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anti-CXCL13 antibody :: Rabbit anti-Human BCA1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175222
Western Blot (WB)
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 Product Name   

BCA1 (CXCL13), Polyclonal Antibody

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 Also Known As   

Anti-BCA1 antibody

 Product Synonym Names    C-X-C motif chemokine 13; chemokine(C-X-C motif) ligand 13; ANGIE antibody; ANGIE2 antibody; B cell attracting chemokine 1 antibody; B cell-attracting chemokine 1 antibody; B lymphocyte chemoattractant antibody; B-cell chemoattractant antibody; B-cell-attracting chemokine 1 antibody; BCA-1 antibody; BLC antibody; BLR1L antibody; C-X-C motif chemokine 13 antibody; Chemokine(C-X-C motif) ligand 13 antibody; Chemokine(C-X-C motif) ligand 13(B-cell chemoattractant) antibody; Chemokine, CXC motif, ligand 13 antibody; CXC chemokine BLC antibody; CXCL13 antibody; CXL13_HUMAN antibody; SCYB13 antibody; Small inducible cytokine B subfamily(Cys-X-Cys motif), member 13(B-cell chemoattractant) antibody; Small inducible cytokine B13 antibody; Small inducible cytokine subfamily B, member 13 antibody; Small-inducible cytokine B13 antibody
 Product Gene Name   

anti-CXCL13 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605149
 3D Structure    ModBase 3D Structure for O43927
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human BCA1 (78-94aa DPQAEWIQRMMEVLRKR).
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CXCL13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CXCL13 antibody

   Description: Rabbit IgG polyclonal antibody for C-X-C motif chemokine 13(CXCL13) detection. Tested with WB, IHC-P in Human.
Background: C-X-C motif chemokine 13(CXCL13) also known as B lymphocyte chemoattractant(BLC) is a protein that in humans is encoded by the CXCL13 gene. CXCL3 is a small cytokine belonging to the CXC chemokine family. Its gene is mapped to human chromosome 4 in a cluster of other CXC chemokines. This protein has contained 109 amino acids. It is expressed highly in the liver, spleen, lymph nodes and gut of humans. The protein induces chemotaxis of BLR1-expressing B cells.
 Applications Tested/Suitable for anti-CXCL13 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

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 Western Blot (WB) of anti-CXCL13 antibody    Anti-BCA1 antibody, MBS175222, Western blotting
Lane 1: Recombinant Human CXCL13 Protein 10ng
Lane 2: Recombinant Human CXCL13 Protein 5ng
Lane 3: Recombinant Human CXCL13 Protein 2.5ng
anti-CXCL13 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CXCL13. It may not necessarily be applicable to this product.
 NCBI GI #    7673945
 NCBI GeneID    10563
 NCBI Accession #    O43927.1 [Other Products]
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 UniProt Primary Accession #    O43927 [Other Products]
 UniProt Related Accession #    O43927 [Other Products]
 Molecular Weight    12,664 Da
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 NCBI Official Full Name    C-X-C motif chemokine 13
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 13
 NCBI Official Symbol    CXCL13 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    C-X-C motif chemokine 13; CXC chemokine BLC; B-cell chemoattractant; B-lymphocyte chemoattractant; b lymphocyte chemoattractant; small-inducible cytokine B13; B-cell-attracting chemokine 1; b cell-attracting chemokine 1; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant)
 UniProt Protein Name    C-X-C motif chemokine 13
 UniProt Synonym Protein Names   
Angie; B cell-attracting chemokine 1; BCA-1; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13
 Protein Family    C-X-C motif chemokine
 UniProt Gene Name    CXCL13 [Similar Products]
 UniProt Synonym Gene Names    BCA1; BLC; SCYB13; BCA-1 [Similar Products]
 UniProt Entry Name    CXL13_HUMAN
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 NCBI Summary for CXCL13    B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]
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 UniProt Comments for CXCL13    CXCL13: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; fibroblast growth factor binding; CXCR3 chemokine receptor binding; chemokine activity; protein heterodimerization activity; CXCR5 chemokine receptor binding; CCR10 chemokine receptor binding; receptor agonist activity

Biological Process: chronic inflammatory response; lymphocyte chemotaxis across high endothelial venule; response to lipopolysaccharide; regulation of angiogenesis; positive regulation of integrin activation; positive regulation of cell-cell adhesion mediated by integrin; lymph node development; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; cell-cell signaling; regulation of humoral immune response; defense response to bacterium; germinal center formation; immune response; inflammatory response
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 Research Articles on CXCL13    1. CXCL13 displays antimicrobial activity against E. coli and S. aureus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CXCL13 antibodyPathways associated with anti-CXCL13 antibody
 Reference Product  PubMed Publications
 CXCR5 antibody  >184 publications with CXCL13 and CXCR5
 CCL21 antibody  >121 publications with CXCL13 and CCL21
 CCL19 antibody  >97 publications with CXCL13 and CCL19
 CCR7 antibody  >50 publications with CXCL13 and CCR7
 CXCL9 antibody  >28 publications with CXCL13 and CXCL9
 CXCR3 antibody  >27 publications with CXCL13 and CXCR3
 CCL20 antibody  >23 publications with CXCL13 and CCL20
 CXCL11 antibody  >14 publications with CXCL13 and CXCL11
 CCL25 antibody  >12 publications with CXCL13 and CCL25
 CXCR1 antibody  >8 publications with CXCL13 and CXCR1
 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with anti-CXCL13 antibodyOrgans/Tissues associated with anti-CXCL13 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >148 publications with CXCL13 and Inflammation
 Necrosis Antibodies  >57 publications with CXCL13 and Necrosis
 Disease Models, Animal Antibodies  >47 publications with CXCL13 and Disease Models, Animal
 Carcinoma Antibodies  >30 publications with CXCL13 and Carcinoma
 Lung Diseases Antibodies  >29 publications with CXCL13 and Lung Diseases
 Neoplasms, Experimental Antibodies  >18 publications with CXCL13 and Neoplasms, Experimental
 Hyperplasia Antibodies  >18 publications with CXCL13 and Hyperplasia
 Adenocarcinoma Antibodies  >12 publications with CXCL13 and Adenocarcinoma
 Liver Diseases Antibodies  >12 publications with CXCL13 and Liver Diseases
 Skin Neoplasms Antibodies  >10 publications with CXCL13 and Skin Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >178 publications with CXCL13 and Lymph Node
 Spleen Antibodies  >78 publications with CXCL13 and Spleen
 Bone Antibodies  >67 publications with CXCL13 and Bone
 Vascular Antibodies  >65 publications with CXCL13 and Vascular
 Lung Antibodies  >43 publications with CXCL13 and Lung
 Kidney Antibodies  >23 publications with CXCL13 and Kidney
 Pharynx Antibodies  >20 publications with CXCL13 and Pharynx
 Intestine Antibodies  >19 publications with CXCL13 and Intestine
 Muscle Antibodies  >19 publications with CXCL13 and Muscle
 Prostate Antibodies  >18 publications with CXCL13 and Prostate
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