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anti-SH3GLB1 antibody :: Goat BIF-1/SH3GLB1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420183
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BIF-1/SH3GLB1, Polyclonal Antibody

 Also Known As   

Goat anti-BIF-1/SH3GLB1 Antibody

 Product Synonym Names    SH3GLB1; Bif-1; SH3-domain GRB2-like endophilin B1; CGI-61; KIAA0491; endophilin B1; Bax-interacting factor 1; SH3-containing protein SH3GLB1; SH3-domain, GRB2-like, endophilin B1; SH3-containing protein SH3GLB1 CGI-61 protein endophilin B1; dJ612B15.2; SH3GLB1 antibody; Bif-1 antibody; SH3-domain GRB2-like endophilin B1 antibody; CGI-61 antibody; KIAA0491 antibody; endophilin B1 antibody; Bax-interacting factor 1 antibody; SH3-containing protein SH3GLB1 antibody; SH3-domain; GRB2-like; endophilin B1 antibody; SH3-containing protein SH3GLB1 CGI-61 protein endophilin B1 antibody; dJ612B15.2 antibody; BIF-1 / SH3GLB1
 Product Gene Name   

anti-SH3GLB1 antibody

[Similar Products]
 Product Synonym Gene Name    BIF-1 [Similar Products]
 Antibody/Peptide Pairs    BIF-1 / SH3GLB1 peptide (MBS425162) is used for blocking the activity of BIF-1/SH3GLB1 antibody (MBS420183)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QKGKVPITYL ELLN
 OMIM    609287
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QKGKVPITYLELLN, from the C Terminus of the protein sequence according to NP_057093.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SH3GLB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SH3GLB1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-SH3GLB1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 38kDa band observed in lysates of Human T cell line Jurkat and in Human Lung and Placenta (calculated MW of 40.8kDa according to NP_057093.1). Recommended concentration: 0.3-1. 0 ug/ml. A minor band of unknown identity was also consistently observed at 50kDa in Jurkat and Placenta. This band was successfully blocked by incubation with the immunising peptide.
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 Western Blot (WB) of anti-SH3GLB1 antibody    Staining (0.3ug/ml) of Jurkat lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-SH3GLB1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SH3GLB1. It may not necessarily be applicable to this product.
 NCBI GI #    7705773
 NCBI GeneID    51100
 NCBI Accession #    NP_057093.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_016009.4 [Other Products]
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 UniProt Secondary Accession #    Q5H8U5; Q9H3Z0; Q9NR47; Q9NYA9; B4E182 [Other Products]
 UniProt Related Accession #    Q9Y371 [Other Products]
 Molecular Weight    29,318 Da
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 NCBI Official Full Name    endophilin-B1 isoform 1
 NCBI Official Synonym Full Names    SH3 domain containing GRB2 like endophilin B1
 NCBI Official Symbol    SH3GLB1 [Similar Products]
 NCBI Official Synonym Symbols   
Bif-1; CGI-61; PPP1R70; dJ612B15.2
[Similar Products]
 NCBI Protein Information    endophilin-B1
 UniProt Protein Name    Endophilin-B1
 UniProt Synonym Protein Names   
Bax-interacting factor 1; Bif-1; SH3 domain-containing GRB2-like protein B1
 Protein Family    Endophilin
 UniProt Gene Name    SH3GLB1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0491; Bif-1 [Similar Products]
 UniProt Entry Name    SHLB1_HUMAN
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 NCBI Summary for SH3GLB1    This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
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 UniProt Comments for SH3GLB1    SH3GLB1: May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1. Homodimer, and heterodimer with SH3GLB2. Binds BAX. Induction of apoptosis augments BAX binding. Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes. Belongs to the endophilin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy; Mitochondrial; Transferase; EC 2.3.1.-; Apoptosis

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: cytoplasm; cytoplasmic vesicle; Golgi membrane; midbody; mitochondrial outer membrane

Molecular Function: identical protein binding; lipid binding; protein binding; protein homodimerization activity

Biological Process: apoptosis; autophagic cell death; autophagy; cellular response to amino acid starvation; cellular response to glucose starvation; positive regulation of autophagy; positive regulation of protein oligomerization; protein oligomerization; receptor catabolic process; regulation of cytokinesis; regulation of macroautophagy; regulation of protein stability
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 Research Articles on SH3GLB1    1. these data reveal an Irgm1-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SH3GLB1 antibodyDiseases associated with anti-SH3GLB1 antibody
 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >7 publications with SH3GLB1 and Adenocarcinoma
 Disease Models, Animal Antibodies  >3 publications with SH3GLB1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >2 publications with SH3GLB1 and Nervous System Diseases
 Urinary Bladder Neoplasms Antibodies  >1 publications with SH3GLB1 and Urinary Bladder Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with SH3GLB1 and Cell Transformation, Neoplastic
 Fibrosis Antibodies  >1 publications with SH3GLB1 and Fibrosis
 Inflammation Antibodies  >1 publications with SH3GLB1 and Inflammation
 Hyperplasia Antibodies  >1 publications with SH3GLB1 and Hyperplasia
 Necrosis Antibodies  >1 publications with SH3GLB1 and Necrosis
Organs/Tissues associated with anti-SH3GLB1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with SH3GLB1 and Blood
 Brain Antibodies  >3 publications with SH3GLB1 and Brain
 Stomach Antibodies  >2 publications with SH3GLB1 and Stomach
 Prostate Antibodies  >2 publications with SH3GLB1 and Prostate
 Muscle Antibodies  >2 publications with SH3GLB1 and Muscle
 Pancreas Antibodies  >2 publications with SH3GLB1 and Pancreas
 Lung Antibodies  >2 publications with SH3GLB1 and Lung
 Lymph Antibodies  >1 publications with SH3GLB1 and Lymph
 Kidney Antibodies  >1 publications with SH3GLB1 and Kidney
 Liver Antibodies  >1 publications with SH3GLB1 and Liver
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