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anti-BECN1 antibody :: Rabbit Beclin-1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151455
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Beclin-1 (BECN1), Polyclonal Antibody

 Also Known As   

Beclin-1 Antibody

 Product Synonym Names    Beclin-1; ATG6; VPS30; beclin1; GT197; Beclin-1; Coiled-coil myosin-like BCL2-interacting protein; beclin 1, autophagy related
 Product Gene Name   

anti-BECN1 antibody

[Similar Products]
 Antibody/Peptide Pairs    Beclin-1 peptide (MBS152086) is used for blocking the activity of Beclin-1 antibody (MBS151455)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604378
 3D Structure    ModBase 3D Structure for Q14457
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Beclin-1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    Beclin-1 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human Beclin-1.
 Buffer    Beclin-1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    Beclin-1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-BECN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-BECN1 antibody

   Beclin-1 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6, is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death.
 Applications Tested/Suitable for anti-BECN1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-BECN1 antibody    Beclin-1 antibody can be used for the detection of Beclin-1 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2 mug/mL.
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 Western Blot (WB) of anti-BECN1 antibody    Western blot analysis of Beclin-1 in 293 cell lysate with Beclin-1 antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.
anti-BECN1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-BECN1 antibody    Immunohistochemistry of beclin-1 in rat brain tissue with beclin-1 antibody at 2 μg/mL.
anti-BECN1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for BECN1. It may not necessarily be applicable to this product.
 NCBI GI #    16307457
 NCBI GeneID    8678
 NCBI Accession #    AAH10276 [Other Products]
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 UniProt Primary Accession #    Q14457 [Other Products]
 UniProt Secondary Accession #    O75595; Q9UNA8; B2R6N7 [Other Products]
 UniProt Related Accession #    Q14457 [Other Products]
 Molecular Weight    51,896 Da
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 NCBI Official Full Name    Beclin 1, autophagy related
 NCBI Official Synonym Full Names    beclin 1, autophagy related
 NCBI Official Symbol    BECN1 [Similar Products]
 NCBI Official Synonym Symbols   
ATG6; VPS30; beclin1
[Similar Products]
 NCBI Protein Information    beclin-1; ATG6 autophagy related 6 homolog; coiled-coil myosin-like BCL2-interacting protein; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
 UniProt Protein Name    Beclin-1
 UniProt Synonym Protein Names   
Coiled-coil myosin-like BCL2-interacting protein; Protein GT197
 Protein Family    Beclin
 UniProt Gene Name    BECN1 [Similar Products]
 UniProt Synonym Gene Names    GT197 [Similar Products]
 UniProt Entry Name    BECN1_HUMAN
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 NCBI Summary for BECN1    Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010]
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 UniProt Comments for BECN1    beclin 1: an essential autophagy protein that has been linked to multiple processes including tumor suppression, protection against some cardiac and neurological degenerative diseases, and lifespan extension. A ubiquitous protein of the beclin family. Is part of the class III PI3K complex that induces autophagy. Expressed at elevated levels in dendrites and cell bodies of cerebellar Purkinje cells. Interacts with the anti-apoptotic protein Bcl-2, which inhibits autophagy when it is present in the endoplasmic reticulum. The dissociation of ATG6 from Bcl-2 is essential for its autophagic activity. Interacts with PITC and GluR-delta2. Probably forms a complex with AMBRA1 and PIK3C3. Plays a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.

Protein type: Autophagy; Membrane protein, peripheral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: extrinsic to membrane; mitochondrion; endoplasmic reticulum; dendrite; cytoplasmic membrane-bound vesicle; phagocytic vesicle; trans-Golgi network; nucleus; endosome

Molecular Function: protein binding; phosphoinositide 3-kinase binding

Biological Process: response to drug; viral reproduction; late endosome to vacuole transport; cytokinesis; CVT pathway; cellular response to nitrogen starvation; negative regulation of cell proliferation; response to vitamin E; regulation of catalytic activity; lysosome organization and biogenesis; beta-amyloid metabolic process; mitochondrion degradation; response to hypoxia; neuron development; cellular defense response; defense response to virus; positive regulation of macroautophagy; positive regulation of autophagy; autophagic vacuole formation; negative regulation of apoptosis
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 Research Articles on BECN1    1. There was an inverse correlation between p62 and Beclin-1 levels in primary cells and MM cell lines.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BECN1 antibodyPathways associated with anti-BECN1 antibody
 Reference Product  PubMed Publications
 BCL2L1 antibody  >55 publications with BECN1 and BCL2L1
 BCL2 antibody  >48 publications with BECN1 and BCL2
 UVRAG antibody  >41 publications with BECN1 and UVRAG
 ATG14 antibody  >25 publications with BECN1 and ATG14
 AMBRA1 antibody  >21 publications with BECN1 and AMBRA1
 PIK3C3 antibody  >14 publications with BECN1 and PIK3C3
 DAPK1 antibody  >10 publications with BECN1 and DAPK1
 PIK3R4 antibody  >7 publications with BECN1 and PIK3R4
 Products by Pathway  Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
Diseases associated with anti-BECN1 antibodyOrgans/Tissues associated with anti-BECN1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >140 publications with BECN1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >88 publications with BECN1 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >82 publications with BECN1 and Adenocarcinoma
 Necrosis Antibodies  >78 publications with BECN1 and Necrosis
 Breast Neoplasms Antibodies  >70 publications with BECN1 and Breast Neoplasms
 Disease Models, Animal Antibodies  >70 publications with BECN1 and Disease Models, Animal
 Liver Diseases Antibodies  >51 publications with BECN1 and Liver Diseases
 Liver Neoplasms Antibodies  >44 publications with BECN1 and Liver Neoplasms
 Inflammation Antibodies  >43 publications with BECN1 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >42 publications with BECN1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >140 publications with BECN1 and Brain
 Blood Antibodies  >83 publications with BECN1 and Blood
 Liver Antibodies  >75 publications with BECN1 and Liver
 Muscle Antibodies  >72 publications with BECN1 and Muscle
 Heart Antibodies  >65 publications with BECN1 and Heart
 Lung Antibodies  >56 publications with BECN1 and Lung
 Vascular Antibodies  >47 publications with BECN1 and Vascular
 Nerve Antibodies  >37 publications with BECN1 and Nerve
 Kidney Antibodies  >33 publications with BECN1 and Kidney
 Prostate Antibodies  >27 publications with BECN1 and Prostate
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