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anti-Bcr antibody :: Rabbit anti-Human, Mouse Bcr Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS857413
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bcr, Polyclonal Antibody

 Also Known As   

Bcr (Phospho-Tyr177) Antibody

 Product Gene Name   

anti-Bcr antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 608232
 3D Structure    ModBase 3D Structure for P11274
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Bcr (phospho-Tyr177) antibody detects endogenous levels of Bcr only when phosphorylated at tyrosine 177.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    50ug/50ul (lot specific)
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human Bcr around the phosphorylation site of tyrosine 177 (P-F-YP-V-N).
 Pathway    CellCycle, Kinase/Phosphatases
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-Bcr antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Bcr antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-Bcr antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-Bcr antibody    WB: 1:500~1:1000, IHC: 1:50~1:100
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 Testing Data of anti-Bcr antibody    P-Peptide - +
Immunohistochemical analysis of paraffin-embedded human tonsil tumor tissue, using Bcr (phospho-Tyr177) antibody (E011199).
anti-Bcr antibody Testing Data image
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 Testing Data #2 of anti-Bcr antibody    Western blot analysis of extract from A431 ce lls, untreated or treated with EGF (200ng/ml, 5min), using Bcr (Ab-177) antibody and Bcr(phospho-Tyr177) antibody (E011199, Lane 3 and 4).
anti-Bcr antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for Bcr. It may not necessarily be applicable to this product.
 NCBI GI #    82546843
 NCBI GeneID    613
 NCBI Accession #    NP_004318.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_004327.3 [Other Products]
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 UniProt Primary Accession #    P11274 [Other Products]
 UniProt Secondary Accession #    P78501; Q12842; Q4LE80; Q6NZI3 [Other Products]
 UniProt Related Accession #    P11274 [Other Products]
 Molecular Weight    137,729 Da
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 NCBI Official Full Name    breakpoint cluster region protein isoform 1
 NCBI Official Synonym Full Names    breakpoint cluster region
 NCBI Official Symbol    BCR [Similar Products]
 NCBI Official Synonym Symbols   
ALL; CML; PHL; BCR1; D22S11; D22S662
[Similar Products]
 NCBI Protein Information    breakpoint cluster region protein; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; renal carcinoma antigen NY-REN-26
 UniProt Protein Name    Breakpoint cluster region protein
 UniProt Synonym Protein Names   
Renal carcinoma antigen NY-REN-26
 Protein Family    Bicyclomycin resistance protein
 UniProt Gene Name    BCR [Similar Products]
 UniProt Synonym Gene Names    BCR1; D22S11 [Similar Products]
 UniProt Entry Name    BCR_HUMAN
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 NCBI Summary for Bcr    A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Bcr    Bcr: a protein with serine/threonine protein kinase activity and is a GTPase-activating protein (GAP) for RAC1 and CDC42. The amino-terminal region of Bcr contains an oligomerization domain, a serine/threonine kinase domain and a region that binds SH2 domains. The middle of the protein has a PH domain and a region of sequence similarity to the guanine nucleotide exchange factors for the Rho family of GTP binding proteins. The carboxy-terminal region promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. A breakpoint cluster region protein that participates in a t(9;22)(q34;q11) chromosomal translocation that produces a BCR-ABL oncogene responsible for chronic myeloid leukemia (CML), acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The function of wild type Bcr in cells remains unclear. PDGF receptor may use Bcr as a downstream signaling mediator. Tyr177 of human Bcr, phosphorylated in the Bcr-Abl fusion protein, provides a docking site for Gab2 and GRB2, and is important in the transforming activity of Bcr-Abl. Sequence variants of the Bcr protein may be associated with bipolar disorder. Two alternatively spliced isoforms of the human protein have been reported.

Protein type: EC 2.7.11.1; Oncoprotein; GEFs, Rac/Rho; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); GAPs, Rac/Rho; GAPs; Protein kinase, atypical; ATYPICAL group; BCR family

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: postsynaptic membrane; protein complex; membrane; postsynaptic density; cytosol; cell junction

Molecular Function: protein serine/threonine kinase activity; protein binding; Rho guanyl-nucleotide exchange factor activity; enzyme binding; protein-tyrosine kinase activity; kinase activity; ATP binding; GTPase activator activity

Biological Process: inner ear morphogenesis; peptidyl-tyrosine phosphorylation; regulation of cell cycle; protein amino acid autophosphorylation; response to lipopolysaccharide; platelet-derived growth factor receptor signaling pathway; signal transduction; protein amino acid phosphorylation; negative regulation of neutrophil degranulation; regulation of small GTPase mediated signal transduction; positive regulation of phagocytosis; small GTPase mediated signal transduction; negative regulation of inflammatory response; brain development; actin cytoskeleton organization and biogenesis; neuromuscular process controlling balance; negative regulation of cell migration

Disease: Leukemia, Acute Lymphoblastic; Leukemia, Chronic Myeloid
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Product References and Citations for anti-Bcr antibody

   Sattler M, et al. Mol Cell Biol. 1999 Nov; 19(11): 7473-7480.
Li S et al. EMBO J. 2001 Dec 3; 20(23): 6793-6804.
Million RP, et,al. Mol Cell Biol. 2004 Jun; 24(11): 4685-4695.
Malcolm A. Meyn, et al.. Biol. Chem., Oct 2006; 281: 30907 - 30916.
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 Research Articles on Bcr    1. Findings show that residual Ph(+) cells are low BCR-ABL1 producers, and that DNA-based methods are required to assess the content of persisting Ph(+) stem cells in these patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Bcr antibodyPathways associated with anti-Bcr antibody
 Reference Product  PubMed Publications
 ABL1 antibody  >802 publications with Bcr and ABL1
 CRKL antibody  >160 publications with Bcr and CRKL
 GRB2 antibody  >152 publications with Bcr and GRB2
 CBL antibody  >126 publications with Bcr and CBL
 PIK3CA antibody  >26 publications with Bcr and PIK3CA
 FES antibody  >24 publications with Bcr and FES
 VAV2 antibody  >10 publications with Bcr and VAV2
 SOS1 antibody  >7 publications with Bcr and SOS1
 ARHGDIA antibody  >3 publications with Bcr and ARHGDIA
 PIK3CG antibody  >3 publications with Bcr and PIK3CG
 Products by Pathway  Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Regulation Of RAC1 Activity Pathway antibodies  Regulation Of RAC1 Activity Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By FGFR In Disease Pathway antibodies  Signaling By FGFR In Disease Pathway Diagram
 Signaling By FGFR Mutants Pathway antibodies  Signaling By FGFR Mutants Pathway Diagram
Diseases associated with anti-Bcr antibodyOrgans/Tissues associated with anti-Bcr antibody
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >17928 publications with Bcr and Leukemia
 Myeloproliferative Disorders Antibodies  >14617 publications with Bcr and Myeloproliferative Disorders
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >14384 publications with Bcr and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Leukemia, Myeloid, Acute Antibodies  >3033 publications with Bcr and Leukemia, Myeloid, Acute
 Blast Crisis Antibodies  >2049 publications with Bcr and Blast Crisis
 Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >1874 publications with Bcr and Precursor Cell Lymphoblastic Leukemia-Lymphoma
 Breast Neoplasms Antibodies  >1853 publications with Bcr and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >590 publications with Bcr and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >574 publications with Bcr and Nervous System Diseases
 Anemia Antibodies  >565 publications with Bcr and Anemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8613 publications with Bcr and Blood
 Bone Antibodies  >5787 publications with Bcr and Bone
 Bone Marrow Antibodies  >5552 publications with Bcr and Bone Marrow
 Spleen Antibodies  >634 publications with Bcr and Spleen
 Lymph Node Antibodies  >513 publications with Bcr and Lymph Node
 Liver Antibodies  >479 publications with Bcr and Liver
 Prostate Antibodies  >441 publications with Bcr and Prostate
 Lymph Antibodies  >430 publications with Bcr and Lymph
 Lung Antibodies  >427 publications with Bcr and Lung
 Skin Antibodies  >413 publications with Bcr and Skin
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