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anti-BDNF antibody :: Chicken BDNF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS535248
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $455 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BDNF, Polyclonal Antibody

 Also Known As   

BDNF antibody

 Product Synonym Names    Polyclonal BDNF; Anti-BDNF; Brain Derived Neurotrophic Factor
 Product Gene Name   

anti-BDNF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    113505
 3D Structure    ModBase 3D Structure for P23560
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 Clonality    Polyclonal
 Isotype    IgY
 Host    Chicken
 Species Reactivity    To be determined by end-user
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 Form/Format    Supplied as a liquid.
 Concentration    1.0 mg/ml (lot specific)
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 Biological Significance    Brain-derived Neurotrophic Factor (BDNF) is a member of the NGF family of neurotrophic factors. BDNF, NGF, NT-3, and NT-4/5 are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. High levels of expression of BDNF have been detected in the hippocampus, cerebellum, fetal eye, and placenta.
 Immunogen    BDNF antibody was raised in chicken using recombinant human brain-derived neurotrophic factor as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-BDNF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BDNF antibody

   Chicken polyclonal BDNF antibody
 Product Categories/Family for anti-BDNF antibody    Cytokines & Growth Factors
 Applications Tested/Suitable for anti-BDNF antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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 Immunohistochemistry (IHC) of anti-BDNF antibody    BDNF was detected in perfusion fixed frozen sections of rat spinal cord (dilution 7 ugmL) overnight at 4 deg C. Tissue was stained (brown) and counterstained with hematoxylin (blue). Specific labeling was localized to spinal cord dorsal horn.
anti-BDNF antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for BDNF. It may not necessarily be applicable to this product.
 NCBI GI #    179407
 NCBI GeneID    627
 NCBI Accession #    AAA96140.1 [Other Products]
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 UniProt Primary Accession #    P23560 [Other Products]
 UniProt Secondary Accession #    Q598Q1; Q6DN19; Q6YNR2; Q6YNR3; Q9BYY7; Q9UC24; A7LA85; A7LA92; D3DQZ2 [Other Products]
 UniProt Related Accession #    P23560 [Other Products]
 Molecular Weight    31,116 Da
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 NCBI Official Full Name    brain-derived neurotrophic factor
 NCBI Official Synonym Full Names    brain-derived neurotrophic factor
 NCBI Official Symbol    BDNF [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    brain-derived neurotrophic factor
 UniProt Protein Name    Brain-derived neurotrophic factor
 UniProt Synonym Protein Names   
 Protein Family    BDNF/NT-3 growth factors receptor
 UniProt Gene Name    BDNF [Similar Products]
 UniProt Synonym Gene Names    BDNF [Similar Products]
 UniProt Entry Name    BDNF_HUMAN
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 NCBI Summary for BDNF    The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
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 UniProt Comments for BDNF    BDNF: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases. Belongs to the NGF-beta family. 5 isoforms of the human protein are produced by alternative promoter.

Protein type: Secreted; Cytokine; Secreted, signal peptide; Cell development/differentiation

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: extracellular space; synaptic vesicle; mitochondrial crista; perinuclear region of cytoplasm; dendrite; cytoplasm; cytoplasmic membrane-bound vesicle; extracellular region; terminal button; perikaryon

Molecular Function: growth factor activity; neurotrophin TRKB receptor binding

Biological Process: circadian rhythm; axon guidance; mechanoreceptor differentiation; behavioral fear response; mitochondrial electron transport, NADH to ubiquinone; axon extension; regulation of neuron differentiation; response to hormone stimulus; positive regulation of long-term neuronal synaptic plasticity; response to vitamin A; negative regulation of neuroblast proliferation; ureteric bud development; dendrite development; regulation of retinal cell programmed cell death; feeding behavior; negative regulation of neuron apoptosis; negative regulation of synaptic transmission, GABAergic; response to electrical stimulus; inner ear development; response to food; nervous system development; chronic inflammatory response; response to light intensity; neuron recognition; regulation of short-term neuronal synaptic plasticity; learning; regulation of axon extension; negative regulation of striated muscle development; positive regulation of peptidyl-serine phosphorylation; positive regulation of synaptogenesis; response to hyperoxia; axon target recognition; glutamate secretion; response to hypoxia; response to fluoxetine; nerve development; response to activity; positive regulation of neuron differentiation; regulation of excitatory postsynaptic membrane potential; gamma-aminobutyric acid signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; neurite morphogenesis

Disease: Bulimia Nervosa, Susceptibility To, 1; Obsessive-compulsive Disorder; Bulimia Nervosa, Susceptibility To, 2; Central Hypoventilation Syndrome, Congenital
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 Research Articles on BDNF    1. In schizophrenic patients, serum BDNF levels were significantly increased following a 12 exercise program.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-BDNF antibodyDiseases associated with anti-BDNF antibody
 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3902 publications with BDNF and Nervous System Diseases
 Brain Injuries Antibodies  >883 publications with BDNF and Brain Injuries
 Depressive Disorder Antibodies  >747 publications with BDNF and Depressive Disorder
 Schizophrenia Antibodies  >632 publications with BDNF and Schizophrenia
 Inflammation Antibodies  >626 publications with BDNF and Inflammation
 Cognition Disorders Antibodies  >624 publications with BDNF and Cognition Disorders
 Brain Ischemia Antibodies  >611 publications with BDNF and Brain Ischemia
 Body Weight Antibodies  >611 publications with BDNF and Body Weight
 Memory Disorders Antibodies  >587 publications with BDNF and Memory Disorders
 Nerve Degeneration Antibodies  >557 publications with BDNF and Nerve Degeneration
Organs/Tissues associated with anti-BDNF antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15106 publications with BDNF and Brain
 Eye Antibodies  >656 publications with BDNF and Eye
 Embryonic Tissue Antibodies  >570 publications with BDNF and Embryonic Tissue
 Heart Antibodies  >205 publications with BDNF and Heart
 Skin Antibodies  >157 publications with BDNF and Skin
 Lung Antibodies  >123 publications with BDNF and Lung
 Connective Tissue Antibodies  >123 publications with BDNF and Connective Tissue
 Liver Antibodies  >107 publications with BDNF and Liver
 Thyroid Antibodies  >87 publications with BDNF and Thyroid
 Adrenal Gland Antibodies  >76 publications with BDNF and Adrenal Gland
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