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anti-BAK1 antibody :: Rabbit BAK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2526104
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BAK1, Polyclonal Antibody

★Popular Item★
 Also Known As   

BAK1 Polyclonal Antibody

 Product Synonym Names    BAK; CDN1; BCL2L7; BAK-LIKE
 Product Gene Name   

anti-BAK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600516
 3D Structure    ModBase 3D Structure for Q16611
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1.1mg/mL (lot specific)
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 Immunogen    Recombinant protein of human BAK1
 Calculated Molecular Weight: 23kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-BAK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BAK1 antibody

   The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
 Product Categories/Family for anti-BAK1 antibody    Cell biology; Epigenetics
 Applications Tested/Suitable for anti-BAK1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-BAK1 antibody    WB: 1:500-1:2000
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 Western Blot (WB) of anti-BAK1 antibody    Western Blot analysis of Hela, A431, 293T and Jurkat cell using BAK1 Polyclonal Antibody at dilution of 1:550
anti-BAK1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for BAK1. It may not necessarily be applicable to this product.
 NCBI GI #    48146955
 NCBI GeneID    578
 NCBI Accession #    CAG33700.1 [Other Products]
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 UniProt Primary Accession #    Q16611 [Other Products]
 UniProt Secondary Accession #    Q6I9T6; Q92533; C0H5Y7 [Other Products]
 UniProt Related Accession #    Q16611 [Other Products]
 Molecular Weight    16,872 Da
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 NCBI Official Full Name    BAK1
 NCBI Official Synonym Full Names    BCL2-antagonist/killer 1
 NCBI Official Symbol    BAK1 [Similar Products]
 NCBI Official Synonym Symbols   
BAK; CDN1; BCL2L7; BAK-LIKE
[Similar Products]
 NCBI Protein Information    bcl-2 homologous antagonist/killer; BCL2-like 7 protein; apoptosis regulator BAK; bcl-2-like protein 7; bcl2-L-7; pro-apoptotic protein BAK
 UniProt Protein Name    Bcl-2 homologous antagonist/killer
 UniProt Synonym Protein Names   
Apoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7
 Protein Family    Bcl-2 homologous antagonist/killer
 UniProt Gene Name    BAK1 [Similar Products]
 UniProt Synonym Gene Names    BAK; BCL2L7; CDN1; Bcl2-L-7 [Similar Products]
 UniProt Entry Name    BAK_HUMAN
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 NCBI Summary for BAK1    The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BAK1    BAK1: In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. Interacts with BCL2A1. Homodimer. Formation of the homodimer is zinc-dependent. Forms heterodimers with BCL2, E1B 19k protein, and BCL2L1 isoform Bcl-X(L). Interacts with myxoma virus protein M11L. Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle. Belongs to the Bcl-2 family.

Protein type: Mitochondrial; Apoptosis; Endoplasmic reticulum; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: pore complex; mitochondrial outer membrane; mitochondrion; endoplasmic reticulum; cytosol; integral to mitochondrial outer membrane

Molecular Function: identical protein binding; BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity; heat shock protein binding; chaperone binding; metal ion binding

Biological Process: response to fungus; regulation of protein heterodimerization activity; positive regulation of proteolysis; apoptosis; regulation of cell cycle; positive regulation of apoptosis; myeloid cell homeostasis; negative regulation of peptidyl-serine phosphorylation; B cell apoptosis; response to organic cyclic substance; negative regulation of cell proliferation; B cell homeostasis; regulation of mitochondrial membrane potential; response to gamma radiation; establishment and/or maintenance of transmembrane electrochemical gradient; B cell negative selection; aging; response to drug; organ regeneration; release of cytochrome c from mitochondria; mitochondrial fusion; response to mycotoxin; regulation of protein homodimerization activity; vagina development; limb morphogenesis; endocrine pancreas development; response to UV-C; cell proliferation; endoplasmic reticulum calcium ion homeostasis; unfolded protein response, activation of signaling protein activity; response to ethanol; DNA damage response, signal transduction resulting in induction of apoptosis; response to hydrogen peroxide; reduction of endoplasmic reticulum calcium ion concentration; blood vessel remodeling; caspase activation via cytochrome c; regulation of mitochondrial membrane permeability; brain development; post-embryonic camera-type eye morphogenesis
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 Research Articles on BAK1    1. This progress has resolved longstanding controversies, but has also challenged established theories in the apoptosis field, it focus on the recent progress made in characterizing the proapoptotic Bax and Bak.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BAK1 antibodyPathways associated with anti-BAK1 antibody
 Reference Product  PubMed Publications
 BAX antibody  >598 publications with BAK1 and BAX
 BCL2L1 antibody  >244 publications with BAK1 and BCL2L1
 BID antibody  >117 publications with BAK1 and BID
 BCL2 antibody  >74 publications with BAK1 and BCL2
 MCL1 antibody  >37 publications with BAK1 and MCL1
 PMAIP1 antibody  >29 publications with BAK1 and PMAIP1
 TP53 antibody  >24 publications with BAK1 and TP53
 VDAC2 antibody  >9 publications with BAK1 and VDAC2
 VDAC1 antibody  >8 publications with BAK1 and VDAC1
 BCL2L11 antibody  >4 publications with BAK1 and BCL2L11
 Products by Pathway  Pathway Diagram
 Activation And Oligomerization Of BAK Protein Pathway antibodies  Activation And Oligomerization Of BAK Protein Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Intrinsic Pathway For Apoptosis antibodies  Intrinsic Pathway For Apoptosis Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
Diseases associated with anti-BAK1 antibodyOrgans/Tissues associated with anti-BAK1 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >105 publications with BAK1 and Necrosis
 Gastrointestinal Diseases Antibodies  >57 publications with BAK1 and Gastrointestinal Diseases
 Breast Neoplasms Antibodies  >47 publications with BAK1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >36 publications with BAK1 and Nervous System Diseases
 Lung Neoplasms Antibodies  >31 publications with BAK1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >26 publications with BAK1 and Neoplasms, Experimental
 Carcinoma, Squamous Cell Antibodies  >25 publications with BAK1 and Carcinoma, Squamous Cell
 Brain Diseases Antibodies  >25 publications with BAK1 and Brain Diseases
 Colonic Neoplasms Antibodies  >25 publications with BAK1 and Colonic Neoplasms
 Inflammation Antibodies  >22 publications with BAK1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >136 publications with BAK1 and Blood
 Liver Antibodies  >51 publications with BAK1 and Liver
 Lung Antibodies  >46 publications with BAK1 and Lung
 Brain Antibodies  >45 publications with BAK1 and Brain
 Kidney Antibodies  >30 publications with BAK1 and Kidney
 Intestine Antibodies  >30 publications with BAK1 and Intestine
 Prostate Antibodies  >29 publications with BAK1 and Prostate
 Bone Antibodies  >28 publications with BAK1 and Bone
 Vascular Antibodies  >25 publications with BAK1 and Vascular
 Skin Antibodies  >22 publications with BAK1 and Skin
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