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anti-SERPING1 antibody :: Goat anti-Human C1 Esterase Inhibitor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS629240 anti-SERPING1 antibody
Unit / Price
1 mg  /  $315 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C1 Esterase Inhibitor (SERPING1), Polyclonal Antibody

★Popular Item★
 Also Known As   

C1 Esterase Inhibitor (C1-INH)

 Product Synonym Names    Anti -C1 Esterase Inhibitor (C1-INH)
 Product Gene Name   

anti-SERPING1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (57365027..57382326). Location: 11q12.1
 OMIM    106100
 3D Structure    ModBase 3D Structure for P05155
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Human
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 Specificity    Recognizes human C1 esterase inhibitor as determined by immunoelectrophoresis and ELISA.
 Purity/Purification    Purified
Purified by caprylic acid and ammonium sulfate precipitations, and solid -phase adsorption to remove unwanted crossreactivity.
 Form/Format    Supplied in a solution of 10mM HEPES, pH7.4, 0.15M sodium chloride and 50% glycerol.
 Concentration    5mg/ml (lot specific)
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 Immunogen    C1 esterase Inhibitor (also called C1-Inactivator) purified from human plasma.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-SERPING1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SERPING1 antibody

   C1-INH is a member of the serpin family of proteases, as are alpha-antitrypsin, antithrombin III, and angiotensinogen. These proteins stoichiometrically inactivate their target proteases by forming stable, one-to-one complexes with the protein to be inhibited. Although synthesized primarily by hepatocytes, C1-INH is also synthesized by monocytes. The regulation of the protein production is not completely understood, but, since patients respond clinically to androgen therapy serum levels of C1-INH increase, it is believed that androgens may stimulate C1-INH synthesis. All C1-INH deficient patients are heterozygous; half the normal level of C1-INH is not believed sufficient to prevent attacks.

Although named for its action on the first component of complement (C1 esterase), C1-INH also inhibits components of the fibrinolytic, clotting, and kinin pathways. Specifically, C1-INH inactivates plasmin-activated Hageman factor (factor XII), activated factor XI, PTA, and kallikrein. Within the complement system, C1-INH blocks the activation of C1 and the rest of the classic complement pathway by binding to C1r and C1s. Without C1-INH, unchecked activation of C1, C2, and C4 occur before other inhibitors (C4-binding protein and factor I) can halt the cascade.
The actual factor or factors responsible for the edema formation remain somewhat controversial. Researchers have demonstrated activation of the kinin system and increased bradykinin concentration associated with clinical flares. Bradykinin is an important inflammatory mediator that causes neutrophil chemotaxis, capillary dilation, and smooth muscle relaxation, and it has been linked to other forms of angioedema. In an animal model of C1-INH deficiency, bradykinin antagonists prevent capillary leakage. Others implicate C2 kinin, a metabolite of C2b, as the active agent in the presence of plasmin.
 Product Categories/Family for anti-SERPING1 antibody    Antibodies; Abs to Protease Inhibitors
 Applications Tested/Suitable for anti-SERPING1 antibody   

ELISA (EL/EIA), Immunoelectrophoresis

 Application Notes for anti-SERPING1 antibody    Suitable for use as a source of affinity purified goat antibodies to human C1-Inhibitor. Optimal dilutions to be determined by the researcher. Other applications not tested.
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NCBI/Uniprot data below describe general gene information for SERPING1. It may not necessarily be applicable to this product.
 NCBI GI #    20385946
 NCBI GeneID    710
 NCBI Accession #    AAM21515.1 [Other Products]
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 UniProt Primary Accession #    P05155 [Other Products]
 UniProt Secondary Accession #    Q16304; Q547W3; Q59EI5; Q7Z455; Q96FE0; Q9UC49; Q9UCF9; A6NMU0; A8KAI9; B2R6L5 [Other Products]
 UniProt Related Accession #    P05155 [Other Products]
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 NCBI Official Full Name    C1 esterase inhibitor
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
 NCBI Official Symbol    SERPING1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    plasma protease C1 inhibitor; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1
 UniProt Protein Name    Plasma protease C1 inhibitor
 UniProt Synonym Protein Names   
C1 esterase inhibitor; C1-inhibiting factor; Serpin G1
 Protein Family    Plasma protease C1 inhibitor
 UniProt Gene Name    SERPING1 [Similar Products]
 UniProt Synonym Gene Names    C1IN; C1NH; C1 Inh; C1Inh [Similar Products]
 UniProt Entry Name    IC1_HUMAN
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 NCBI Summary for SERPING1    This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SERPING1    SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding

Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; complement activation, classical pathway; blood coagulation, intrinsic pathway; aging

Disease: Complement Component 4, Partial Deficiency Of; Angioedema, Hereditary, Type I
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 Research Articles on SERPING1    1. Our study identified four novel mutations in the Slovenian HAE population, highlighting the heterogeneity of mutations in the SERPING1 gene causing C1 inhibitor deficiency and Hereditary angioedema .
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SERPING1 antibodyDiseases associated with anti-SERPING1 antibody
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Disease Name  Pubmed Publications
 Angioedemas, Hereditary Antibodies  >75 publications with SERPING1 and Angioedemas, Hereditary
 Edema Antibodies  >55 publications with SERPING1 and Edema
 Inflammation Antibodies  >23 publications with SERPING1 and Inflammation
 Hereditary Angioedema Types I and II Antibodies  >14 publications with SERPING1 and Hereditary Angioedema Types I and II
 Acquired angioedema Antibodies  >11 publications with SERPING1 and Acquired angioedema
 Disease Models, Animal Antibodies  >10 publications with SERPING1 and Disease Models, Animal
 Brain Diseases Antibodies  >8 publications with SERPING1 and Brain Diseases
 Necrosis Antibodies  >7 publications with SERPING1 and Necrosis
 Heart Diseases Antibodies  >5 publications with SERPING1 and Heart Diseases
 Kidney Diseases Antibodies  >4 publications with SERPING1 and Kidney Diseases
Organs/Tissues associated with anti-SERPING1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >77 publications with SERPING1 and Blood
 Vascular Antibodies  >24 publications with SERPING1 and Vascular
 Skin Antibodies  >23 publications with SERPING1 and Skin
 Larynx Antibodies  >15 publications with SERPING1 and Larynx
 Eye Antibodies  >8 publications with SERPING1 and Eye
 Heart Antibodies  >6 publications with SERPING1 and Heart
 Intestine Antibodies  >5 publications with SERPING1 and Intestine
 Liver Antibodies  >5 publications with SERPING1 and Liver
 Kidney Antibodies  >4 publications with SERPING1 and Kidney
 Muscle Antibodies  >4 publications with SERPING1 and Muscle
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