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anti-BTRC antibody :: Rabbit anti-Human BTRC Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7051680
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BTRC, Polyclonal Antibody

★Popular Item★
 Also Known As   

BTRC Antibody

 Product Synonym Names    F-box/WD repeat-containing protein 1A; E3RSIkappaB; Epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; pIkappaBalpha-E3 receptor subuni; BTRC; BTRCP; FBW1A; FBXW1A
 Product Gene Name   

anti-BTRC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF101784 mRNA
 3D Structure    ModBase 3D Structure for Q9Y297
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human F-box/WD repeat-containing protein 1A protein (397-448AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-15354 / sc-33213 / sc-8862 / sc-8863
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-BTRC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-BTRC antibody

   Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed: 25704143, PubMed: 25503564). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.
 Applications Tested/Suitable for anti-BTRC antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-BTRC antibody    WB: 1: 2000-1: 10000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-BTRC antibody    Western Blot
Positive WB detected in:K562 whole cell lysate
All lanes: BTRC antibody at 2.8ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 69,66 kDa
Observed band size: 69 kDa

anti-BTRC antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-BTRC antibody    Immunohistochemistry of paraffin-embedded human pancreatic tissue using MBS7051680 at dilution of 1:100
anti-BTRC antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-BTRC antibody    Immunofluorescent analysis of HepG2 cells using MBS7051680 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-BTRC antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for BTRC. It may not necessarily be applicable to this product.
 NCBI GI #    4502477
 NCBI GeneID    8945
 NCBI Accession #    NP_003930.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003939.4 [Other Products]
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 UniProt Primary Accession #    Q9Y297 [Other Products]
 UniProt Secondary Accession #    Q5W141; Q5W142; Q9Y213; B5MD49 [Other Products]
 UniProt Related Accession #    Q9Y297 [Other Products]
 Molecular Weight    65,049 Da
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 NCBI Official Full Name    F-box/WD repeat-containing protein 1A isoform 2
 NCBI Official Synonym Full Names    beta-transducin repeat containing E3 ubiquitin protein ligase
 NCBI Official Symbol    BTRC [Similar Products]
 NCBI Official Synonym Symbols   
FWD1; FBW1A; FBXW1; bTrCP; FBXW1A; bTrCP1; betaTrCP; BETA-TRCP
[Similar Products]
 NCBI Protein Information    F-box/WD repeat-containing protein 1A
 UniProt Protein Name    F-box/WD repeat-containing protein 1A
 UniProt Synonym Protein Names   
E3RSIkappaB; Epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; pIkappaBalpha-E3 receptor subunit
 Protein Family    F-box/WD repeat-containing protein
 UniProt Gene Name    BTRC [Similar Products]
 UniProt Synonym Gene Names    BTRCP; FBW1A; FBXW1A [Similar Products]
 UniProt Entry Name    FBW1A_HUMAN
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 NCBI Summary for BTRC    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
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 UniProt Comments for BTRC    BTRC: a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Regulates the stability of CTNNB1 and participates in Wnt signaling. Interacts directly with SKP1 in the SCF complex. Interacts specifically with phosphorylated CTNNB1 and NFKBIA, ubiquitination substrates. Two alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 10q24.32

Cellular Component: cytosol; nucleoplasm; SCF ubiquitin ligase complex

Molecular Function: beta-catenin binding; protein binding; ubiquitin-protein ligase activity

Biological Process: G2/M transition of mitotic cell cycle; negative regulation of smoothened signaling pathway; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of circadian rhythm; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid dephosphorylation; protein destabilization; protein polyubiquitination; protein ubiquitination; regulation of circadian rhythm; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; signal transduction; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway
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 Research Articles on BTRC    1. Phosphorylated VEGFR-2 was reduced by hyperglycemia while total VEGFR-2 was almost unaltered. However, VEGFR-2 was reduced when directly exposed to reactive oxygen species, with resultant co-location of beta-TrCP and VEGFR-2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BTRC antibodyPathways associated with anti-BTRC antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >41 publications with BTRC and CTNNB1
 SKP1 antibody  >25 publications with BTRC and SKP1
 NFKBIA antibody  >16 publications with BTRC and NFKBIA
 CUL1 antibody  >12 publications with BTRC and CUL1
 NFKB2 antibody  >2 publications with BTRC and NFKB2
 CDC25A antibody  >2 publications with BTRC and CDC25A
 PER1 antibody  >1 publications with BTRC and PER1
 PER2 antibody  >1 publications with BTRC and PER2
 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alternative NF-kappaB Pathway antibodies  Alternative NF-kappaB Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Atypical NF-kappaB Pathway antibodies  Atypical NF-kappaB Pathway Diagram
 C-type Lectin Receptors (CLRs) Pathway antibodies  C-type Lectin Receptors (CLRs) Pathway Diagram
 CLEC7A (Dectin-1) Signaling Pathway antibodies  CLEC7A (Dectin-1) Signaling Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
Diseases associated with anti-BTRC antibodyOrgans/Tissues associated with anti-BTRC antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >12 publications with BTRC and Necrosis
 Adenocarcinoma Antibodies  >9 publications with BTRC and Adenocarcinoma
 Nervous System Diseases Antibodies  >8 publications with BTRC and Nervous System Diseases
 Inflammation Antibodies  >8 publications with BTRC and Inflammation
 Cell Transformation, Neoplastic Antibodies  >7 publications with BTRC and Cell Transformation, Neoplastic
 Congenital Abnormalities Antibodies  >7 publications with BTRC and Congenital Abnormalities
 Central Nervous System Diseases Antibodies  >7 publications with BTRC and Central Nervous System Diseases
 Liver Neoplasms Antibodies  >6 publications with BTRC and Liver Neoplasms
 Lung Neoplasms Antibodies  >4 publications with BTRC and Lung Neoplasms
 Uterine Cervical Neoplasms Antibodies  >3 publications with BTRC and Uterine Cervical Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with BTRC and Brain
 Blood Antibodies  >8 publications with BTRC and Blood
 Lung Antibodies  >6 publications with BTRC and Lung
 Vascular Antibodies  >6 publications with BTRC and Vascular
 Muscle Antibodies  >4 publications with BTRC and Muscle
 Skin Antibodies  >4 publications with BTRC and Skin
 Bone Antibodies  >3 publications with BTRC and Bone
 Heart Antibodies  >3 publications with BTRC and Heart
 Kidney Antibodies  >2 publications with BTRC and Kidney
 Eye Antibodies  >2 publications with BTRC and Eye
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