AAH62556.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
93,291 Da
NCBI Official Full Name
Breast cancer anti-estrogen resistance 1
NCBI Official Synonym Full Names
BCAR1, Cas family scaffolding protein
NCBI Official Synonym Symbols
CAS; CAS1; CASS1; CRKAS; P130Cas [Similar Products]
NCBI Protein Information
breast cancer anti-estrogen resistance protein 1
UniProt Protein Name
Breast cancer anti-estrogen resistance protein 1
UniProt Synonym Protein Names
CRK-associated substrate; Cas scaffolding protein family member 1; p130cas
UniProt Synonym Gene Names
NCBI Summary for BCAR1
The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017]
UniProt Comments for BCAR1
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.
Research Articles on BCAR1
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Products associated with anti-BCAR1 antibody
Pathways associated with anti-BCAR1 antibody
Diseases associated with anti-BCAR1 antibody
Organs/Tissues associated with anti-BCAR1 antibody
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