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anti-BCL2L1 antibody :: Rabbit anti-Human BCL2L1 / BCL-XL Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240481
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BCL2L1 / BCL-XL, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human BCL2L1 / BCL-XL

 Product Synonym Names    Anti-BCL2L1 / BCL-XL Antibody (C-Terminus) IHC-plus; BCL2L1; Apoptosis regulator Bcl-X; Bcl-xL; BCL-XL/S; BCLXS; Bcl-2-like protein 1; BCL2-like 1; BCL2L; Bcl-X; Bcl-xS; BCLXL; PPP1R52; Bcl2-L-1; BCLX; Human BCL2L1; BCL-XL
 Product Gene Name   

anti-BCL2L1 antibody

[Similar Products]
 Product Synonym Gene Name    BCL-XL [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600039
 3D Structure    ModBase 3D Structure for Q07817
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    peptide corresponding to 14 amino acids near the carboxy-terminus of human Bcl-xL
 Purity/Purification    Ion exchange Chromatography
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human BCL2L1 / Bcl-xL.
 Immunogen Type    Synthetic peptide
 Immunogen    BCL2L1 / BCL-XL antibody was raised against synthetic peptide from human BCL2L1 / Bcl-xL.
 Antigen Modification    C-Terminus
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-BCL2L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BCL2L1 antibody

   Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death.
 Product Categories/Family for anti-BCL2L1 antibody    Family: Apoptosis
 Applications Tested/Suitable for anti-BCL2L1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-BCL2L1 antibody    IHC-P (2.5 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-BCL2L1 antibody    Anti-BCL2L1 / Bcl-x antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
anti-BCL2L1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-BCL2L1 antibody    Anti-BCL2L1 / Bcl-x antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-BCL2L1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-BCL2L1 antibody    Western blot of Bcl-xL in A549 cell lysates with Bcl-xL antibody at (A) 1 and (B) 2 ug/ml.
anti-BCL2L1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for BCL2L1. It may not necessarily be applicable to this product.
 NCBI GI #    4502381
 NCBI GeneID    598
 NCBI Accession #    NP_001182.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001191.2 [Other Products]
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 UniProt Primary Accession #    Q07817 [Other Products]
 UniProt Secondary Accession #    Q5CZ89; Q5TE65; Q92976; E1P5L6 [Other Products]
 UniProt Related Accession #    Q07817 [Other Products]
 Molecular Weight    25,290 Da
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 NCBI Official Full Name    bcl-2-like protein 1 isoform 2
 NCBI Official Synonym Full Names    BCL2-like 1
 NCBI Official Symbol    BCL2L1 [Similar Products]
 NCBI Official Synonym Symbols   
BCLX; BCL2L; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; PPP1R52; BCL-XL/S
[Similar Products]
 NCBI Protein Information    bcl-2-like protein 1; apoptosis regulator Bcl-X; protein phosphatase 1, regulatory subunit 52
 UniProt Protein Name    Bcl-2-like protein 1
 UniProt Synonym Protein Names   
Apoptosis regulator Bcl-X
 Protein Family    Bcl-2-like protein
 UniProt Gene Name    BCL2L1 [Similar Products]
 UniProt Synonym Gene Names    BCL2L; BCLX; Bcl2-L-1 [Similar Products]
 UniProt Entry Name    B2CL1_HUMAN
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 NCBI Summary for BCL2L1    The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BCL2L1    Bcl-xL: an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported.

Protein type: Apoptosis; Membrane protein, integral; Autophagy; Mitochondrial

Chromosomal Location of Human Ortholog: 20q11.21

Cellular Component: centrosome; mitochondrial outer membrane; nuclear membrane; synaptic vesicle membrane; mitochondrion; mitochondrial matrix; mitochondrial inner membrane; cytoplasm; integral to membrane; nucleolus; nucleus; cell junction; cytosol

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; BH3 domain binding; protein kinase binding

Biological Process: negative regulation of autophagy; apoptosis; cytokinesis; cellular process regulating host cell cycle in response to virus; germ cell development; apoptotic mitochondrial changes; regulation of mitochondrial membrane potential; ovarian follicle development; positive regulation of cell proliferation; negative regulation of neuron apoptosis; release of cytochrome c from mitochondria; in utero embryonic development; mitotic cell cycle checkpoint; suppression by virus of host apoptosis; male gonad development; endocytosis; cell proliferation; neuron apoptosis; fertilization; DNA damage response, signal transduction resulting in induction of apoptosis; response to cytokine stimulus; innate immune response; response to cycloheximide; spermatogenesis; regulation of mitochondrial membrane permeability; growth; negative regulation of apoptosis
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 Research Articles on BCL2L1    1. FBI-1 affects recruitment of SAM68 on the BCL-X transcript through an HDAC dependent mechanism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BCL2L1 antibodyPathways associated with anti-BCL2L1 antibody
 Reference Product  PubMed Publications
 BAX antibody  >2204 publications with BCL2L1 and BAX
 BAD antibody  >547 publications with BCL2L1 and BAD
 BID antibody  >342 publications with BCL2L1 and BID
 BAK1 antibody  >241 publications with BCL2L1 and BAK1
 TP53 antibody  >65 publications with BCL2L1 and TP53
 APAF1 antibody  >61 publications with BCL2L1 and APAF1
 BECN1 antibody  >53 publications with BCL2L1 and BECN1
 BIK antibody  >50 publications with BCL2L1 and BIK
 BBC3 antibody  >46 publications with BCL2L1 and BBC3
 BCL2L11 antibody  >8 publications with BCL2L1 and BCL2L11
 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway antibodies  BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
Diseases associated with anti-BCL2L1 antibodyOrgans/Tissues associated with anti-BCL2L1 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >841 publications with BCL2L1 and Carcinoma
 Necrosis Antibodies  >654 publications with BCL2L1 and Necrosis
 Nervous System Diseases Antibodies  >380 publications with BCL2L1 and Nervous System Diseases
 Gastrointestinal Diseases Antibodies  >296 publications with BCL2L1 and Gastrointestinal Diseases
 Brain Diseases Antibodies  >294 publications with BCL2L1 and Brain Diseases
 Breast Neoplasms Antibodies  >266 publications with BCL2L1 and Breast Neoplasms
 Liver Diseases Antibodies  >250 publications with BCL2L1 and Liver Diseases
 Neoplasms, Experimental Antibodies  >232 publications with BCL2L1 and Neoplasms, Experimental
 Inflammation Antibodies  >189 publications with BCL2L1 and Inflammation
 Liver Neoplasms Antibodies  >187 publications with BCL2L1 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1322 publications with BCL2L1 and Blood
 Brain Antibodies  >540 publications with BCL2L1 and Brain
 Liver Antibodies  >432 publications with BCL2L1 and Liver
 Lung Antibodies  >306 publications with BCL2L1 and Lung
 Bone Antibodies  >272 publications with BCL2L1 and Bone
 Vascular Antibodies  >265 publications with BCL2L1 and Vascular
 Muscle Antibodies  >235 publications with BCL2L1 and Muscle
 Heart Antibodies  >194 publications with BCL2L1 and Heart
 Kidney Antibodies  >168 publications with BCL2L1 and Kidney
 Skin Antibodies  >138 publications with BCL2L1 and Skin
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