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anti-BAX antibody :: Rabbit BAX Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS820141
Immunohistochemistry (IHC)
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BAX, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-BAX Antibody

 Product Synonym Names    BCL2L4; Apoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4
 Product Gene Name   

anti-BAX antibody

[Similar Products]
 Antibody/Peptide Pairs    BAX peptide (MBS822360) is used for blocking the activity of BAX antibody (MBS820141)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600040
 3D Structure    ModBase 3D Structure for Q07812
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Bovine, Dog, Pig
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 Specificity    Recognizes endogenous levels of BAX protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human BAX. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-BAX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-BAX antibody

   Rabbit polyclonal antibody to BAX
 Applications Tested/Suitable for anti-BAX antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-BAX antibody    E (1/5000 - 1/10000), WB (1/500 - 1/1000), IH (1/100 - 1/200)
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 Western Blot (WB) of anti-BAX antibody    anti-BAX antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-BAX antibody    Immunohistochemical analysis of BAX staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-BAX antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for BAX. It may not necessarily be applicable to this product.
 NCBI GI #    612149787
 NCBI GeneID    581
 NCBI Accession #    NP_001278357.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001291428.1 [Other Products]
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 UniProt Primary Accession #    Q07812 [Other Products]
 UniProt Secondary Accession #    P55269; Q07814; Q07815; Q8WZ49; Q9NR76; Q9NYG7; Q9UCZ6; Q9UCZ7; Q9UQD6; A8K4W1 [Other Products]
 UniProt Related Accession #    Q07812 [Other Products]
 Molecular Weight    19,718 Da
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 NCBI Official Full Name    apoptosis regulator BAX isoform 1
 NCBI Official Synonym Full Names    BCL2-associated X protein
 NCBI Official Symbol    BAX [Similar Products]
 NCBI Official Synonym Symbols   
BCL2L4
[Similar Products]
 NCBI Protein Information    apoptosis regulator BAX; bcl2-L-4; Baxdelta2G9; Baxdelta2omega; Baxdelta2G9omega; bcl-2-like protein 4; BCL2-associated X protein omega
 UniProt Protein Name    Apoptosis regulator BAX
 UniProt Synonym Protein Names   
Bcl-2-like protein 4; Bcl2-L-4
 Protein Family    Bax inhibitor
 UniProt Gene Name    BAX [Similar Products]
 UniProt Synonym Gene Names    BCL2L4; Bcl2-L-4 [Similar Products]
 UniProt Entry Name    BAX_HUMAN
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 NCBI Summary for BAX    The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BAX    BAX: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. Homodimer. Forms higher oligomers under stress conditions. Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells. Interacts with FAIM2/LFG2. Interacts with human cytomegalovirus/HHV-5 protein vMIA/UL37. Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro- myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T- cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines. Belongs to the Bcl-2 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Tumor suppressor; Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: mitochondrial permeability transition pore complex; pore complex; endoplasmic reticulum membrane; mitochondrial outer membrane; membrane; mitochondrion; endoplasmic reticulum; nuclear envelope; cytosol; nucleus

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; channel activity; BH3 domain binding; lipid binding

Biological Process: hypothalamus development; viral reproduction; regulation of cell cycle; positive regulation of apoptosis; response to toxin; myeloid cell homeostasis; germ cell programmed cell death; B cell apoptosis; germ cell development; regulation of mammary gland epithelial cell proliferation; spermatid differentiation; regulation of mitochondrial membrane potential; development of secondary sexual characteristics; protein insertion into mitochondrial membrane during induction of apoptosis; establishment and/or maintenance of transmembrane electrochemical gradient; negative regulation of neuron apoptosis; kidney development; negative regulation of protein binding; release of cytochrome c from mitochondria; positive regulation of B cell apoptosis; regulation of protein homodimerization activity; vagina development; protein oligomerization; fertilization; unfolded protein response, activation of signaling protein activity; DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; retina development in camera-type eye; negative regulation of fibroblast proliferation; reduction of endoplasmic reticulum calcium ion concentration; glycosphingolipid metabolic process; cerebral cortex development; mitochondrial fragmentation during apoptosis; regulation of nitrogen utilization; post-embryonic camera-type eye morphogenesis; regulation of protein heterodimerization activity; positive regulation of pigmentation; T cell homeostatic proliferation; apoptosis; positive regulation of apoptosis involved in mammary gland involution; neuron migration; negative regulation of peptidyl-serine phosphorylation; release of matrix enzymes from mitochondria; response to salt stress; positive regulation of protein oligomerization; apoptotic mitochondrial changes; B cell homeostatic proliferation; ovarian follicle development; B cell homeostasis; positive regulation of neuron apoptosis; response to gamma radiation; response to axon injury; B cell negative selection; protein homooligomerization; caspase activation; mitochondrial fusion; transformed cell apoptosis; Sertoli cell proliferation; odontogenesis of dentine-containing teeth; endoplasmic reticulum calcium ion homeostasis; neuron apoptosis; homeostasis of number of cells within a tissue; retinal cell programmed cell death; blood vessel remodeling; positive regulation of release of sequestered calcium ion into cytosol; caspase activation via cytochrome c
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 Research Articles on BAX    1. Bax protein is probably very significant in the cancerogenesis mechanism in the large intestine.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-BAX antibodyDiseases associated with anti-BAX antibody
 Products by Pathway  Pathway Diagram
 Activation, Translocation And Oligomerization Of BAX Pathway antibodies  Activation, Translocation And Oligomerization Of BAX Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1976 publications with BAX and Necrosis
 Heart Diseases Antibodies  >1824 publications with BAX and Heart Diseases
 Nervous System Diseases Antibodies  >1819 publications with BAX and Nervous System Diseases
 Ischemia Antibodies  >1500 publications with BAX and Ischemia
 Brain Diseases Antibodies  >1361 publications with BAX and Brain Diseases
 Inflammation Antibodies  >989 publications with BAX and Inflammation
 Breast Neoplasms Antibodies  >937 publications with BAX and Breast Neoplasms
 Liver Diseases Antibodies  >933 publications with BAX and Liver Diseases
 Intestinal Neoplasms Antibodies  >814 publications with BAX and Intestinal Neoplasms
 Neoplasms, Experimental Antibodies  >749 publications with BAX and Neoplasms, Experimental
Organs/Tissues associated with anti-BAX antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3097 publications with BAX and Blood
 Brain Antibodies  >2386 publications with BAX and Brain
 Liver Antibodies  >1696 publications with BAX and Liver
 Lung Antibodies  >1297 publications with BAX and Lung
 Bone Antibodies  >772 publications with BAX and Bone
 Nerve Antibodies  >723 publications with BAX and Nerve
 Prostate Antibodies  >701 publications with BAX and Prostate
 Skin Antibodies  >510 publications with BAX and Skin
 Stomach Antibodies  >487 publications with BAX and Stomach
 Eye Antibodies  >391 publications with BAX and Eye
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