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anti-BARD1 antibody :: Rabbit anti-Human BARD1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9600308
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BARD1, Polyclonal Antibody

★Popular Item★
 Also Known As   

BARD1 Antibody

 Product Synonym Names    Disrupted meiotic cDNA 1 homolog; Disrupted meiotic cDNA 1, yeast, homolog of; dJ199H16.1; DMC 1; DMC1; DMC1 dosage suppressor of mck1 homolog; DMC1 dosage suppressor of mck1 homolog meiosis specific homologous recombination (yeast); DMC1 homologue; DMC1_HUMAN; DMC1H; DNA meiotic recombinase 1; HsLim15; LIM15; Meiotic recombination protein DMC1/LIM15 homolog; MGC150472; MGC150473
 Product Gene Name   

anti-BARD1 antibody

[Similar Products]
 Product Synonym Gene Name    DMC1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q14565
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    BARD1 antibody detects endogenous levels of total BARD1
 Purity/Purification    The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
 Form/Format    Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    A synthesized peptide derived from human BARD1
 Subcellular Location    Nucleus. Chromosome.
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Stable for 12 months from date of receipt.
 Other Notes    Small volumes of anti-BARD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BARD1 antibody

   Description: BARD1 the BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. Colocalizes with BRCA1 into discrete subnuclear foci during S phase. Can translocate to the cytoplasm.
Function: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
Subunit Structure: Interacts with the MND1-PSMC3IP heterodimer (By similarity). Double stacked ring-shaped homooctamer. Interacts with BRCA2.
Similarity: Belongs to the RecA family. DMC1 subfamily.
 Applications Tested/Suitable for anti-BARD1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-BARD1 antibody    WB: 1:500-1:3000
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 Western Blot (WB) of anti-BARD1 antibody    Western blot analysis on HeLa cell lysate using BARD1 Antibody, The lane on the left is treated with the antigen-specific peptide.
anti-BARD1 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-BARD1 antibody    Western blot analysis of extracts from 293, using BARD1 Antibody.
anti-BARD1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for BARD1. It may not necessarily be applicable to this product.
 NCBI GI #    506324319
 NCBI GeneID    11144
 NCBI Accession #    NP_001265137.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278208.1 [Other Products]
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 UniProt Primary Accession #    Q14565 [Other Products]
 UniProt Secondary Accession #    Q08AI1; Q99498; Q9UH11; A8K9A2; B4DMW6 [Other Products]
 UniProt Related Accession #    Q14565 [Other Products]
 Molecular Weight    Observed: 86 kDa
Predicted: 38 kDa
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 NCBI Official Full Name    meiotic recombination protein DMC1/LIM15 homolog isoform 2
 NCBI Official Synonym Full Names    DNA meiotic recombinase 1
 NCBI Official Symbol    DMC1 [Similar Products]
 NCBI Official Synonym Symbols   
DMC1H; LIM15; dJ199H16.1
[Similar Products]
 NCBI Protein Information    meiotic recombination protein DMC1/LIM15 homolog
 UniProt Protein Name    Meiotic recombination protein DMC1/LIM15 homolog
 Protein Family    BRCA1-associated RING domain protein
 UniProt Gene Name    DMC1 [Similar Products]
 UniProt Synonym Gene Names    DMC1H; LIM15 [Similar Products]
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 NCBI Summary for BARD1    This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
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 UniProt Comments for BARD1    May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
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 Research Articles on BARD1    1. Data indicate that ahomologous pairing by DMC1 protein or RAD51 recombinase in chromatin containing nucleosome-depleted double-stranded DNA (dsDNA) regions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BARD1 antibodyPathways associated with anti-BARD1 antibody
 Reference Product  PubMed Publications
 RAD51 antibody  >185 publications with BARD1 and RAD51
 RAD54B antibody  >5 publications with BARD1 and RAD54B
 RPA1 antibody  >1 publications with BARD1 and RPA1
 Products by Pathway  Pathway Diagram
 Meiosis Pathway antibodies  Meiosis Pathway Diagram
 Meiotic Recombination Pathway antibodies  Meiotic Recombination Pathway Diagram
 Ovarian Infertility Genes Pathway antibodies  Ovarian Infertility Genes Pathway Diagram
Diseases associated with anti-BARD1 antibodyOrgans/Tissues associated with anti-BARD1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with BARD1 and Neoplasms
 Breast Neoplasms Antibodies  >4 publications with BARD1 and Breast Neoplasms
 Kidney Diseases Antibodies  >4 publications with BARD1 and Kidney Diseases
 Mental Disorders Antibodies  >2 publications with BARD1 and Mental Disorders
 Testicular Diseases Antibodies  >2 publications with BARD1 and Testicular Diseases
 Lung Neoplasms Antibodies  >1 publications with BARD1 and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >1 publications with BARD1 and Ovarian Neoplasms
 Carcinoma, Squamous Cell Antibodies  >1 publications with BARD1 and Carcinoma, Squamous Cell
 Lung Diseases Antibodies  >1 publications with BARD1 and Lung Diseases
 Uterine Cervical Neoplasms Antibodies  >1 publications with BARD1 and Uterine Cervical Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >35 publications with BARD1 and Testis
 Ovary Antibodies  >17 publications with BARD1 and Ovary
 Blood Antibodies  >7 publications with BARD1 and Blood
 Thymus Antibodies  >2 publications with BARD1 and Thymus
 Embryonic Tissue Antibodies  >2 publications with BARD1 and Embryonic Tissue
 Heart Antibodies  >1 publications with BARD1 and Heart
 Brain Antibodies  >1 publications with BARD1 and Brain
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