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anti-BDNF antibody :: Rabbit BDNF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS223691 anti-BDNF antibody
Unit / Price
0.05 mg  /  $540 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BDNF, Polyclonal Antibody

 Also Known As   

RABBIT ANTI HUMAN BDNF:Biotin

 Product Gene Name   

anti-BDNF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    113505
 3D Structure    ModBase 3D Structure for P23560
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
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 Form/Format    Biotin
Purified IgG conjugated to Biotin - lyophilised
 Concentration    IgG concentration 0.1mg/ml after reconstitution (lot specific)
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 Reconstitution    Reconstitute with 0.5ml sterile PBS containing 0.1% bovine serum albumin. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended.
 Immunogen    Recombinant human BDNF
Buffer Solution
 Antiserum Preparation    Antiserum to human BDNF were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
 Other Notes    Small volumes of anti-BDNF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-BDNF antibody

   Rabbit anti Human BDNF antibody recognizes human BDNF (brain-derived neurotrophic factor), a potent neurotrophin and member of the NGF-beta family, secreted from dense core vesicles, which promotes the growth, differentiation and survival of neurons within, or directly connected to, the central nervous system (CNS). BDNF signals through binding to the high affinity receptor trkB, and also binds to the low affinity neurotrophin receptor LNGFR. Studies have shown the involvement of BDNF in the modulation of short-term synaptic function and in the formation of long-term memory, and reduced levels of BDNF are seen in patients with Alzheimer's and Huntington disease.
 Applications Tested/Suitable for anti-BDNF antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-BDNF antibody    ELISA: This biotinylated human BDNF antibody may be used in a direct ELISA or as the detection reagent in a sandwich ELISA with our purified human BDNF antibody as the capture reagent and recombinant human BDNF as the standard.
ELISA: Minimum Dilution: 0.25; Maximum Dilution: 1.0ug/ml
Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml
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NCBI/Uniprot data below describe general gene information for BDNF. It may not necessarily be applicable to this product.
 NCBI GI #    219842288
 NCBI GeneID    627
 NCBI Accession #    NP_001137277.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001143805.1 [Other Products]
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 UniProt Primary Accession #    P23560 [Other Products]
 UniProt Secondary Accession #    Q598Q1; Q6DN19; Q6YNR2; Q6YNR3; Q9BYY7; Q9UC24; A7LA85; A7LA92; D3DQZ2 [Other Products]
 UniProt Related Accession #    P23560 [Other Products]
 Molecular Weight    31,116 Da
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 NCBI Official Full Name    brain-derived neurotrophic factor isoform a preproprotein
 NCBI Official Synonym Full Names    brain-derived neurotrophic factor
 NCBI Official Symbol    BDNF [Similar Products]
 NCBI Official Synonym Symbols   
ANON2; BULN2
[Similar Products]
 NCBI Protein Information    brain-derived neurotrophic factor; abrineurin; neurotrophin
 UniProt Protein Name    Brain-derived neurotrophic factor
 UniProt Synonym Protein Names   
Abrineurin
 Protein Family    BDNF/NT-3 growth factors receptor
 UniProt Gene Name    BDNF [Similar Products]
 UniProt Synonym Gene Names    BDNF [Similar Products]
 UniProt Entry Name    BDNF_HUMAN
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 NCBI Summary for BDNF    The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
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 UniProt Comments for BDNF    BDNF: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases. Belongs to the NGF-beta family. 5 isoforms of the human protein are produced by alternative promoter.

Protein type: Cytokine; Secreted; Cell development/differentiation; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: extracellular space; synaptic vesicle; mitochondrial crista; perinuclear region of cytoplasm; dendrite; cytoplasm; cytoplasmic membrane-bound vesicle; extracellular region; terminal button; perikaryon

Molecular Function: growth factor activity; neurotrophin TRKB receptor binding

Biological Process: circadian rhythm; axon guidance; mechanoreceptor differentiation; behavioral fear response; mitochondrial electron transport, NADH to ubiquinone; axon extension; regulation of neuron differentiation; response to hormone stimulus; positive regulation of long-term neuronal synaptic plasticity; response to vitamin A; negative regulation of neuroblast proliferation; ureteric bud development; dendrite development; regulation of retinal cell programmed cell death; feeding behavior; negative regulation of neuron apoptosis; negative regulation of synaptic transmission, GABAergic; response to electrical stimulus; inner ear development; response to food; nervous system development; chronic inflammatory response; response to light intensity; neuron recognition; learning; regulation of short-term neuronal synaptic plasticity; regulation of axon extension; negative regulation of striated muscle development; positive regulation of peptidyl-serine phosphorylation; positive regulation of synaptogenesis; response to hyperoxia; axon target recognition; glutamate secretion; response to hypoxia; response to fluoxetine; nerve development; response to activity; regulation of excitatory postsynaptic membrane potential; positive regulation of neuron differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; neurite morphogenesis; gamma-aminobutyric acid signaling pathway

Disease: Bulimia Nervosa, Susceptibility To, 1; Obsessive-compulsive Disorder; Bulimia Nervosa, Susceptibility To, 2; Central Hypoventilation Syndrome, Congenital
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 Research Articles on BDNF    1. BDNF Met allele carriers were, in general, more sensitive to the effects of parental rearing compared to Val/Val carriers in relation to anxiety and somatization.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-BDNF antibodyDiseases associated with anti-BDNF antibody
 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3760 publications with BDNF and Nervous System Diseases
 Brain Injuries Antibodies  >861 publications with BDNF and Brain Injuries
 Depressive Disorder Antibodies  >711 publications with BDNF and Depressive Disorder
 Schizophrenia Antibodies  >599 publications with BDNF and Schizophrenia
 Cognition Disorders Antibodies  >588 publications with BDNF and Cognition Disorders
 Body Weight Antibodies  >584 publications with BDNF and Body Weight
 Brain Ischemia Antibodies  >575 publications with BDNF and Brain Ischemia
 Inflammation Antibodies  >573 publications with BDNF and Inflammation
 Memory Disorders Antibodies  >559 publications with BDNF and Memory Disorders
 Nerve Degeneration Antibodies  >552 publications with BDNF and Nerve Degeneration
Organs/Tissues associated with anti-BDNF antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14493 publications with BDNF and Brain
 Eye Antibodies  >644 publications with BDNF and Eye
 Embryonic Tissue Antibodies  >566 publications with BDNF and Embryonic Tissue
 Heart Antibodies  >183 publications with BDNF and Heart
 Skin Antibodies  >151 publications with BDNF and Skin
 Connective Tissue Antibodies  >119 publications with BDNF and Connective Tissue
 Lung Antibodies  >118 publications with BDNF and Lung
 Liver Antibodies  >102 publications with BDNF and Liver
 Thyroid Antibodies  >84 publications with BDNF and Thyroid
 Adrenal Gland Antibodies  >70 publications with BDNF and Adrenal Gland
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