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anti-SIL1 antibody :: Goat BAP/SIL1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421280
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BAP/SIL1, Polyclonal Antibody

 Also Known As   

Goat anti-BAP/SIL1 Antibody

 Product Synonym Names    SIL1; BAP; endoplasmic reticulum chaperone SIL1, homolog of yeast; BiP-associated protein; SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae); MSS; ULG5; SIL1 protein; SIL1 antibody; BAP antibody; endoplasmic reticulum chaperone SIL1; homolog of yeast antibody; BiP-associated protein antibody; SIL1 homolog; endoplasmic reticulum chaperone (S. cerevisiae) antibody; MSS antibody; ULG5 antibody; SIL1 protein antibody; BAP / SIL1
 Product Gene Name   

anti-SIL1 antibody

[Similar Products]
 Product Synonym Gene Name    BAP [Similar Products]
 Antibody/Peptide Pairs    BAP / SIL1 peptide (MBS425728) is used for blocking the activity of BAP/SIL1 antibody (MBS421280)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    ELLGSVNSLL KELR
 OMIM    248800
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-ELLGSVNSLLKELR, from the C Terminus of the protein sequence according to NP_071909.1; NP_001032722.1.
 Epitope    C Terminus
 Note    Variants (NP_071909.1; NP_001032722.1) encode the same isoform.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SIL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SIL1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-SIL1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 55-60 kDa band observed in Human Liver and Kidney extracts (predicted MW of 53kDa according to NP_071909.1). Recommended for use at 1-2ug/ml.
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 Western Blot (WB) of anti-SIL1 antibody    Staining (1ug/ml) of Human Kidney lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-SIL1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SIL1. It may not necessarily be applicable to this product.
 NCBI GI #    11968009
 NCBI GeneID    64374
 NCBI Accession #    NP_071909.1 [Other Products]
 NCBI Related Accession #    NP_001032722.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_022464.4 [Other Products]
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 UniProt Secondary Accession #    Q8N2L3; D3DQC2 [Other Products]
 UniProt Related Accession #    Q9H173 [Other Products]
 Molecular Weight    52,085 Da
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 NCBI Official Full Name    nucleotide exchange factor SIL1
 NCBI Official Synonym Full Names    SIL1 nucleotide exchange factor
 NCBI Official Symbol    SIL1 [Similar Products]
 NCBI Official Synonym Symbols   
BAP; MSS; ULG5
[Similar Products]
 NCBI Protein Information    nucleotide exchange factor SIL1
 UniProt Protein Name    Nucleotide exchange factor SIL1
 UniProt Synonym Protein Names   
BiP-associated protein; BAP
 Protein Family    Silaffin
 UniProt Gene Name    SIL1 [Similar Products]
 UniProt Synonym Gene Names    BAP [Similar Products]
 UniProt Entry Name    SIL1_HUMAN
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 NCBI Summary for SIL1    This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SIL1    SIL1: Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. Defects in SIL1 are a cause of Marinesco-Sjoegren syndrome (MSS). MSS is an autosomal recessive multisystem disorder which is characterized by cerebellar ataxia due to cerebellar atrophy, with Purkinje and granule cell loss and myopathy featuring marked muscle replacement with fat and connective tissue. Other cardinal features include bilateral cataracts, hypergonadotrophic hypogonadism and mild to severe mental retardation. Skeletal abnormalities, short stature, dysarthria, strabismus and nystagmus are also frequent findings. Mutational inactivation of this protein may result in ER stress- induced cell death signaling or malfunctioning chaperone machineries that mishandle client proteins which are critical for the organs targeted in MSS. Belongs to the SIL1 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; extracellular space

Molecular Function: protein binding; unfolded protein binding

Biological Process: intracellular protein transport; protein folding

Disease: Marinesco-sjogren Syndrome
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 Research Articles on SIL1    1. This study demonistrated that SIL1 mutation in patient with ataxia telangiectasia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SIL1 antibodyDiseases associated with anti-SIL1 antibody
 Products by Pathway  Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Disease Name  Pubmed Publications
 Spinocerebellar Degenerations Antibodies  >27 publications with SIL1 and Spinocerebellar Degenerations
 Atrophy Antibodies  >9 publications with SIL1 and Atrophy
 Liver Diseases Antibodies  >2 publications with SIL1 and Liver Diseases
 Inflammation Antibodies  >2 publications with SIL1 and Inflammation
 Necrosis Antibodies  >2 publications with SIL1 and Necrosis
 Immune System Diseases Antibodies  >2 publications with SIL1 and Immune System Diseases
 Glucose Intolerance Antibodies  >1 publications with SIL1 and Glucose Intolerance
 Cardiovascular Diseases Antibodies  >1 publications with SIL1 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >1 publications with SIL1 and Liver Neoplasms
 Vascular Diseases Antibodies  >1 publications with SIL1 and Vascular Diseases
Organs/Tissues associated with anti-SIL1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with SIL1 and Brain
 Blood Antibodies  >11 publications with SIL1 and Blood
 Muscle Antibodies  >10 publications with SIL1 and Muscle
 Bone Antibodies  >4 publications with SIL1 and Bone
 Liver Antibodies  >3 publications with SIL1 and Liver
 Pancreas Antibodies  >2 publications with SIL1 and Pancreas
 Vascular Antibodies  >1 publications with SIL1 and Vascular
 Heart Antibodies  >1 publications with SIL1 and Heart
 Connective Tissue Antibodies  >1 publications with SIL1 and Connective Tissue
 Kidney Antibodies  >1 publications with SIL1 and Kidney
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