View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Add To Compare List anti-BCL2L11 antibody :: Rabbit anti-Human Bim Polyclonal Antibody Catalog # MBS126525 (SPECIAL PROMOTION: Get FREE $5 Amazon gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) Unit / Price DISCONTINUEDYou will be redirected to our replacement product Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Bim (BCL2L11), Polyclonal Antibody Popular Item Full Product Name Bim Product Synonym Names BCL2L11; Bim Product Gene Name anti-BCL2L11 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Chromosome Location Chromosome: 2; NC_000002.11 (111878491..111926022). Location: 2q13 OMIM 603827 3D Structure ModBase 3D Structure for O43521 Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human Purity/Purification Affinity purification Category Polyclonal Antibodies Observed MW 30kDa Calculated MW 4-22kDa Immunogen A synthetic peptide of human BCL2L11 Buffer PBS with 0.02% sodium azide, pH7.3. Preparation and Storage Store at 4 degree C. Avoid freeze / thaw cycles. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of anti-BCL2L11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-BCL2L11 antibody The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. Applications Tested/Suitable for anti-BCL2L11 antibody WB, IHC, FC Application Notes for anti-BCL2L11 antibody WB 1:500 - 1:1000IHC 1:20 - 1:50FC 1:20 - 1:50 Western Blot (WB) of anti-BCL2L11 antibody Western blot analysis of extracts of various cell lines, using BCL2L11 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s. TOP NCBI/Uniprot data below describe general gene information for BCL2L11. It may not necessarily be applicable to this product. NCBI GI # 323362959 NCBI GeneID 10018 NCBI Accession # NP_001191035.1 [Other Products] NCBI GenBank Nucleotide # NM_001204106.1 [Other Products] UniProt Primary Accession # O43521 [Other Products] UniProt Secondary Accession # O43522; Q0MSE7; Q0MSE8; Q0MSE9; Q53R28; Q6JTU6; Q6T851; Q6TE14; Q6TE15; Q6TE16; A8K2W2[Other Products] UniProt Related Accession # O43521[Other Products] TOP NCBI Official Full Name bcl-2-like protein 11 isoform 11 NCBI Official Synonym Full Names BCL2-like 11 (apoptosis facilitator) NCBI Official Symbol BCL2L11 [Similar Products] NCBI Official Synonym Symbols BAM; BIM; BOD [Similar Products] NCBI Protein Information bcl-2-like protein 11; bcl-2 interacting protein Bim; bcl-2-related ovarian death agonist; bcl-2 interacting mediator of cell death UniProt Protein Name Bcl-2-like protein 11 UniProt Synonym Protein Names Bcl2-interacting mediator of cell death Protein Family Bcl-2-like protein UniProt Gene Name BCL2L11 [Similar Products] UniProt Synonym Gene Names BIM; Bcl2-L-11 [Similar Products] UniProt Entry Name B2L11_HUMAN TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Pathways associated with anti-BCL2L11 antibody Products by Pathway Pathway Diagram Activation Of BH3-only Proteins Pathway antibodies Activation Of BH3-only Proteins Pathway Diagram Activation Of BIM And Translocation To Mitochondria Pathway antibodies Activation Of BIM And Translocation To Mitochondria Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Apoptosis Modulation And Signaling Pathway antibodies Apoptosis Modulation And Signaling Pathway Diagram B Cell Receptor Signaling Pathway antibodies B Cell Receptor Signaling Pathway Diagram BDNF Signaling Pathway antibodies BDNF Signaling Pathway Diagram BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway antibodies BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway Diagram Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram DNA Damage Response (only ATM Dependent) Pathway antibodies DNA Damage Response (only ATM Dependent) Pathway Diagram Diseases associated with anti-BCL2L11 antibody Disease Name Pubmed Publications Neoplasms Antibodies >35 publications with BCL2L11 and Neoplasms Adenocarcinoma Antibodies >8 publications with BCL2L11 and Adenocarcinoma Necrosis Antibodies >5 publications with BCL2L11 and Necrosis Nervous System Diseases Antibodies >4 publications with BCL2L11 and Nervous System Diseases Drug Toxicity Antibodies >3 publications with BCL2L11 and Drug Toxicity Brain Diseases Antibodies >3 publications with BCL2L11 and Brain Diseases Neoplasm Metastasis Antibodies >3 publications with BCL2L11 and Neoplasm Metastasis Liver Diseases Antibodies >2 publications with BCL2L11 and Liver Diseases Kidney Diseases Antibodies >2 publications with BCL2L11 and Kidney Diseases Inflammation Antibodies >2 publications with BCL2L11 and Inflammation Organs/Tissues associated with anti-BCL2L11 antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >12 publications with BCL2L11 and Blood Brain Antibodies >4 publications with BCL2L11 and Brain Thymus Antibodies >2 publications with BCL2L11 and Thymus Muscle Antibodies >2 publications with BCL2L11 and Muscle Embryonic Tissue Antibodies >1 publications with BCL2L11 and Embryonic Tissue Skin Antibodies >1 publications with BCL2L11 and Skin Testis Antibodies >1 publications with BCL2L11 and Testis TOP © 2006-24 MyBioSource.com. 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