names    BAI-associated protein 2; BAI1-associated protein 2; Protein BAP2; FLAF3; IRS-58; IRSp53/58; IRSp53; Insulin receptor substrate p53 [Similar Products]
 UniProt Entry Name    BAIP2_HUMAN
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 NCBI Summary for BAIAP2    The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
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 UniProt Comments for BAIAP2    IRSp53: Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, BAI1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42. Interacts with TIAM1 and DIAPH1. Interacts (via SH3 domain) with E.coli effector protein EspF(U) (via PXXP motifs). Interacts with E.coli intimin receptor Tir. Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: actin cytoskeleton; cell-cell adherens junction; cytoplasm; cytosol; plasma membrane

Molecular Function: identical protein binding; protein binding; protein C-terminus binding

Biological Process: actin crosslink formation; actin filament bundle formation; axonogenesis; insulin receptor signaling pathway; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; regulation of cell shape; response to bacterium; vascular endothelial growth factor receptor signaling pathway
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 Research Articles on BAIAP2    1. determined the alpha-synuclein-binding domain of beta-III tubulin and demonstrated that a short fragment containing this domain can suppress alpha-synuclein accumulation in the primary cultured cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BAIAP2 antibodyPathways associated with anti-BAIAP2 antibody
 Reference Product  PubMed Publications
 CDC42 antibody  >26 publications with BAIAP2 and CDC42
 RAC1 antibody  >12 publications with BAIAP2 and RAC1
 EPS8 antibody  >10 publications with BAIAP2 and EPS8
 WASF2 antibody  >8 publications with BAIAP2 and WASF2
 ENAH antibody  >3 publications with BAIAP2 and ENAH
 ABI1 antibody  >3 publications with BAIAP2 and ABI1
 WASF1 antibody  >2 publications with BAIAP2 and WASF1
 WASL antibody  >1 publications with BAIAP2 and WASL
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 RAC1 Signaling Pathway antibodies  RAC1 Signaling Pathway Diagram
 RHO GTPase Effectors Pathway antibodies  RHO GTPase Effectors Pathway Diagram
 RHO GTPases Activate WASPs And WAVEs Pathway antibodies  RHO GTPases Activate WASPs And WAVEs Pathway Diagram
Diseases associated with anti-BAIAP2 antibodyOrgans/Tissues associated with anti-BAIAP2 antibody
 Disease Name  Pubmed Publications
 Learning Disorders Antibodies  >2 publications with BAIAP2 and Learning Disorders
 Memory Disorders Antibodies  >2 publications with BAIAP2 and Memory Disorders
 Proteinuria Antibodies  >1 publications with BAIAP2 and Proteinuria
 Cognition Disorders Antibodies  >1 publications with BAIAP2 and Cognition Disorders
 Cell Transformation, Neoplastic Antibodies  >1 publications with BAIAP2 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >1 publications with BAIAP2 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >1 publications with BAIAP2 and Kidney Diseases
 Disease Models, Animal Antibodies  >1 publications with BAIAP2 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >79 publications with BAIAP2 and Nerve
 Brain Antibodies  >28 publications with BAIAP2 and Brain
 Kidney Antibodies  >4 publications with BAIAP2 and Kidney
 Embryonic Tissue Antibodies  >1 publications with BAIAP2 and Embryonic Tissue
 Blood Antibodies  >1 publications with BAIAP2 and Blood
 Pituitary Gland Antibodies  >1 publications with BAIAP2 and Pituitary Gland
 Mammary Gland Antibodies  >1 publications with BAIAP2 and Mammary Gland
 Pancreas Antibodies  >1 publications with BAIAP2 and Pancreas
 Liver Antibodies  >1 publications with BAIAP2 and Liver
 Muscle Antibodies  >1 publications with BAIAP2 and Muscle
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