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anti-BPNT1 antibody :: Goat Bisphosphate 3'-nucleotidase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420859
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bisphosphate 3'-nucleotidase (BPNT1), Polyclonal Antibody

 Also Known As   

Goat anti-Bisphosphate 3'-nucleotidase Antibody

 Product Synonym Names    bisphosphate 3'-nucleotidase; 3'(2'), 5'-bisphosphate nucleotidase 1; PIP; BPntase; PAP-inositol-1,4-phosphatase; bisphosphate 3\1-nucleotidase antibody; 3\1(2\1); 5\1-bisphosphate nucleotidase 1 antibody; PIP antibody; BPntase antibody; PAP-inositol-1; 4-phosphatase antibody; Bisphosphate 3'-nucleotidase; Bisphosphate 3'-nucleotidase
 Product Gene Name   

anti-BPNT1 antibody

[Similar Products]
 Antibody/Peptide Pairs    Bisphosphate 3'-nucleotidase peptide (MBS425968) is used for blocking the activity of Bisphosphate 3'-nucleotidase antibody (MBS420859)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    RNYDYYASRV PESIK
 OMIM    604053
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-RNYDYYASRVPESIK, from the C Terminus of the protein sequence according to NP_006076.4.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-BPNT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-BPNT1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-BPNT1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Approx 37kDa band observed in Human Liver lysates (calculated MW of 33.4kDa according to NP_006076.4). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Spiegelberg et al, J Biol Chem.1999 May 7;274(19): 13619-28.; PMID: 10224133). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-BPNT1 antibody    (1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-BPNT1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for BPNT1. It may not necessarily be applicable to this product.
 NCBI GI #    116812595
 NCBI GeneID    10380
 NCBI Accession #    NP_006076.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_006085.5 [Other Products]
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 UniProt Secondary Accession #    Q8WVL5; Q9UGJ3; A8K7C8; B4DPS5; B4DUS9; D3DTA9 [Other Products]
 UniProt Related Accession #    O95861 [Other Products]
 Molecular Weight    29,189 Da
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 NCBI Official Full Name    3'(2'),5'-bisphosphate nucleotidase 1 isoform 1
 NCBI Official Synonym Full Names    3'(2'), 5'-bisphosphate nucleotidase 1
 NCBI Official Symbol    BPNT1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    3'(2'),5'-bisphosphate nucleotidase 1
 UniProt Protein Name    3'(2'),5'-bisphosphate nucleotidase 1
 UniProt Synonym Protein Names   
Bisphosphate 3'-nucleotidase 1; PAP-inositol 1,4-phosphatase; PIP
 UniProt Gene Name    BPNT1 [Similar Products]
 UniProt Synonym Gene Names    PIP [Similar Products]
 UniProt Entry Name    BPNT1_HUMAN
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 NCBI Summary for BPNT1    BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BPNT1    BPNT1: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6. Belongs to the inositol monophosphatase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; EC; Energy Metabolism - sulfur; Phosphatase (non-protein)

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: cytoplasm; cytosol

Molecular Function: 3'(2'),5'-bisphosphate nucleotidase activity; inositol-1,4-bisphosphate 1-phosphatase activity; magnesium ion binding

Biological Process: 3'-phosphoadenosine 5'-phosphosulfate metabolic process; dephosphorylation; nervous system development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; phosphoinositide phosphorylation
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 Research Articles on BPNT1    1. Meta-analysis of gene-disease association. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-BPNT1 antibodyDiseases associated with anti-BPNT1 antibody
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cytosolic Sulfonation Of Small Molecules Pathway antibodies  Cytosolic Sulfonation Of Small Molecules Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Phase II Conjugation Pathway antibodies  Phase II Conjugation Pathway Diagram
 Sulfur Metabolism Pathway antibodies  Sulfur Metabolism Pathway Diagram
 Sulfur Metabolism Pathway antibodies  Sulfur Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Edema Antibodies  >1 publications with BPNT1 and Edema
 Inflammation Antibodies  >1 publications with BPNT1 and Inflammation
Organs/Tissues associated with anti-BPNT1 antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with BPNT1 and Kidney
 Liver Antibodies  >2 publications with BPNT1 and Liver
 Intestine Antibodies  >1 publications with BPNT1 and Intestine
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