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anti-BMP4 antibody :: Rabbit anti-Human BMP4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241004
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BMP4, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human BMP4

 Product Synonym Names    Anti-BMP4 Antibody (aa20-34) IHC-plus; BMP4; BMP-2B; BMP-4; BMP2B; BMP2B1; Bone morphogenetic protein 2B; Bone morphogenetic protein 4; DVR4; MCOPS6; OFC11; Zyme; Human BMP4
 Product Gene Name   

anti-BMP4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 607932
 3D Structure    ModBase 3D Structure for P12644
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Amino acids 20 to 34 of human BMP4
 Purity/Purification    Protein G Purified
 Form/Format    PBS, 0.09% sodium azide
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human BMP4.
 Immunogen Type    Synthetic peptide
 Immunogen    BMP4 antibody was raised against synthetic peptide from human BMP4.
 Antigen Modification    aa20-34
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-BMP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BMP4 antibody

   Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Through molecular cloning, 7 BMP cDNAs, designated BMP1 through BMP7, have been recovered. BMP2 through BMP7, are members of the transforming growth factor-beta superfamily of regulatory molecules. Transcript variants utilizing alternative promoters and alternative non-coding first exons have been described in the literature.
 Product Categories/Family for anti-BMP4 antibody    Family: TGF beta
 Applications Tested/Suitable for anti-BMP4 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-BMP4 antibody    ELISA (1:000 - 1:1000), IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-BMP4 antibody    Anti-BMP4 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-BMP4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for BMP4. It may not necessarily be applicable to this product.
 NCBI GI #    157276593
 NCBI GeneID    652
 NCBI Accession #    NP_001193.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001202.3 [Other Products]
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 UniProt Primary Accession #    P12644 [Other Products]
 UniProt Secondary Accession #    Q9UM80 [Other Products]
 UniProt Related Accession #    P12644 [Other Products]
 Molecular Weight    46,555 Da
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 NCBI Official Full Name    bone morphogenetic protein 4 preproprotein
 NCBI Official Synonym Full Names    bone morphogenetic protein 4
 NCBI Official Symbol    BMP4 [Similar Products]
 NCBI Official Synonym Symbols   
ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
[Similar Products]
 NCBI Protein Information    bone morphogenetic protein 4; BMP-4; BMP-2B; bone morphogenetic protein 2B
 UniProt Protein Name    Bone morphogenetic protein 4
 UniProt Synonym Protein Names   
Bone morphogenetic protein 2B; BMP-2B
 Protein Family    Bone morphogenetic protein
 UniProt Gene Name    BMP4 [Similar Products]
 UniProt Synonym Gene Names    BMP2B; DVR4; BMP-4; BMP-2B [Similar Products]
 UniProt Entry Name    BMP4_HUMAN
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 NCBI Summary for BMP4    The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BMP4    BMP4: Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Homodimer; disulfide-linked. Interacts with GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition. Interacts with SOSTDC1. Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 14q22-q23

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: heparin binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding; chemoattractant activity

Biological Process: negative regulation of MAP kinase activity; extracellular matrix organization and biogenesis; renal system process; macrophage differentiation; activation of MAPKK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; lymphoid progenitor cell differentiation; telencephalon regionalization; germ cell development; post-embryonic development; regulation of protein import into nucleus; BMP signaling pathway; positive regulation of endothelial cell differentiation; positive chemotaxis; erythrocyte differentiation; chondrocyte differentiation; mesonephros development; kidney development; endochondral ossification; regulation of odontogenesis of dentine-containing teeth; negative regulation of immature T cell proliferation in the thymus; positive regulation of cardiac muscle fiber development; specification of organ position; monocyte differentiation; neuron fate commitment; embryonic cranial skeleton morphogenesis; negative regulation of striated muscle development; branching morphogenesis of a tube; negative regulation of mitosis; positive regulation of epidermal cell differentiation; negative regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; hemopoietic progenitor cell differentiation; steroid hormone mediated signaling; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; alveolus development; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; positive regulation of protein binding; positive regulation of smooth muscle cell proliferation; positive regulation of collagen biosynthetic process; cloacal septation; negative regulation of transcription from RNA polymerase II promoter; embryonic hindlimb morphogenesis; negative regulation of cell cycle; odontogenesis; smooth muscle development; negative regulation of cell proliferation; inner ear receptor cell differentiation; ureteric bud development; intermediate mesodermal cell differentiation; regulation of smooth muscle cell differentiation; dorsoventral neural tube patterning; positive regulation of BMP signaling pathway; negative regulation of epithelial cell proliferation; smoothened signaling pathway; common-partner SMAD protein phosphorylation; negative regulation of T cell differentiation in the thymus; positive regulation of bone mineralization; positive regulation of ossification; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of osteoblast differentiation; blood vessel endothelial cell proliferation during sprouting angiogenesis; telencephalon development; ureteric bud branching; pituitary gland development; neural tube closure; regulation of cell fate commitment; positive regulation of protein amino acid phosphorylation; negative regulation of myoblast differentiation; positive regulation of neuron differentiation; mesodermal cell fate determination; anterior/posterior axis specification

Disease: Orofacial Cleft 11; Microphthalmia, Syndromic 6
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 Research Articles on BMP4    1. the 6007C > T polymorphism of BMP-4 gene and BMP-4 tissue expression may be used as potential predictor for the chemotherapy response and prognosis of advanced nonsmall cell lung cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BMP4 antibodyPathways associated with anti-BMP4 antibody
 Reference Product  PubMed Publications
 SHH antibody  >247 publications with BMP4 and SHH
 BMPR2 antibody  >152 publications with BMP4 and BMPR2
 BMPR1A antibody  >150 publications with BMP4 and BMPR1A
 SMAD5 antibody  >83 publications with BMP4 and SMAD5
 BMPR1B antibody  >36 publications with BMP4 and BMPR1B
 NOG antibody  >21 publications with BMP4 and NOG
 SOSTDC1 antibody  >6 publications with BMP4 and SOSTDC1
 FST antibody  >4 publications with BMP4 and FST
 CHRD antibody  >4 publications with BMP4 and CHRD
 CHRDL1 antibody  >3 publications with BMP4 and CHRDL1
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glypican 3 Network Pathway antibodies  Glypican 3 Network Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
Diseases associated with anti-BMP4 antibodyOrgans/Tissues associated with anti-BMP4 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >111 publications with BMP4 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >108 publications with BMP4 and Disease Models, Animal
 Nervous System Diseases Antibodies  >105 publications with BMP4 and Nervous System Diseases
 Heart Diseases Antibodies  >68 publications with BMP4 and Heart Diseases
 Hypertension Antibodies  >64 publications with BMP4 and Hypertension
 Brain Diseases Antibodies  >60 publications with BMP4 and Brain Diseases
 Inflammation Antibodies  >57 publications with BMP4 and Inflammation
 Lung Diseases Antibodies  >53 publications with BMP4 and Lung Diseases
 Necrosis Antibodies  >45 publications with BMP4 and Necrosis
 Kidney Diseases Antibodies  >37 publications with BMP4 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2668 publications with BMP4 and Bone
 Embryonic Tissue Antibodies  >699 publications with BMP4 and Embryonic Tissue
 Brain Antibodies  >275 publications with BMP4 and Brain
 Vascular Antibodies  >253 publications with BMP4 and Vascular
 Heart Antibodies  >231 publications with BMP4 and Heart
 Mouth Antibodies  >179 publications with BMP4 and Mouth
 Connective Tissue Antibodies  >176 publications with BMP4 and Connective Tissue
 Eye Antibodies  >161 publications with BMP4 and Eye
 Lung Antibodies  >136 publications with BMP4 and Lung
 Skin Antibodies  >128 publications with BMP4 and Skin
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