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anti-BCL2L2 antibody :: Rabbit BCL2L2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2528832
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BCL2L2, Polyclonal Antibody

★Popular Item★
 Also Known As   

BCL2L2 Polyclonal Antibody

 Product Synonym Names    BCLW; BCL-W; PPP1R51; BCL2-L-2
 Product Gene Name   

anti-BCL2L2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601931
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    0.5mg/mL (lot specific)
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 Immunogen    Recombinant protein of human BCL2L2
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-BCL2L2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BCL2L2 antibody

   This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
 Product Categories/Family for anti-BCL2L2 antibody    Cancer; Cell biology
 Applications Tested/Suitable for anti-BCL2L2 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-BCL2L2 antibody    IHC: 1:15-1:50
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 Immunohistochemistry (IHC) of anti-BCL2L2 antibody    Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using BCL2L2 Polyclonal Antibody at dilution 1:15
anti-BCL2L2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-BCL2L2 antibody    Immunohistochemistry of paraffin-embedded Human liver cancer tissue using BCL2L2 Polyclonal Antibody at dilution 1:15
anti-BCL2L2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for BCL2L2. It may not necessarily be applicable to this product.
 NCBI GI #    315360668
 NCBI GeneID    599
 NCBI Accession #    NP_001186768.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001199839.1 [Other Products]
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 UniProt Secondary Accession #    Q2M3U0; Q5U0H4; A8K0F4 [Other Products]
 UniProt Related Accession #    Q92843 [Other Products]
 Molecular Weight    37,171 Da
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 NCBI Official Full Name    bcl-2-like protein 2
 NCBI Official Synonym Full Names    BCL2-like 2
 NCBI Official Symbol    BCL2L2 [Similar Products]
 NCBI Official Synonym Symbols   
BCLW; BCL-W; PPP1R51; BCL2-L-2
[Similar Products]
 NCBI Protein Information    bcl-2-like protein 2; apoptosis regulator BCL-W; protein phosphatase 1, regulatory subunit 51
 UniProt Protein Name    Bcl-2-like protein 2
 UniProt Synonym Protein Names   
Apoptosis regulator Bcl-W
 Protein Family    Bcl-2-like protein
 UniProt Gene Name    BCL2L2 [Similar Products]
 UniProt Synonym Gene Names    BCLW; KIAA0271; Bcl2-L-2 [Similar Products]
 UniProt Entry Name    B2CL2_HUMAN
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 NCBI Summary for BCL2L2    This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
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 UniProt Comments for BCL2L2    BCL2L2: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. Expressed in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. Belongs to the Bcl-2 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q11.2-q12

Cellular Component: mitochondrial outer membrane; cytosol

Molecular Function: BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; spermatogenesis; Sertoli cell proliferation; negative regulation of apoptosis
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 Research Articles on BCL2L2    1. A structural basis for a conserved binding mechanism between p53DBD and the anti-apoptotic Bcl-2 family proteins.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BCL2L2 antibodyPathways associated with anti-BCL2L2 antibody
 Reference Product  PubMed Publications
 BAX antibody  >51 publications with BCL2L2 and BAX
 BAD antibody  >26 publications with BCL2L2 and BAD
 MCL1 antibody  >14 publications with BCL2L2 and MCL1
 BID antibody  >14 publications with BCL2L2 and BID
 TP53 antibody  >7 publications with BCL2L2 and TP53
 BIK antibody  >3 publications with BCL2L2 and BIK
 BBC3 antibody  >3 publications with BCL2L2 and BBC3
 BCL2L11 antibody  >1 publications with BCL2L2 and BCL2L11
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
Diseases associated with anti-BCL2L2 antibodyOrgans/Tissues associated with anti-BCL2L2 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >11 publications with BCL2L2 and Necrosis
 Liver Neoplasms Antibodies  >9 publications with BCL2L2 and Liver Neoplasms
 Liver Diseases Antibodies  >9 publications with BCL2L2 and Liver Diseases
 Lung Neoplasms Antibodies  >8 publications with BCL2L2 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >7 publications with BCL2L2 and Carcinoma, Hepatocellular
 Glioma Antibodies  >7 publications with BCL2L2 and Glioma
 Disease Models, Animal Antibodies  >7 publications with BCL2L2 and Disease Models, Animal
 Breast Neoplasms Antibodies  >5 publications with BCL2L2 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with BCL2L2 and Neoplasms, Experimental
 Nerve Degeneration Antibodies  >4 publications with BCL2L2 and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >28 publications with BCL2L2 and Brain
 Blood Antibodies  >20 publications with BCL2L2 and Blood
 Lung Antibodies  >12 publications with BCL2L2 and Lung
 Testis Antibodies  >12 publications with BCL2L2 and Testis
 Liver Antibodies  >10 publications with BCL2L2 and Liver
 Intestine Antibodies  >10 publications with BCL2L2 and Intestine
 Embryonic Tissue Antibodies  >5 publications with BCL2L2 and Embryonic Tissue
 Stomach Antibodies  >5 publications with BCL2L2 and Stomach
 Vascular Antibodies  >4 publications with BCL2L2 and Vascular
 Muscle Antibodies  >4 publications with BCL2L2 and Muscle
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