AAK48715.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
BCLB
NCBI Official Synonym Full Names
BCL2-like 10 (apoptosis facilitator)
NCBI Protein Information
bcl-2-like protein 10
UniProt Protein Name
Bcl-2-like protein 10
UniProt Synonym Protein Names
Anti-apoptotic protein NrH; Apoptosis regulator Bcl-B
UniProt Synonym Gene Names
UniProt Entry Name
B2L10_HUMAN
NCBI Summary for BclB
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]
UniProt Comments for BclB
BCL2L10: Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1. Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. Belongs to the Bcl-2 family.
Protein type: Membrane protein, integral; Apoptosis
Chromosomal Location of Human Ortholog: 15q21
Cellular Component: mitochondrial outer membrane; nuclear membrane; membrane; mitochondrion; integral to membrane; cytosol
Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity
Biological Process: caspase activation; DNA damage response, signal transduction resulting in induction of apoptosis; female gamete generation; spermatogenesis; negative regulation of apoptosis
Research Articles on BclB
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Products associated with anti-BclB antibody
Pathways associated with anti-BclB antibody
Diseases associated with anti-BclB antibody
Organs/Tissues associated with anti-BclB antibody
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