Q96HL2
[Other Products]
UniProt Related Accession #
NCBI Official Full Name
BCHE protein
NCBI Official Synonym Full Names
butyrylcholinesterase
NCBI Official Synonym Symbols
NCBI Protein Information
cholinesterase; cholinesterase 1; OTTHUMP00000212636; choline esterase II; pseudocholinesterase; butyrylcholine esterase; acylcholine acylhydrolase
UniProt Protein Name
BCHE protein
UniProt Entry Name
Q96HL2_HUMAN
NCBI Summary for BCHE
Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq]
UniProt Comments for BCHE
BCHE: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency). BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. Belongs to the type-B carboxylesterase/lipase family.
Protein type: Secreted; Nuclear envelope; Hydrolase; EC 3.1.1.8; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q26.1-q26.2
Cellular Component: membrane; nuclear envelope lumen; endoplasmic reticulum lumen; extracellular region
Molecular Function: choline binding; identical protein binding; enzyme binding; cholinesterase activity; beta-amyloid binding; acetylcholinesterase activity; catalytic activity
Biological Process: response to drug; response to alkaloid; negative regulation of cell proliferation; cellular protein metabolic process; choline metabolic process; cocaine metabolic process; response to folic acid; response to glucocorticoid stimulus; neuroblast differentiation; learning; negative regulation of synaptic transmission
Research Articles on BCHE
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-BCHE antibody
Pathways associated with anti-BCHE antibody
Diseases associated with anti-BCHE antibody
Organs/Tissues associated with anti-BCHE antibody
|