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anti-BCL11A antibody :: Rabbit anti-Human Bcl 11a Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS615024 anti-BCL11A antibody
Unit / Price
0.1 mL  /  $765 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bcl 11a (BCL11A), Polyclonal Antibody

 Also Known As   

Bcl 11a (B-cell CLL/Lymphoma 11A, EVI9, Ecotropic Viral Integration Site 9, CTIP1, CTIP-1, COUP-TF Interacting Protein 1)

 Product Synonym Names    Anti -Bcl 11a (B-cell CLL/Lymphoma 11A, EVI9, Ecotropic Viral Integration Site 9, CTIP1, CTIP-1, COUP-TF Interacting Protein 1)
 Product Gene Name   

anti-BCL11A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (60678302..60780633, complement). Location: 2p16.1
 OMIM    142335
 3D Structure    ModBase 3D Structure for Q9H165
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Specific for human Bcl-11a protein. Species Crossreactivity: Human. Other species not tested. Reactivity with mouse Bcl11a is expected owing to complete identity between this ortholog and human Bcl11a at the site to which the epitope maps.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
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 Immunogen    A synthetic peptide which maps to a region between residues 775 and the C-terminus (residue 835) of human B-cell CLL/Lymphoma 11A using the numbering given in Swiss-Prot entry Q9H165 (GeneID 53335).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-BCL11A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-BCL11A antibody

   The B cell leukemia 11A protein (BCL11A/Evi9/CTIP1) has been implicated in hematopoietic cell development and malignancies. BCL11A is a transcriptional repressor that binds directly to a GC-rich motif and is also recruited to a promoter template via interaction with the orphan nuclear receptor, chicken ovalbumin upstream promoter transcription factor II. In both cases, BCL11A-mediated transcriptional repression is only minimally reversed by trichostatin A, suggesting the possible lack of involvement of class I or II histone deacetylases. Nonetheless, chromatin immunoprecipitation assays revealed that expression of BCL11A in mammalian cells resulted in deacetylation of histones H3 and/or H4 that were associated with the promoter region of a reporter gene. BCL11A mediated transcriptional repression, as well as deacetylation of histone H3/H4 in BCL11A-transfected cells, was partially reversed by nicotinamide, an inhibitor of class III histone deacetylases such as SIRT1. SIRT1 was found to interact directly with BCL11A and was recruited to the promoter template in a BCL11A-dependent manner leading to transcriptional repression. These findings indicate a role for SIRT1 in transcriptional repression mediated by BCL11A in mammalian cells.
 Product Categories/Family for anti-BCL11A antibody    Antibodies; Abs to Apoptosis
 Applications Tested/Suitable for anti-BCL11A antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-BCL11A antibody    Suitable for use in Western Blot and Immunoprecipitation.
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NCBI/Uniprot data below describe general gene information for BCL11A. It may not necessarily be applicable to this product.
 NCBI GI #    20336305
 NCBI GeneID    53335
 NCBI Accession #    NP_075044.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_022893.3 [Other Products]
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 UniProt Primary Accession #    Q9H165 [Other Products]
 UniProt Secondary Accession #    Q86W14; Q8WU92; Q96JL6; Q9H163; Q9H164; Q9H3G9; Q9NWA7; D6W5D7 [Other Products]
 UniProt Related Accession #    Q53TE8; Q53TS1; Q66LN6; Q9H165 [Other Products]
 Molecular Weight    91,197 Da [Similar Products]
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 NCBI Official Full Name    B-cell lymphoma/leukemia 11A isoform 1
 NCBI Official Synonym Full Names    B-cell CLL/lymphoma 11A (zinc finger protein)
 NCBI Official Symbol    BCL11A [Similar Products]
 NCBI Official Synonym Symbols   
EVI9; CTIP1; ZNF856; HBFQTL5; BCL11A-L; BCL11A-S; FLJ10173; FLJ34997; KIAA1809; BCL11A-XL
[Similar Products]
 NCBI Protein Information    B-cell lymphoma/leukemia 11A; EVI-9; BCL-11A; OTTHUMP00000159788; OTTHUMP00000159789; OTTHUMP00000201250; OTTHUMP00000202084; zinc finger protein 856; C2H2-type zinc finger protein; COUP-TF-interacting protein 1; ecotropic viral integration site 9 homolog; ecotropic viral integration site 9 protein homolog; B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2; BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1
 UniProt Protein Name    B-cell lymphoma/leukemia 11A
 UniProt Synonym Protein Names   
B-cell CLL/lymphoma 11A; COUP-TF-interacting protein 1; Ecotropic viral integration site 9 protein homolog; EVI-9; Zinc finger protein 856
 Protein Family    B-cell lymphoma/leukemia
 UniProt Gene Name    BCL11A [Similar Products]
 UniProt Synonym Gene Names    CTIP1; EVI9; KIAA1809; ZNF856 [Similar Products]
 UniProt Entry Name    BC11A_HUMAN
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 NCBI Summary for BCL11A    This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for BCL11A    Bcl-11A: Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and amplification. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 2p16.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein homodimerization activity; protein heterodimerization activity; metal ion binding; transcription corepressor activity

Biological Process: protein sumoylation; transcription, DNA-dependent; B cell differentiation; regulation of dendrite development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of collateral sprouting; negative regulation of axon extension; negative regulation of transcription from RNA polymerase II promoter; positive regulation of collateral sprouting; negative regulation of protein homooligomerization; T cell differentiation
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 Research Articles on BCL11A    1. BCL11A is a potent silencer of fetal hemoglobin. It controls the beta-globin gene cluster in concert with other factors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-BCL11A antibodyOrgans/Tissues associated with anti-BCL11A antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >40 publications with BCL11A and Neoplasms
 Anemia Antibodies  >25 publications with BCL11A and Anemia
 Chromosome Aberrations Antibodies  >22 publications with BCL11A and Chromosome Aberrations
 Translocation, Genetic Antibodies  >12 publications with BCL11A and Translocation, Genetic
 Leukemia, Myeloid Antibodies  >7 publications with BCL11A and Leukemia, Myeloid
 Fetal Diseases Antibodies  >4 publications with BCL11A and Fetal Diseases
 Diabetes Mellitus, Type 2 Antibodies  >4 publications with BCL11A and Diabetes Mellitus, Type 2
 Leukemia, Myeloid, Acute Antibodies  >4 publications with BCL11A and Leukemia, Myeloid, Acute
 Skin Diseases Antibodies  >3 publications with BCL11A and Skin Diseases
 Carcinoma Antibodies  >3 publications with BCL11A and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >39 publications with BCL11A and Blood
 Brain Antibodies  >8 publications with BCL11A and Brain
 Heart Antibodies  >4 publications with BCL11A and Heart
 Thymus Antibodies  >3 publications with BCL11A and Thymus
 Embryonic Tissue Antibodies  >3 publications with BCL11A and Embryonic Tissue
 Lung Antibodies  >3 publications with BCL11A and Lung
 Lymph Node Antibodies  >3 publications with BCL11A and Lymph Node
 Pancreas Antibodies  >2 publications with BCL11A and Pancreas
 Lymph Antibodies  >2 publications with BCL11A and Lymph
 Skin Antibodies  >2 publications with BCL11A and Skin
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