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anti-IBSP antibody :: Rabbit anti-Human Bone Sialoprotein Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS315321 anti-IBSP antibody
Unit / Price
0.02 mL  /  $240 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bone Sialoprotein (IBSP), Polyclonal Antibody

 Also Known As   

Rabbit anti Sialoprotein

 Product Synonym Names    Rabbit Antibody to Human Bone Sialoprotein (BSP)
 Product Gene Name   

anti-IBSP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (88720702..88733601). Location: 4q21.1
 OMIM    147563
 3D Structure    ModBase 3D Structure for P21815
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Bone Sialoprotein
Human Bone Sialoprotein, rat Bone Sialoprotein. No cross reactivity with human Osteonectin or human Osteopontin.
 Form/Format    Neat, Lyophilized.
Reconstitute in 20ul double distilled water.
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 Immunogen    Human Bone Sialoprotein (Bone extract)
 Buffer    Not applicable.
 Preservative    No
 Lyophilized    Yes
 Important Note    Vial Contains Small Quantity. Centrifuge Product Before Opening!
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 Preparation and Storage    Store lyophilized product at 2 to 8 degree C. After reconstitution, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IBSP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-IBSP antibody    Polyclonal Antibodies for Bone and Calcium Metabolism
NCBI/Uniprot data below describe general gene information for IBSP. It may not necessarily be applicable to this product.
 NCBI GI #    292494
 NCBI GeneID    3381
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 UniProt Primary Accession #    P21815 [Other Products]
 UniProt Related Accession #    P21815 [Other Products]
 Molecular Weight    35,148 Da [Similar Products]
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 NCBI Official Full Name    bone sialoprotein
 NCBI Official Synonym Full Names    integrin-binding sialoprotein
 NCBI Official Symbol    IBSP [Similar Products]
 NCBI Official Synonym Symbols   
BSP; BNSP; SP-II; BSP-II
[Similar Products]
 NCBI Protein Information    bone sialoprotein 2; BSP II; OTTHUMP00000161175; bone sialoprotein II; cell-binding sialoprotein
 UniProt Protein Name    Bone sialoprotein 2
 UniProt Synonym Protein Names   
Bone sialoprotein II; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein
 Protein Family    Bone sialoprotein
 UniProt Gene Name    IBSP [Similar Products]
 UniProt Synonym Gene Names    BNSP [Similar Products]
 UniProt Entry Name    SIAL_HUMAN
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 NCBI Summary for IBSP    The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq]
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 UniProt Comments for IBSP    Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.

Subcellular location: Secreted.

Post-translational modification: N-glycosylated; glycans consist of sialated and core-fucosylated bi-, tri- and tetraantennary chains. Ref.6O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc. Ref.6Sulfated on either Tyr-313 or Tyr-314.

Miscellaneous: It is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite.
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 Research Articles on IBSP    1. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-IBSP antibodyDiseases associated with anti-IBSP antibody
 Products by Pathway  Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Osteoblast Signaling Pathway antibodies  Osteoblast Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >94 publications with IBSP and Neoplasms
 Bone Neoplasms Antibodies  >73 publications with IBSP and Bone Neoplasms
 Bone Resorption Antibodies  >60 publications with IBSP and Bone Resorption
 Breast Neoplasms Antibodies  >42 publications with IBSP and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >24 publications with IBSP and Neoplasm Metastasis
 Osteoporosis Antibodies  >20 publications with IBSP and Osteoporosis
 Cardiovascular Diseases Antibodies  >16 publications with IBSP and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >13 publications with IBSP and Lung Neoplasms
 Kidney Diseases Antibodies  >13 publications with IBSP and Kidney Diseases
 Prostatic Neoplasms Antibodies  >11 publications with IBSP and Prostatic Neoplasms
Organs/Tissues associated with anti-IBSP antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >618 publications with IBSP and Bone
 Connective Tissue Antibodies  >177 publications with IBSP and Connective Tissue
 Embryonic Tissue Antibodies  >34 publications with IBSP and Embryonic Tissue
 Brain Antibodies  >6 publications with IBSP and Brain
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