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anti-BICC1 antibody :: Rabbit BICC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9204871
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BICC1, Polyclonal Antibody

★Popular Item★
 Also Known As   

BICC1 Antibody (N-term)

 Product Synonym Names    Protein bicaudal C homolog 1; Bic-C; BICC1
 Product Gene Name   

anti-BICC1 antibody

[Similar Products]
 Antibody/Peptide Pairs    BICC1 peptide (MBS9226460) is used for blocking the activity of BICC1 antibody (MBS9204871)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    80-107
 OMIM    601331
 3D Structure    ModBase 3D Structure for Q9H694
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human (Predicted Reactivity: Xenopus, Mouse)
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 Specificity    This BICC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-107 amino acids from the N-terminal region of human BICC1.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Cellular Location    Cytoplasm
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-BICC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BICC1 antibody

   BICC1 is an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product.
Function: Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.
 Applications Tested/Suitable for anti-BICC1 antibody   

Western Blot (WB), Immunohistochemistry Parfaffin(IHC-P)

 Application Notes for anti-BICC1 antibody    WB~~1:1000
IHC-P ~~1:10~50
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 Western Blot (WB) of anti-BICC1 antibody    Western blot analysis of BICC1 Antibody (N-term) in HL-60 cell line lysates (35ug/lane). BICC1 (arrow) was detected using the purified Pab.
anti-BICC1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-BICC1 antibody    Formalin-fixed and paraffin-embedded human brain tissue reacted with BICC1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-BICC1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for BICC1. It may not necessarily be applicable to this product.
 NCBI GI #    122937472
 NCBI GeneID    80114
 NCBI Accession #    NP_001073981.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001080512.2 [Other Products]
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 UniProt Primary Accession #    Q9H694 [Other Products]
 UniProt Related Accession #    Q9H694 [Other Products]
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 NCBI Official Full Name    protein bicaudal C homolog 1
 NCBI Official Synonym Full Names    BicC family RNA binding protein 1
 NCBI Official Symbol    BICC1 [Similar Products]
 NCBI Official Synonym Symbols   
BICC; CYSRD
[Similar Products]
 NCBI Protein Information    protein bicaudal C homolog 1
 UniProt Protein Name    Protein bicaudal C homolog 1
 Protein Family    Protein bicaudal
 UniProt Gene Name    BICC1 [Similar Products]
 UniProt Synonym Gene Names    Bic-C [Similar Products]
 UniProt Entry Name    BICC1_HUMAN
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 NCBI Summary for BICC1    This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. [provided by RefSeq, Apr 2009]
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 UniProt Comments for BICC1    BICC1: Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. Defects in BICC1 are a cause of susceptibility to renal dysplasia, cystic (CYSRD). An anomaly of the kidney characterized by numerous renal cysts and apparent disorder of differentiation of the renal parenchyma. Kidney of affected individuals lack the normal renal bean shape, and the collection drainage system. The cystic, dysplastic kidney contains undifferentiated mesenchyme, cartilaginous tissue, and immature collecting ducts. Belongs to the BicC family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 10q21.1

Cellular Component: cytoplasm

Biological Process: multicellular organismal development

Disease: Renal Dysplasia, Cystic, Susceptibility To
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Product References and Citations for anti-BICC1 antibody

   Grupe,A., et.al., Am. J. Hum. Genet. 78 (1), 78-88 (2006)
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 Research Articles on BICC1    1. identify Bicc1 as a genetic determinant of osteoblastogenesis and BMD and suggest that it does so by regulating Pkd2 transcript levels
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BICC1 antibodyDiseases associated with anti-BICC1 antibody
 Reference Product  PubMed Publications
 PKD1 antibody  >2 publications with BICC1 and PKD1
 QKI antibody  >1 publications with BICC1 and QKI
 CPEB1 antibody  >1 publications with BICC1 and CPEB1
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >9 publications with BICC1 and Kidney Diseases
 Depressive Disorder Antibodies  >3 publications with BICC1 and Depressive Disorder
 Hypertension Antibodies  >2 publications with BICC1 and Hypertension
 Liver Neoplasms Antibodies  >2 publications with BICC1 and Liver Neoplasms
 Disease Models, Animal Antibodies  >2 publications with BICC1 and Disease Models, Animal
 Liver Diseases Antibodies  >2 publications with BICC1 and Liver Diseases
 Vascular Diseases Antibodies  >1 publications with BICC1 and Vascular Diseases
 Renal Insufficiency Antibodies  >1 publications with BICC1 and Renal Insufficiency
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with BICC1 and Drug-Related Side Effects and Adverse Reactions
 Carcinoma, Hepatocellular Antibodies  >1 publications with BICC1 and Carcinoma, Hepatocellular
Organs/Tissues associated with anti-BICC1 antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >16 publications with BICC1 and Kidney
 Liver Antibodies  >3 publications with BICC1 and Liver
 Brain Antibodies  >2 publications with BICC1 and Brain
 Bone Antibodies  >2 publications with BICC1 and Bone
 Muscle Antibodies  >1 publications with BICC1 and Muscle
 Embryonic Tissue Antibodies  >1 publications with BICC1 and Embryonic Tissue
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