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anti-BHLHA15 antibody :: Rabbit BHLHA15 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS153611
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BHLHA15, Polyclonal Antibody

★Popular Item★
 Also Known As   

BHLHA15 Antibody

 Product Synonym Names    BHLHA15; MIST1; BHLHB8; MIST1; Class A basic helix-loop-helix protein 15; Class B basic helix-loop-helix protein 8; bHLHa15; basic helix-loop-helix family, member a15
 Product Gene Name   

anti-BHLHA15 antibody

[Similar Products]
 Antibody/Peptide Pairs    BHLHA15 peptide (MBS153989) is used for blocking the activity of BHLHA15 antibody (MBS153611)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    60-110
 OMIM    608606
 3D Structure    ModBase 3D Structure for Q7RTS1
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    BHLHA15 antibody is human, mouse and rat reactive.
 Purity/Purification    BHLHA15 antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    BHLHA15 antibody was raised against a 18 amino acid peptide near the center of human BHLHA15.
 Buffer    BHLHA15 antibody is supplied in PBS containing 0.02% sodium azide.
 Positive Control    Rat Small Intestine Tissue Lysate: MBS151680
Human small Intestine Tissue Slide: MBS154284
 Homology    Predicted species reactivity based on immunogen sequence: Bovine: (71%)
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 Preparation and Storage    BHLHA15 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
 Other Notes    Small volumes of anti-BHLHA15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BHLHA15 antibody

   BHLHA15 (basic helix-loop-helix protein 15), also known as MIST1 (muscle intestine and stomach expression 1) belongs to the bHLH family of transcription factors and plays a role in regulating the transcriptional activity of MYOD1 in muscle cell development as well as serving as a key regulator of acinar cell function (1,2). BHLHA15 contains a basic helix-loop-helix (bHLH) domain and is capable of binding to E-box motifs as a homodimer or a heterodimer with E-proteins. It may also negatively regulate bHLH-mediated transcription through a N-terminal repressor domain (3). It is expressed in mammary epithelial cells and is essential for the regulation of mammary gland development (4).
 Applications Tested/Suitable for anti-BHLHA15 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-BHLHA15 antibody    BHLHA15 antibody can be used for detection of BHLHA15 by Western blot at 1 - 2 ug/ml. Antibody can also be used for Immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.
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 Western Blot (WB) of anti-BHLHA15 antibody    Western blot analysis of BHLHA15 in rat small Intestine tissue lysate with BHLHA15 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide
anti-BHLHA15 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-BHLHA15 antibody    Immunohistochemistry of BHLHA15 in human small intestine tissue with BHLHA15 antibody at 5 μg/mL.
anti-BHLHA15 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence of anti-BHLHA15 antibody    Immunofluorescence of BHLHA15 in human small intestine tissue with BHLHA15 antibody at 20 ug/mL.
anti-BHLHA15 antibody Immunofluorescence image
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NCBI/Uniprot data below describe general gene information for BHLHA15. It may not necessarily be applicable to this product.
 NCBI GI #    29126247
 NCBI GeneID    168620
 NCBI Accession #    NP_803238 [Other Products]
 NCBI GenBank Nucleotide #    NM_177455.3 [Other Products]
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 UniProt Primary Accession #    Q7RTS1 [Other Products]
 UniProt Secondary Accession #    Q14DE4; A4D271 [Other Products]
 UniProt Related Accession #    Q7RTS1 [Other Products]
 Molecular Weight    Predicted: 21 kDa

Observed: 24 kDa
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 NCBI Official Full Name    class A basic helix-loop-helix protein 15
 NCBI Official Synonym Full Names    basic helix-loop-helix family, member a15
 NCBI Official Symbol    BHLHA15 [Similar Products]
 NCBI Official Synonym Symbols   
MIST1; BHLHB8
[Similar Products]
 NCBI Protein Information    class A basic helix-loop-helix protein 15; MIST-1; class II bHLH protein MIST1; class B basic helix-loop-helix protein 8; muscle, intestine and stomach expression 1; basic helix-loop-helix domain containing, class B, 8
 UniProt Protein Name    Class A basic helix-loop-helix protein 15
 UniProt Synonym Protein Names   
Class B basic helix-loop-helix protein 8; bHLHb8; Muscle, intestine and stomach expression 1; MIST-1
 Protein Family    Class A basic helix-loop-helix protein
 UniProt Gene Name    BHLHA15 [Similar Products]
 UniProt Synonym Gene Names    BHLHB8; MIST1; bHLHa15; bHLHb8; MIST-1 [Similar Products]
 UniProt Entry Name    BHA15_HUMAN
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 UniProt Comments for BHLHA15    MIST1: Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3'.

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: nucleus

Molecular Function: protein homodimerization activity

Biological Process: G-protein coupled receptor protein signaling pathway; cellular response to glucose starvation; transcription, DNA-dependent; cell-cell signaling; unfolded protein response; cell maturation; intracellular distribution of mitochondria; calcium-mediated signaling; positive regulation of transcription from RNA polymerase II promoter; glucose homeostasis; Golgi organization and biogenesis; mitochondrial calcium ion transport
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 Research Articles on BHLHA15    1. noted a higher mean value of microvascular density in CK5/6 and Ep-CAM-immunopositive tumors, carcinomas with aberrant CK8/18 expression, and carcinomas with no or strong expression of MMP-2 in stromal fibroblast-like cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-BHLHA15 antibodyDiseases associated with anti-BHLHA15 antibody
 Products by Pathway  Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
 Disease Name  Pubmed Publications
 Pancreatitis Antibodies  >1 publications with BHLHA15 and Pancreatitis
 Disease Models, Animal Antibodies  >1 publications with BHLHA15 and Disease Models, Animal
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