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anti-BD-2 antibody :: Goat anti-Human BD-2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS691384 anti-BD-2 antibody
Unit / Price
0.1 mg  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BD-2, Polyclonal Antibody

 Also Known As   

Goat Anti-Human BD-2

 Product Synonym Names    Antigen-Affinity Purified Polyclonal Antibodies Anti-human BD-2
 Product Gene Name   

anti-BD-2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 8; NC_000008.11 (7414863..7416832, complement). Location: 8p23.1
 OMIM    602215
 3D Structure    ModBase 3D Structure for O15263
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Human
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 Purity/Purification    Affinity chromatography
 Form/Format    Lyophilized
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 Antibody Generation    Produced from sera of goats pre-immunized with highly pure (>98%) recombinant hBD-2. Anti-hBD-2 specific antibody was purified by affinity chromatography employing immobilized hBD-2 matrix.
 Buffer    PBS; pH 7.2
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 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-BD-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BD-2 antibody

   Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, six human beta-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and in some cases, a propeptide sequence. beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.
 Applications Tested/Suitable for anti-BD-2 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-BD-2 antibody    Western Blot: To detect hBD-2 by Western Blot analysis this antibody can be used at a concentration of 0.1- 0.2 ėg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hBD-2 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions
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NCBI/Uniprot data below describe general gene information for BD-2. It may not necessarily be applicable to this product.
 NCBI GI #    327532771
 NCBI GeneID    100289462
 NCBI Accession #    NP_001192195.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001205266.1 [Other Products]
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 UniProt Primary Accession #    O15263 [Other Products]
 UniProt Secondary Accession #    Q52LC0 [Other Products]
 Molecular Weight    7,038 Da
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 NCBI Official Full Name    beta-defensin 4B
 NCBI Official Synonym Full Names    defensin, beta 4B
 NCBI Official Symbol    DEFB4B [Similar Products]
 NCBI Official Synonym Symbols   
DEFB4P
[Similar Products]
 NCBI Protein Information    beta-defensin 4B; defensin, beta 4, pseudogene
 UniProt Protein Name    Beta-defensin 4A
 UniProt Synonym Protein Names   
Beta-defensin 2; BD-2; hBD-2; Defensin, beta 2; Skin-antimicrobial peptide 1
 UniProt Gene Name    DEFB4A [Similar Products]
 UniProt Synonym Gene Names    DEFB102; DEFB2; DEFB4; BD-2; hBD-2; SAP1 [Similar Products]
 UniProt Entry Name    DFB4A_HUMAN
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 NCBI Summary for BD-2    Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Oct 2014]
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 UniProt Comments for BD-2    Function: Has antibacterial activity

Potential.

Subcellular location: Secreted.

Tissue specificity: Expressed in the skin and respiratory tract.

Induction: By inflammation.

Sequence similarities: Belongs to the beta-defensin family. LAP/TAP subfamily.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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