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anti-ACTB antibody :: Rabbit Beta-actin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS821786
Unit / Price
0.03 mL  /  $135 +1 FREE 8GB USB
0.1 mL  /  $185 +1 FREE 8GB USB
0.2 mL  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Beta-actin (ACTB), Polyclonal Antibody

 Also Known As   

Anti-Beta-actin Antibody

 Product Synonym Names    Actin, cytoplasmic 1
 Product Gene Name   

anti-ACTB antibody

[Similar Products]
 Antibody/Peptide Pairs    Beta-actin peptide (MBS824344) is used for blocking the activity of Beta-actin antibody (MBS821786)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 607371
 3D Structure    ModBase 3D Structure for P60709
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Bovine, Chicken, Dog, Monkey, Pig, Rabbit, Sheep
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 Specificity    Recognizes endogenous levels of Beta-actin protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Entrez Gene    60 (human; 11461(Mouse); 81822 (Rat)
 SwissProt    P60709 (Human); P60710 (Mouse); P60711 (Rat)
 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Beta-actin. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-ACTB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ACTB antibody

   Rabbit polyclonal antibody to Beta-actin
 Applications Tested/Suitable for anti-ACTB antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ACTB antibody    WB (1/500 - 1/1000), IH (1/100 - 1/200)
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 Western Blot (WB) of anti-ACTB antibody    Western blot analysis of Beta-actin expression in Jurkat (A), HeLa (B), NIH3T3 (C), rat liver (D) whole cell lysates.
anti-ACTB antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ACTB antibody    Immunohistochemical analysis of Beta-actin staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-ACTB antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ACTB. It may not necessarily be applicable to this product.
 NCBI GI #    4501885
 NCBI GeneID    60
 NCBI Accession #    NP_001092.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001101.3 [Other Products]
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 UniProt Primary Accession #    P60709 [Other Products]
 UniProt Secondary Accession #    P02570; P70514; P99021; Q11211; Q64316; Q75MN2; Q96B34; Q96HG5 [Other Products]
 UniProt Related Accession #    P60709 [Other Products]
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 NCBI Official Full Name    actin, cytoplasmic 1
 NCBI Official Synonym Full Names    actin, beta
 NCBI Official Symbol    ACTB [Similar Products]
 NCBI Official Synonym Symbols   
BRWS1; PS1TP5BP1
[Similar Products]
 NCBI Protein Information    actin, cytoplasmic 1; beta cytoskeletal actin; PS1TP5-binding protein 1
 UniProt Protein Name    Actin, cytoplasmic 1
 UniProt Synonym Protein Names   
Beta-actinCleaved into the following chain:Actin, cytoplasmic 1, N-terminally processed
 Protein Family    Beta-actin-like protein
 UniProt Gene Name    ACTB [Similar Products]
 UniProt Entry Name    ACTB_HUMAN
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 NCBI Summary for ACTB    This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACTB    ACTB: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCET2. Belongs to the actin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: cortical cytoskeleton; extracellular space; NuA4 histone acetyltransferase complex; protein complex; focal adhesion; postsynaptic density; ribonucleoprotein complex; cytosol; nucleoplasm; cytoskeleton; membrane; axon; nuclear chromatin; cytoplasm; plasma membrane

Molecular Function: protein binding; nucleosomal DNA binding; structural constituent of cytoskeleton; kinesin binding; Tat protein binding; nitric-oxide synthase binding; protein kinase binding; ATP binding

Biological Process: axon guidance; intercellular junction assembly and maintenance; establishment and/or maintenance of chromatin architecture; protein folding; 'de novo' posttranslational protein folding; retinal homeostasis; substantia nigra development; cellular protein metabolic process; ephrin receptor signaling pathway; ATP-dependent chromatin remodeling; innate immune response; vascular endothelial growth factor receptor signaling pathway; cell motility; blood coagulation

Disease: Dystonia, Juvenile-onset; Baraitser-winter Syndrome 1
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 Research Articles on ACTB    1. Downregulation of the HuR gene results in decreased beta-actin gene expression, which in turn results in decreased motility and proliferation of corneal fibroblasts.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ACTB antibodyDiseases associated with anti-ACTB antibody
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Chaperonin-mediated Protein Folding Pathway antibodies  Chaperonin-mediated Protein Folding Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >49 publications with ACTB and Carcinoma
 Liver Diseases Antibodies  >23 publications with ACTB and Liver Diseases
 Brain Diseases Antibodies  >21 publications with ACTB and Brain Diseases
 Disease Models, Animal Antibodies  >19 publications with ACTB and Disease Models, Animal
 Kidney Diseases Antibodies  >16 publications with ACTB and Kidney Diseases
 Lung Diseases Antibodies  >15 publications with ACTB and Lung Diseases
 Necrosis Antibodies  >13 publications with ACTB and Necrosis
 Liver Neoplasms Antibodies  >12 publications with ACTB and Liver Neoplasms
 Heart Diseases Antibodies  >11 publications with ACTB and Heart Diseases
 Inflammation Antibodies  >10 publications with ACTB and Inflammation
Organs/Tissues associated with anti-ACTB antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >71 publications with ACTB and Blood
 Brain Antibodies  >53 publications with ACTB and Brain
 Liver Antibodies  >52 publications with ACTB and Liver
 Muscle Antibodies  >49 publications with ACTB and Muscle
 Kidney Antibodies  >34 publications with ACTB and Kidney
 Bone Antibodies  >27 publications with ACTB and Bone
 Lung Antibodies  >26 publications with ACTB and Lung
 Heart Antibodies  >25 publications with ACTB and Heart
 Connective Tissue Antibodies  >20 publications with ACTB and Connective Tissue
 Embryonic Tissue Antibodies  >19 publications with ACTB and Embryonic Tissue
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