NP_001195.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,963 Da
NCBI Official Full Name
bone morphogenetic protein receptor type-2
NCBI Official Synonym Full Names
bone morphogenetic protein receptor type 2
NCBI Official Synonym Symbols
BMR2; PPH1; BMPR3; BRK-3; POVD1; T-ALK; BMPR-II [Similar Products]
NCBI Protein Information
bone morphogenetic protein receptor type-2
UniProt Protein Name
Bone morphogenetic protein receptor type-2
UniProt Synonym Protein Names
Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II
UniProt Synonym Gene Names
PPH1; BMP type-2 receptor; BMPR-2; BMP type II receptor; BMPR-II [Similar Products]
NCBI Summary for BMPR2
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]
UniProt Comments for BMPR2
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Product References and Citations for anti-BMPR2 antibody
(1) Moller, T., Leren, T.P., Eiklid, K.L., et al. A novel BMPR2 gene mutation associated with exercise-induced pulmonary hypertension in septal defects. Scand. Cardiovasc. J. 44 (6), 331-336 (2010).
Research Articles on BMPR2
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Products associated with anti-BMPR2 antibody
Pathways associated with anti-BMPR2 antibody
Diseases associated with anti-BMPR2 antibody
Organs/Tissues associated with anti-BMPR2 antibody
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