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anti-ARRB2 antibody :: Goat BETA ARRESTIN-2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS223712
Testing Data #1
Unit / Price
0.1 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BETA ARRESTIN-2 (ARRB2), Polyclonal Antibody

 Also Known As   

GOAT ANTI HUMAN BETA ARRESTIN-2

 Product Gene Name   

anti-ARRB2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107941
 3D Structure    ModBase 3D Structure for P32121
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Mouse (Expected from Sequence), Rat (Expected from Sequence)
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 Specificity    This item specifically recognises human beta arrestin-2 (ARRB2), a scaffolding protein and member of the arrestin family, highly expressed in the central nervous system, which plays a role in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling, through receptor desensitization and internalization.

ARRB2 may function in the regulation of synaptic receptors, and in scaffold-linking GPCRs to JNK3, thereby enhancing the GPCR-mediated activation of JNK3, associated with cell apoptosis.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 0.5mg/ml (lot specific)
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 Perservative Stabilisers    0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin
 Immunogen    Synthetic peptide sequence C-HDHIPLPRPQS from the internal region of the ARRB2 (NP_004304.1; NP_945355.)1.
Buffer Solution
 Antiserum Preparation    Antiserum to human Beta arrestin-2 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-ARRB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ARRB2 antibody

   MBS223712 specifically recognises human beta arrestin-2 (ARRB2), a scaffolding protein and member of the arrestin family, highly expressed in the central nervous system, which plays a role in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling, through receptor desensitization and internalization. ARRB2 may function in the regulation of synaptic receptors, and in scaffold-linking GPCRs to JNK3, thereby enhancing the GPCR-mediated activation of JNK3, associated with cell apoptosis.
 Applications Tested/Suitable for anti-ARRB2 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ARRB2 antibody    Western Blot: This item detects a band of approximately 45kDa in human brain, skin and spleen cell lysates.
ELISA: Minimum Dilution: 1/32000
Western Blotting: Minimum Dilution: 0.03; Maximum Dilution: 0.1ug/ml
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 Testing Data #1 of anti-ARRB2 antibody    Human spleen probed with Goat anti human Beta arrestin-2 (MBS223712)
anti-ARRB2 antibody Testing Data #1 image
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NCBI/Uniprot data below describe general gene information for ARRB2. It may not necessarily be applicable to this product.
 NCBI GI #    382545144
 NCBI GeneID    409
 NCBI Accession #    NP_001244257.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001257328.1 [Other Products]
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 UniProt Primary Accession #    P32121 [Other Products]
 UniProt Secondary Accession #    Q0Z8D3; Q2PP19; Q6ICT3; Q8N7Y2; Q9UEQ6; B4DLW0; B5B0C0; B7WPL3; D3DTK2; H0Y688 [Other Products]
 UniProt Related Accession #    P32121 [Other Products]
 Molecular Weight    44,392 Da [Similar Products]
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 NCBI Official Full Name    beta-arrestin-2 isoform 3
 NCBI Official Synonym Full Names    arrestin, beta 2
 NCBI Official Symbol    ARRB2 [Similar Products]
 NCBI Official Synonym Symbols   
ARB2; ARR2; BARR2
[Similar Products]
 NCBI Protein Information    beta-arrestin-2; arrestin 3; arrestin beta-2
 UniProt Protein Name    Beta-arrestin-2
 UniProt Synonym Protein Names   
Arrestin beta-2
 Protein Family    Beta-arrestin
 UniProt Gene Name    ARRB2 [Similar Products]
 UniProt Synonym Gene Names    ARB2; ARR2 [Similar Products]
 UniProt Entry Name    ARRB2_HUMAN
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 NCBI Summary for ARRB2    Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
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 UniProt Comments for ARRB2    ARRB2: a member of the arrestin/beta-arrestin protein family. These proteins participate in agonist-mediated desensitization of G-protein-coupled receptors. Acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Expressed at high levels in the CNS and peripheral blood leukocytes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: postsynaptic membrane; endocytic vesicle; basolateral plasma membrane; cytoplasm; postsynaptic density; plasma membrane; dendritic spine; coated pit; cytoplasmic vesicle; nucleus; cytosol

Molecular Function: angiotensin receptor binding; protein domain specific binding; protein kinase B binding; protein binding; enzyme binding; G-protein-coupled receptor binding; type 2A serotonin receptor binding; follicle stimulating hormone receptor binding; ubiquitin protein ligase binding; protein complex binding; mitogen-activated protein kinase binding; alpha-1B adrenergic receptor binding; type 1 angiotensin receptor binding; protein complex scaffold; D1 dopamine receptor binding; alpha-1A adrenergic receptor binding; receptor binding

Biological Process: transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; follicle-stimulating hormone signaling pathway; positive regulation of receptor internalization; protein ubiquitination; negative regulation of caspase activity; adult walking behavior; protein transport; receptor internalization; transforming growth factor beta receptor signaling pathway; negative regulation of interleukin-6 production; detection of temperature stimulus involved in sensory perception of pain; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; platelet activation; negative regulation of interleukin-12 production; Notch signaling pathway; negative regulation of natural killer cell mediated cytotoxicity; positive regulation of synaptic transmission, dopaminergic; negative regulation of interleukin-1 beta production; negative regulation of tumor necrosis factor production; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; G-protein coupled receptor internalization; inhibition of NF-kappaB transcription factor; positive regulation of protein ubiquitination; negative regulation of toll-like receptor signaling pathway; negative regulation of protein ubiquitination; brain development; positive regulation of calcium ion transport; blood coagulation
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 Research Articles on ARRB2    1. Identification of receptor binding-induced conformational changes in non-visual arrestins.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ARRB2 antibodyPathways associated with anti-ARRB2 antibody
 Reference Product  PubMed Publications
 ADRB2 antibody  >4 publications with ARRB2 and ADRB2
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Activation Of SMO Pathway antibodies  Activation Of SMO Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Atypical NF-kappaB Pathway antibodies  Atypical NF-kappaB Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
Diseases associated with anti-ARRB2 antibodyOrgans/Tissues associated with anti-ARRB2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with ARRB2 and Inflammation
 Brain Diseases Antibodies  >4 publications with ARRB2 and Brain Diseases
 Poisoning Antibodies  >3 publications with ARRB2 and Poisoning
 Amphetamine-Related Disorders Antibodies  >3 publications with ARRB2 and Amphetamine-Related Disorders
 Liver Diseases Antibodies  >2 publications with ARRB2 and Liver Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >2 publications with ARRB2 and Drug-Related Side Effects and Adverse Reactions
 Myocardial Ischemia Antibodies  >1 publications with ARRB2 and Myocardial Ischemia
 Kidney Diseases Antibodies  >1 publications with ARRB2 and Kidney Diseases
 Hyperalgesia Antibodies  >1 publications with ARRB2 and Hyperalgesia
 Drug-Induced Liver Injury Antibodies  >1 publications with ARRB2 and Drug-Induced Liver Injury
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with ARRB2 and Brain
 Blood Antibodies  >6 publications with ARRB2 and Blood
 Bone Antibodies  >5 publications with ARRB2 and Bone
 Liver Antibodies  >4 publications with ARRB2 and Liver
 Lung Antibodies  >3 publications with ARRB2 and Lung
 Kidney Antibodies  >3 publications with ARRB2 and Kidney
 Eye Antibodies  >2 publications with ARRB2 and Eye
 Bone Marrow Antibodies  >2 publications with ARRB2 and Bone Marrow
 Nerve Antibodies  >2 publications with ARRB2 and Nerve
 Skin Antibodies  >2 publications with ARRB2 and Skin
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