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anti-BDKRB1 antibody :: Goat Bradykinin receptor B1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420159
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bradykinin receptor B1 (BDKRB1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-Bradykinin receptor B1 Antibody

 Product Synonym Names    bradykinin receptor B1; BDKRB1; B1BKR; B1R; BKB1R; BKR1; BRADYB1; BK-1 receptor; bradykinin B1 receptor; bradykinin receptor 1; bradykinin receptor B1 antibody; BDKRB1 antibody; B1BKR antibody; B1R antibody; BKB1R antibody; BKR1 antibody; BRADYB1 antibody; BK-1 receptor antibody; bradykinin B1 receptor antibody; bradykinin receptor 1 antibody; Bradykinin receptor B1; Bradykinin receptor B1
 Product Gene Name   

anti-BDKRB1 antibody

[Similar Products]
 Antibody/Peptide Pairs    Bradykinin receptor B1 peptide (MBS426221) is used for blocking the activity of Bradykinin receptor B1 antibody (MBS420159)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KVWELYKQCT PK
 OMIM    600337
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence KVWELYKQCTPK, from the internal region of the protein sequence according to NP_000701.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-BDKRB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-BDKRB1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-BDKRB1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 1000.
Western Blot: Approx 35kDa band observed in lysates of cell lines Daudi, K562 and U937 calculated MW of 40.5kDa according to NP_000701.2). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. Recommended concentration: 2-4ug/ml.
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 Western Blot (WB) of anti-BDKRB1 antibody    (2ug/ml) staining of K562 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-BDKRB1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for BDKRB1. It may not necessarily be applicable to this product.
 NCBI GI #    20544172
 NCBI GeneID    623
 NCBI Accession #    NP_000701.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000710.3 [Other Products]
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 UniProt Secondary Accession #    Q546S7; Q8N0Y8; A8K7F5 [Other Products]
 UniProt Related Accession #    P46663 [Other Products]
 Molecular Weight    40,495 Da
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 NCBI Official Full Name    B1 bradykinin receptor
 NCBI Official Synonym Full Names    bradykinin receptor B1
 NCBI Official Symbol    BDKRB1 [Similar Products]
 NCBI Official Synonym Symbols   
B1R; BKR1; B1BKR; BKB1R; BDKRB2; BRADYB1
[Similar Products]
 NCBI Protein Information    B1 bradykinin receptor
 UniProt Protein Name    B1 bradykinin receptor
 Protein Family    B1 bradykinin receptor
 UniProt Gene Name    BDKRB1 [Similar Products]
 UniProt Synonym Gene Names    BRADYB1; B1R; BK-1 receptor [Similar Products]
 UniProt Entry Name    BKRB1_HUMAN
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 NCBI Summary for BDKRB1    Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
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 UniProt Comments for BDKRB1    BKR1: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 14q32.1-q32.2

Cellular Component: endoplasmic reticulum; integral to plasma membrane; neuron projection; plasma membrane

Molecular Function: bradykinin receptor activity; peptide binding; protein binding

Biological Process: cell migration; elevation of cytosolic calcium ion concentration; inflammatory response; negative regulation of blood pressure; negative regulation of cell growth; negative regulation of protein amino acid phosphorylation; positive regulation of leukocyte migration; positive regulation of release of sequestered calcium ion into cytosol; protein kinase C activation; response to lipopolysaccharide; response to mechanical stimulus; sensory perception of pain
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 Research Articles on BDKRB1    1. promotes adhesion of neutrophils to endothelial cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-BDKRB1 antibodyDiseases associated with anti-BDKRB1 antibody
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with BDKRB1 and Inflammation
 Disease Models, Animal Antibodies  >3 publications with BDKRB1 and Disease Models, Animal
 Necrosis Antibodies  >3 publications with BDKRB1 and Necrosis
 Lung Diseases Antibodies  >2 publications with BDKRB1 and Lung Diseases
 Kidney Diseases Antibodies  >2 publications with BDKRB1 and Kidney Diseases
 Hypertension Antibodies  >2 publications with BDKRB1 and Hypertension
 Cardiovascular Diseases Antibodies  >2 publications with BDKRB1 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >2 publications with BDKRB1 and Vascular Diseases
 Pain Antibodies  >2 publications with BDKRB1 and Pain
 Fibrosis Antibodies  >1 publications with BDKRB1 and Fibrosis
Organs/Tissues associated with anti-BDKRB1 antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3 publications with BDKRB1 and Kidney
 Lung Antibodies  >3 publications with BDKRB1 and Lung
 Bone Antibodies  >2 publications with BDKRB1 and Bone
 Vascular Antibodies  >2 publications with BDKRB1 and Vascular
 Skin Antibodies  >2 publications with BDKRB1 and Skin
 Brain Antibodies  >1 publications with BDKRB1 and Brain
 Connective Tissue Antibodies  >1 publications with BDKRB1 and Connective Tissue
 Testis Antibodies  >1 publications with BDKRB1 and Testis
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