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anti-C-myc antibody :: Chicken C-myc Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS534611 anti-C-myc antibody
Unit / Price
0.2 mg  /  $430 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C-myc, Polyclonal Antibody

 Also Known As   

C-myc antibody

 Product Synonym Names    Polyclonal C-myc; Anti-C-myc
 Product Gene Name   

anti-C-myc antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q6LBK7
 Clonality    Polyclonal
 Isotype    IgG
 Host    Chicken
 Species Reactivity    To be determined by end-user
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 Purity/Purification    C-myc antibody was purified by affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2 with 0.1% NaN3.
 Concentration    1.0 mg/ml (lot specific)
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 Biological Significance    Myc gene encodes a transcription factor that is believed to regulate expression of 15% of all genes through binding of Enhancer Box sequences (E-boxes) and recruiting histone acetyltransferases (HATs). This means that in addition to its role as a classical transcription factor, Myc also functions to regulate global chromatin structure.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    C-myc antibody was raised in chicken using residues 410-419 (EQKLISEEDL) of human myc conjugated to KLH as the immunogen.
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of anti-C-myc antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-C-myc antibody

   Chicken polyclonal C-myc antibody
 Product Categories/Family for anti-C-myc antibody    Cancer
 Applications Tested/Suitable for anti-C-myc antibody   

ELISA (EIA), Immunocytochemistry (ICC), Western Blot (WB)

 Application Notes for anti-C-myc antibody    ELISA: coating:1:100-1:500
ICC: 1:100-1:400
WB: colorimetric: 1:1,000-1:10,000
chemiluminescent: 1:1,000-1:30,000
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NCBI/Uniprot data below describe general gene information for C-myc. It may not necessarily be applicable to this product.
 NCBI GI #    396512
 NCBI GeneID    4609
 NCBI Accession #    CAA46984.1 [Other Products]
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 UniProt Primary Accession #    Q6LBK7 [Other Products]
 UniProt Related Accession #    P01106 [Other Products]
 Molecular Weight    7,012 Da
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 NCBI Official Full Name    c-myc, partial
 NCBI Official Synonym Full Names    v-myc avian myelocytomatosis viral oncogene homolog
 NCBI Official Symbol    MYC [Similar Products]
 NCBI Official Synonym Symbols   
MRTL; MYCC; c-Myc; bHLHe39
[Similar Products]
 NCBI Protein Information    myc proto-oncogene protein
 UniProt Protein Name    C-myc protein
 UniProt Synonym Protein Names   
C-myc protein
 Protein Family    C-Myc-binding protein
 UniProt Gene Name    c-myc [Similar Products]
 UniProt Entry Name    Q6LBK7_HUMAN
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 NCBI Summary for C-myc    The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for C-myc    Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.

Protein type: Oncoprotein; DNA-binding; Nucleolus; Transcription factor

Chromosomal Location of Human Ortholog: 8q24.21

Cellular Component: nucleoplasm; protein complex; nucleolus; nucleus; cytosol

Molecular Function: protein dimerization activity; protein binding; DNA binding; protein complex binding; transcription factor activity; transcription factor binding

Biological Process: oxygen transport; cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; chromosome organization and biogenesis; positive regulation of fibroblast proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; response to gamma radiation; cell cycle arrest; response to drug; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; transcription, DNA-dependent; regulation of telomere maintenance; MAPKKK cascade; negative regulation of cell division; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; chromatin remodeling; ureteric bud branching; negative regulation of fibroblast proliferation; regulation of gene expression; energy reserve metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; positive regulation of epithelial cell proliferation; negative regulation of apoptosis

Disease: Burkitt Lymphoma
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 Research Articles on C-myc    1. C-MYC overexpression may play an important role in aggressive transformation and is an independent prognostic factor in MALT lymphoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-C-myc antibodyPathways associated with anti-C-myc antibody
 Reference Product  PubMed Publications
 MAX antibody  >1016 publications with C-myc and MAX
 CDKN2A antibody  >465 publications with C-myc and CDKN2A
 FBXW7 antibody  >110 publications with C-myc and FBXW7
 SKP2 antibody  >91 publications with C-myc and SKP2
 ZBTB17 antibody  >48 publications with C-myc and ZBTB17
 EP300 antibody  >20 publications with C-myc and EP300
 KAT5 antibody  >14 publications with C-myc and KAT5
 PFDN5 antibody  >13 publications with C-myc and PFDN5
 GSK3B antibody  >7 publications with C-myc and GSK3B
 SUPT3H antibody  >4 publications with C-myc and SUPT3H
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 C-MYC Pathway antibodies  C-MYC Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
Organs/Tissues associated with anti-C-myc antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3657 publications with C-myc and Blood
 Liver Antibodies  >2025 publications with C-myc and Liver
 Lung Antibodies  >1480 publications with C-myc and Lung
 Bone Antibodies  >1396 publications with C-myc and Bone
 Brain Antibodies  >1244 publications with C-myc and Brain
 Muscle Antibodies  >1163 publications with C-myc and Muscle
 Bone Marrow Antibodies  >975 publications with C-myc and Bone Marrow
 Vascular Antibodies  >942 publications with C-myc and Vascular
 Kidney Antibodies  >859 publications with C-myc and Kidney
 Prostate Antibodies  >773 publications with C-myc and Prostate
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