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anti-BIRC2 antibody :: Rabbit BIRC2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7052793
Western Blot (WB)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BIRC2, Polyclonal Antibody

★Popular Item★
 Also Known As   

BIRC2 Antibody

 Product Synonym Names    Baculoviral IAP repeat-containing protein 2; Cellular inhibitor of apoptosis 1; C-IAP1; BIRC2; API1; MIHB; RNF48
 Product Gene Name   

anti-BIRC2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    L49431 mRNA
 3D Structure    ModBase 3D Structure for Q13490
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Baculoviral IAP repeat-containing protein 2 protein (1-300AA)
 Conjugation    Non-conjugated
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-BIRC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BIRC2 antibody

   Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.
 Applications Tested/Suitable for anti-BIRC2 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-BIRC2 antibody    WB: 1:500-1:5000
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 Western Blot (WB) of anti-BIRC2 antibody    Western Blot
Positive WB detected in: Rat liver tissue,Rat skeletal muscle tissue,Mouse heart tissue,Mouse lung tissue,Mouse brain tissue
All lanes: BIRC2 antibody at 3.5ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 70,65 KDa
Observed band size: 70,65 KDa

anti-BIRC2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for BIRC2. It may not necessarily be applicable to this product.
 NCBI GI #    4502141
 NCBI GeneID    329
 NCBI Accession #    NP_001157.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001166.4 [Other Products]
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 UniProt Primary Accession #    Q13490 [Other Products]
 UniProt Secondary Accession #    Q16516; Q4TTG0; B4E026 [Other Products]
 UniProt Related Accession #    Q13490 [Other Products]
 Molecular Weight    64,098 Da
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 NCBI Official Full Name    baculoviral IAP repeat-containing protein 2 isoform 1
 NCBI Official Synonym Full Names    baculoviral IAP repeat containing 2
 NCBI Official Symbol    BIRC2 [Similar Products]
 NCBI Official Synonym Symbols   
API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1
[Similar Products]
 NCBI Protein Information    baculoviral IAP repeat-containing protein 2
 UniProt Protein Name    Baculoviral IAP repeat-containing protein 2
 UniProt Synonym Protein Names   
Cellular inhibitor of apoptosis 1; C-IAP1
 Protein Family    Baculoviral IAP repeat-containing protein
 UniProt Gene Name    BIRC2 [Similar Products]
 UniProt Synonym Gene Names    API1; MIHB; RNF48; hIAP-2; hIAP2 [Similar Products]
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 NCBI Summary for BIRC2    The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for BIRC2    cIAP1: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO and MXD1/MAD1. Can also function as an E3 ubiquitin- protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. Interacts with CASP9. Interacts (via BIR domains) with TRAF2. Interacts with E2F1, RIPK1, RIPK2, RIPK3, RIPK4, BIRC5/survivin and USP19. Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes. The CARD domain inhibits the activation of E3 ubiquitin ligase activity by preventing RING domain dimerization and E2 ubiquitin donor binding and activation. The CARD domain- mediated autoinhibition of the E3 ubiquitin-protein ligase activity suppresses cell proliferation and migration. USP19 regulates the stability of BIRC2/c-IAP1 by preventing its ubiquitination. Belongs to the IAP family.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 11q22.2

Cellular Component: cytoplasm; cytosol; internal side of plasma membrane; nucleus; spindle microtubule

Molecular Function: caspase inhibitor activity; chaperone binding; protein binding; protein N-terminus binding; transcription coactivator activity; transferase activity; ubiquitin binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: cell structure disassembly during apoptosis; cell surface receptor linked signal transduction; I-kappaB kinase/NF-kappaB cascade; negative regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of apoptosis; regulation of cell cycle; regulation of cell differentiation; regulation of cell proliferation; regulation of inflammatory response; regulation of innate immune response; regulation of toll-like receptor signaling pathway; tumor necrosis factor-mediated signaling pathway
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 Research Articles on BIRC2    1. cIAP1 and cIAP2 mediate BCL10 ubiquitination essential for BCR-dependent NF-kB activity in the ABC subtype of DLBCL. cIAP1/2 attach K63-linked polyubiquitin chains on themselves and on BCL10, recruiting IKK and LUBAC essential for IKK activation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BIRC2 antibodyPathways associated with anti-BIRC2 antibody
 Reference Product  PubMed Publications
 CASP3 antibody  >29 publications with BIRC2 and CASP3
 TRAF2 antibody  >21 publications with BIRC2 and TRAF2
 CASP8 antibody  >16 publications with BIRC2 and CASP8
 DIABLO antibody  >14 publications with BIRC2 and DIABLO
 TRAF1 antibody  >12 publications with BIRC2 and TRAF1
 CASP7 antibody  >5 publications with BIRC2 and CASP7
 RIPK1 antibody  >3 publications with BIRC2 and RIPK1
 TNFRSF1A antibody  >2 publications with BIRC2 and TNFRSF1A
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
Diseases associated with anti-BIRC2 antibodyOrgans/Tissues associated with anti-BIRC2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >64 publications with BIRC2 and Neoplasms
 Necrosis Antibodies  >43 publications with BIRC2 and Necrosis
 Carcinoma Antibodies  >16 publications with BIRC2 and Carcinoma
 Leukemia Antibodies  >15 publications with BIRC2 and Leukemia
 Carcinoma, Squamous Cell Antibodies  >10 publications with BIRC2 and Carcinoma, Squamous Cell
 Inflammation Antibodies  >9 publications with BIRC2 and Inflammation
 Nervous System Diseases Antibodies  >7 publications with BIRC2 and Nervous System Diseases
 Melanoma Antibodies  >4 publications with BIRC2 and Melanoma
 Adenocarcinoma Antibodies  >4 publications with BIRC2 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >4 publications with BIRC2 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >20 publications with BIRC2 and Blood
 Vascular Antibodies  >9 publications with BIRC2 and Vascular
 Lung Antibodies  >8 publications with BIRC2 and Lung
 Brain Antibodies  >8 publications with BIRC2 and Brain
 Prostate Antibodies  >5 publications with BIRC2 and Prostate
 Intestine Antibodies  >5 publications with BIRC2 and Intestine
 Testis Antibodies  >5 publications with BIRC2 and Testis
 Kidney Antibodies  >4 publications with BIRC2 and Kidney
 Liver Antibodies  >3 publications with BIRC2 and Liver
 Eye Antibodies  >3 publications with BIRC2 and Eye
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