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anti-IBSP antibody :: Rabbit Bone Sialoprotein Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175104
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bone Sialoprotein (IBSP), Polyclonal Antibody

 Also Known As   

Anti-Bone Sialoprotein antibody

 Product Synonym Names    Bone sialoprotein 2; integrin-binding sialoprotein; BNSP antibody; Bone sialoprotein 2 antibody; Bone sialoprotein 2 precursor antibody; Bone sialoprotein II antibody; bone sialoprotein II; bone sialoprotein antibody; BSP antibody; BSP II antibody; BSPII antibody; Cell binding sialoprotein antibody; Cell-binding sialoprotein antibody; IBSP antibody; Integrin binding sialoprotein antibody; Integrin binding sialoprotein(bone sialoprotein II) antibody; integrin binding sialoprotein(bone sialoprotein, bone sialoprotein II) antibody; Integrin-binding sialoprotein antibody; SIAL_HUMAN antibody; SPII antibody
 Product Gene Name   

anti-IBSP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147563
 3D Structure    ModBase 3D Structure for P21815
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the N-terminus of human Bone Sialoprotein (17-34aa FSMKNLHRRVKIEDSEEN), different from the related rat and mouse sequences by three amino acids.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IBSP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IBSP antibody

   Description: Rabbit IgG polyclonal antibody for Bone sialoprotein 2(IBSP) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: BSP is also known as IBSP(integrin-binding sialoprotein). The protein encoded by this gene is a major structural protein of the bone matrix. Bone sialoprotein is an acidic glycoprotein of approximately 70 kD that undergoes extensive posttranslational modifications. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. The BSP gene is mapped to 4q22.1.
 Applications Tested/Suitable for anti-IBSP antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

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 Immunohistochemistry (IHC) of anti-IBSP antibody    Anti-Bone Sialoprotein antibody, MBS175104, IHC(P)
IHC(P): Human Osteosarcoma Tissue
anti-IBSP antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for IBSP. It may not necessarily be applicable to this product.
 NCBI GI #    317373545
 NCBI GeneID    3381
 NCBI Accession #    P21815.4 [Other Products]
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 UniProt Primary Accession #    P21815 [Other Products]
 UniProt Related Accession #    P21815 [Other Products]
 Molecular Weight    35,148 Da
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 NCBI Official Full Name    Bone sialoprotein 2
 NCBI Official Synonym Full Names    integrin-binding sialoprotein
 NCBI Official Symbol    IBSP [Similar Products]
 NCBI Official Synonym Symbols   
BSP; BNSP; SP-II; BSP-II
[Similar Products]
 NCBI Protein Information    bone sialoprotein 2; BSP II; bone sialoprotein II; cell-binding sialoprotein
 UniProt Protein Name    Bone sialoprotein 2
 UniProt Synonym Protein Names   
Bone sialoprotein II; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein
 Protein Family    Bone sialoprotein
 UniProt Gene Name    IBSP [Similar Products]
 UniProt Synonym Gene Names    BNSP; BSP II [Similar Products]
 UniProt Entry Name    SIAL_HUMAN
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 NCBI Summary for IBSP    The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IBSP    Sialoprotein-2: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.

Protein type: Secreted, signal peptide; Secreted; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: extracellular space; membrane; extracellular region

Biological Process: osteoblast differentiation; extracellular matrix organization and biogenesis; biomineral formation; cell adhesion
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 Research Articles on IBSP    1. Current evidence demonstrates that BSP and OPN, play significant roles in bone metastasis of osteotropic malignancies derived from breast, prostate, lung, thyroid, and multiple myeloma. [review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IBSP antibodyPathways associated with anti-IBSP antibody
 Reference Product  PubMed Publications
 SPP1 antibody  >195 publications with IBSP and SPP1
 FGF2 antibody  >26 publications with IBSP and FGF2
 BGLAP antibody  >14 publications with IBSP and BGLAP
 ITGA2B antibody  >1 publications with IBSP and ITGA2B
 ITGB3 antibody  >1 publications with IBSP and ITGB3
 ITGAV antibody  >1 publications with IBSP and ITGAV
 Products by Pathway  Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Interleukin-11 Signaling Pathway antibodies  Interleukin-11 Signaling Pathway Diagram
 Osteoblast Signaling Pathway antibodies  Osteoblast Signaling Pathway Diagram
Diseases associated with anti-IBSP antibodyOrgans/Tissues associated with anti-IBSP antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >42 publications with IBSP and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >24 publications with IBSP and Neoplasm Metastasis
 Kidney Diseases Antibodies  >14 publications with IBSP and Kidney Diseases
 Neoplasms, Experimental Antibodies  >12 publications with IBSP and Neoplasms, Experimental
 Prostatic Neoplasms Antibodies  >11 publications with IBSP and Prostatic Neoplasms
 Inflammation Antibodies  >9 publications with IBSP and Inflammation
 Lung Diseases Antibodies  >9 publications with IBSP and Lung Diseases
 Necrosis Antibodies  >6 publications with IBSP and Necrosis
 Neoplasm Invasiveness Antibodies  >6 publications with IBSP and Neoplasm Invasiveness
 Nervous System Diseases Antibodies  >6 publications with IBSP and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >667 publications with IBSP and Bone
 Connective Tissue Antibodies  >186 publications with IBSP and Connective Tissue
 Embryonic Tissue Antibodies  >38 publications with IBSP and Embryonic Tissue
 Brain Antibodies  >7 publications with IBSP and Brain
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