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anti-BDNF antibody :: Rabbit BDNF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9413508
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BDNF, Polyclonal Antibody

★Popular Item★
 Also Known As   

BDNF Antibody

 Product Synonym Names    BDNF; MGC34632
 Product Gene Name   

anti-BDNF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    113505
 3D Structure    ModBase 3D Structure for P23560
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    The antibody detects endogenous level of total BDNF protein.
 Purity/Purification    Antibodies were purified by affinity purification using immunogen.
 Form/Format    Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen Type    Recombinant Protein
 Immunogen Description    Recombinant protein of human BDNF.
 Target Name    BDNF
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-BDNF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BDNF antibody

   Neurotrophins function to regulate naturally occurring cell death of neurons during development. The prototype neurotrophin is nerve growth factor (NGF), originally discovered in the 1950s as a soluble peptide promoting the survival of, and neurite outgrowth from, sympathetic ganglia. Three additional structurally homologous neurotrophic factors have been identified. These include brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) (also designated NT-5). These various neurotrophins stimulate the in vitro survival of distinct, but partially overlapping, populations of neurons. The cell surface receptors through which neurotrophins mediate their activity have been identified. For instance, the Trk A receptor is the preferential receptor for NGF, but also binds NT-3 and NT-4. The Trk B receptor binds both BDNF and NT-4 equally well, and binds NT-3 to a lesser extent, while the Trk C receptor only binds NT-3.
 Product Categories/Family for anti-BDNF antibody    Total protein Ab
 Applications Tested/Suitable for anti-BDNF antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-BDNF antibody    Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:100
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 Western Blot (WB) of anti-BDNF antibody    Western blot analysis of extracts of SH-SY5Y cell and PC-12 cell lines, using BDNF antibody.
anti-BDNF antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-BDNF antibody    Immunohistochemical analysis of paraffin-embedded rat lung using BDNF antibody at dilution of 1:100 (200x lens).
anti-BDNF antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-BDNF antibody    Immunohistochemical analysis of paraffin-embedded human esophagus using BDNF antibody at dilution of 1:100 (200x lens).
anti-BDNF antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for BDNF. It may not necessarily be applicable to this product.
 NCBI GI #    219842288
 NCBI GeneID    627
 NCBI Accession #    NP_001137277.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001143805.1 [Other Products]
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 UniProt Primary Accession #    P23560 [Other Products]
 UniProt Secondary Accession #    Q598Q1; Q6DN19; Q6YNR2; Q6YNR3; Q9BYY7; Q9UC24; A7LA85; A7LA92; D3DQZ2 [Other Products]
 UniProt Related Accession #    P23560 [Other Products]
 Molecular Weight    28kd
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 NCBI Official Full Name    brain-derived neurotrophic factor isoform a preproprotein
 NCBI Official Synonym Full Names    brain-derived neurotrophic factor
 NCBI Official Symbol    BDNF [Similar Products]
 NCBI Official Synonym Symbols   
ANON2; BULN2
[Similar Products]
 NCBI Protein Information    brain-derived neurotrophic factor
 UniProt Protein Name    Brain-derived neurotrophic factor
 UniProt Synonym Protein Names   
Abrineurin
 Protein Family    BDNF/NT-3 growth factors receptor
 UniProt Gene Name    BDNF [Similar Products]
 UniProt Synonym Gene Names    BDNF [Similar Products]
 UniProt Entry Name    BDNF_HUMAN
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 NCBI Summary for BDNF    The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
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 UniProt Comments for BDNF    BDNF: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases. Belongs to the NGF-beta family. 5 isoforms of the human protein are produced by alternative promoter.

Protein type: Secreted; Secreted, signal peptide; Cytokine; Cell development/differentiation

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: extracellular space; mitochondrial crista; synaptic vesicle; perinuclear region of cytoplasm; dendrite; cytoplasmic membrane-bound vesicle; cytoplasm; extracellular region; terminal button; perikaryon

Molecular Function: growth factor activity; neurotrophin TRKB receptor binding

Biological Process: circadian rhythm; axon guidance; mechanoreceptor differentiation; behavioral fear response; mitochondrial electron transport, NADH to ubiquinone; regulation of neuron differentiation; axon extension; response to hormone stimulus; positive regulation of long-term neuronal synaptic plasticity; response to vitamin A; negative regulation of neuroblast proliferation; ureteric bud development; dendrite development; regulation of retinal cell programmed cell death; feeding behavior; negative regulation of neuron apoptosis; response to electrical stimulus; negative regulation of synaptic transmission, GABAergic; inner ear development; response to food; nervous system development; chronic inflammatory response; response to light intensity; neuron recognition; regulation of axon extension; learning; regulation of short-term neuronal synaptic plasticity; negative regulation of striated muscle development; positive regulation of peptidyl-serine phosphorylation; positive regulation of synaptogenesis; axon target recognition; response to hyperoxia; glutamate secretion; response to hypoxia; response to fluoxetine; nerve development; response to activity; positive regulation of neuron differentiation; regulation of excitatory postsynaptic membrane potential; neurite morphogenesis; gamma-aminobutyric acid signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Bulimia Nervosa, Susceptibility To, 1; Obsessive-compulsive Disorder; Bulimia Nervosa, Susceptibility To, 2; Central Hypoventilation Syndrome, Congenital
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 Research Articles on BDNF    1. BDNF seems to be associated with periodontal disease process
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BDNF antibodyPathways associated with anti-BDNF antibody
 Reference Product  PubMed Publications
 NTRK2 antibody  >94 publications with BDNF and NTRK2
 CREB1 antibody  >79 publications with BDNF and CREB1
 NGFR antibody  >49 publications with BDNF and NGFR
 CDC42 antibody  >24 publications with BDNF and CDC42
 NTF3 antibody  >22 publications with BDNF and NTF3
 NTRK1 antibody  >15 publications with BDNF and NTRK1
 NTF4 antibody  >14 publications with BDNF and NTF4
 NTRK3 antibody  >12 publications with BDNF and NTRK3
 PLCG1 antibody  >2 publications with BDNF and PLCG1
 SORT1 antibody  >1 publications with BDNF and SORT1
 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
Diseases associated with anti-BDNF antibodyOrgans/Tissues associated with anti-BDNF antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3999 publications with BDNF and Nervous System Diseases
 Brain Injuries Antibodies  >905 publications with BDNF and Brain Injuries
 Depressive Disorder Antibodies  >772 publications with BDNF and Depressive Disorder
 Inflammation Antibodies  >649 publications with BDNF and Inflammation
 Cognition Disorders Antibodies  >644 publications with BDNF and Cognition Disorders
 Schizophrenia Antibodies  >640 publications with BDNF and Schizophrenia
 Body Weight Antibodies  >634 publications with BDNF and Body Weight
 Brain Ischemia Antibodies  >623 publications with BDNF and Brain Ischemia
 Memory Disorders Antibodies  >608 publications with BDNF and Memory Disorders
 Nerve Degeneration Antibodies  >564 publications with BDNF and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15375 publications with BDNF and Brain
 Eye Antibodies  >662 publications with BDNF and Eye
 Embryonic Tissue Antibodies  >572 publications with BDNF and Embryonic Tissue
 Heart Antibodies  >208 publications with BDNF and Heart
 Skin Antibodies  >158 publications with BDNF and Skin
 Connective Tissue Antibodies  >127 publications with BDNF and Connective Tissue
 Lung Antibodies  >125 publications with BDNF and Lung
 Liver Antibodies  >109 publications with BDNF and Liver
 Thyroid Antibodies  >87 publications with BDNF and Thyroid
 Adrenal Gland Antibodies  >76 publications with BDNF and Adrenal Gland
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