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anti-BRCC3 antibody :: Rabbit BRCC3 / BRCC36 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241255
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BRCC3 / BRCC36, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal (IgG) to Human BRCC3 / BRCC36

 Product Synonym Names    Anti-BRCC3 / BRCC36 Antibody (N-Terminus) IHC-plus; BRCC3; C6.1A; BRCC36; BRISC complex subunit BRCC36; BRCA1-A complex subunit BRCC36; CXorf53; RP11-143H17.2; Human BRCC3; BRCC36
 Product Gene Name   

anti-BRCC3 antibody

[Similar Products]
 Product Synonym Gene Name    BRCC36 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    300617
 3D Structure    ModBase 3D Structure for P46736
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    An 18 amino acid peptide from near the amino terminus of humAn BRCC36
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    A 18 amino acid peptide from near the amino terminus of human BRCC36.
 Immunogen Type    Synthetic peptide
 Immunogen    BRCC3 / BRCC36 antibody was raised against a 18 amino acid peptide from near the amino terminus of human BRCC36.
 Antigen Modification    N-Terminus
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-BRCC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-BRCC3 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-BRCC3 antibody    IHC-P (5 ug/ml), WB (0.5 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-BRCC3 antibody    Anti-BRCC3 / BRCC36 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-BRCC3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-BRCC3 antibody    Anti-BRCC3 / BRCC36 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-BRCC3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-BRCC3 antibody    Immunofluorescence of BRCC36 in Human Brain cells with BRCC36 antibody at 20 ug/ml.
anti-BRCC3 antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-BRCC3 antibody    Western blot of BRCC36 in MCF7 cell lysate with BRCC36 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
anti-BRCC3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for BRCC3. It may not necessarily be applicable to this product.
 NCBI GI #    13236583
 NCBI GeneID    79184
 NCBI Accession #    NP_077308.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_024332.3 [Other Products]
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 UniProt Primary Accession #    P46736 [Other Products]
 UniProt Secondary Accession #    Q16107; Q53YX5; Q9BTZ6; A6QRF8; A6QRF9; A8MUX5; A8MWH0; A9Z1Y0; A9Z1Y5; B1B062; B4DQN7 [Other Products]
 UniProt Related Accession #    P46736 [Other Products]
 Molecular Weight    28,027 Da
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 NCBI Official Full Name    lys-63-specific deubiquitinase BRCC36 isoform 1
 NCBI Official Synonym Full Names    BRCA1/BRCA2-containing complex, subunit 3
 NCBI Official Symbol    BRCC3 [Similar Products]
 NCBI Official Synonym Symbols   
C6.1A; BRCC36; CXorf53
[Similar Products]
 NCBI Protein Information    lys-63-specific deubiquitinase BRCC36; BRISC complex subunit BRCC36; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 36
 UniProt Protein Name    Lys-63-specific deubiquitinase BRCC36
 UniProt Synonym Protein Names   
BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36
 Protein Family    Lys-63-specific deubiquitinase
 UniProt Gene Name    BRCC3 [Similar Products]
 UniProt Synonym Gene Names    BRCC36; C6.1A; CXorf53 [Similar Products]
 UniProt Entry Name    BRCC3_HUMAN
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 NCBI Summary for BRCC3    This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
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 UniProt Comments for BRCC3    BRCC3: Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'- specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. A chromosomal aberration involving BRCC3 is a cause of pro-lymphocytic T-cell leukemia (T-PLL). Translocation t(X;14)(q28;q11) with TCRA. Belongs to the peptidase M67A family. BRCC36 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; EC 3.4.19.-; Ubiquitin-specific protease; Oncoprotein

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: nucleoplasm; nuclear ubiquitin ligase complex; nucleus; ubiquitin ligase complex

Molecular Function: protein binding; metallopeptidase activity; metal ion binding; ubiquitin-specific protease activity; polyubiquitin binding; enzyme regulator activity

Biological Process: positive regulation of DNA repair; regulation of catalytic activity; double-strand break repair; response to ionizing radiation; proteolysis; G2/M transition DNA damage checkpoint; response to X-ray
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 Research Articles on BRCC3    1. these data strongly suggest that BRCC3, a deubiquitinating enzyme that is part of the cellular BRCA1 and BRISC complexes, is an important player in angiogenesis and that BRCC3 loss-of-function mutations are associated with moyamoya angiopathy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-BRCC3 antibodyOrgans/Tissues associated with anti-BRCC3 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >4 publications with BRCC3 and Breast Neoplasms
 Carcinoma Antibodies  >1 publications with BRCC3 and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with BRCC3 and Blood
 Kidney Antibodies  >2 publications with BRCC3 and Kidney
 Heart Antibodies  >1 publications with BRCC3 and Heart
 Mammary Gland Antibodies  >1 publications with BRCC3 and Mammary Gland
 Brain Antibodies  >1 publications with BRCC3 and Brain
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