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anti-CACUL1 antibody :: Rabbit C10orf46 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9211660
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C10orf46 (CACUL1), Polyclonal Antibody

★Popular Item★
 Also Known As   

C10orf46 Antibody (C-term)

 Product Synonym Names    CDK2-associated and cullin domain-containing protein 1; Cdk-associated cullin1; CACUL1; C10orf46; CAC1
 Product Gene Name   

anti-CACUL1 antibody

[Similar Products]
 Antibody/Peptide Pairs    C10orf46 peptide (MBS9225463) is used for blocking the activity of C10orf46 antibody (MBS9211660)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    326-354
 3D Structure    ModBase 3D Structure for Q86Y37
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse (Predicted Reactivity: Rat)
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 Specificity    This C10orf46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-354 amino acids from the C-terminal region of human C10orf46.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
 Function    Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.
  Tissue Location    Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again in S/G2 phase
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-CACUL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CACUL1 antibody    Cell Biology
 Applications Tested/Suitable for anti-CACUL1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CACUL1 antibody    WB~~1:1000
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 Western Blot (WB) of anti-CACUL1 antibody    (LEFT)Western blot analysis of C10orf46 Antibody (C-term) in A375 cell line lysates (35ug/lane).C10orf46 (arrow) was detected using the purified Pab.
(RIGHT)Western blot analysis of C10orf46 Antibody (C-term) in mouse cerebellum tissue lysates (35ug/lane).C10orf46 (arrow) was detected using the purified Pab.
anti-CACUL1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CACUL1. It may not necessarily be applicable to this product.
 NCBI GI #    109452597
 NCBI GeneID    143384
 NCBI Accession #    NP_722517.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_153810.4 [Other Products]
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 UniProt Primary Accession #    Q86Y37 [Other Products]
 UniProt Secondary Accession #    Q5XPL7; Q8IY11; Q8N7S4 [Other Products]
 UniProt Related Accession #    Q86Y37 [Other Products]
 Molecular Weight    41064
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 NCBI Official Full Name    CDK2-associated and cullin domain-containing protein 1
 NCBI Official Synonym Full Names    CDK2-associated, cullin domain 1
 NCBI Official Symbol    CACUL1 [Similar Products]
 NCBI Official Synonym Symbols   
CAC1; C10orf46
[Similar Products]
 NCBI Protein Information    CDK2-associated and cullin domain-containing protein 1
 UniProt Protein Name    CDK2-associated and cullin domain-containing protein 1
 UniProt Synonym Protein Names   
Cdk-associated cullin1
 Protein Family    CDK2-associated and cullin domain-containing protein
 UniProt Gene Name    CACUL1 [Similar Products]
 UniProt Synonym Gene Names    C10orf46; CAC1 [Similar Products]
 UniProt Entry Name    CACL1_HUMAN
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 UniProt Comments for CACUL1    CACUL1: Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition. Belongs to the cullin family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 10q26.11

Cellular Component: cullin-RING ubiquitin ligase complex

Molecular Function: protein binding; ubiquitin protein ligase binding; protein kinase binding

Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of protein kinase activity; positive regulation of cell proliferation; G1/S transition of mitotic cell cycle
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Product References and Citations for anti-CACUL1 antibody

   Kong, Y., et al. Cell Cycle 8(21):3544-3553(2009)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
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 Research Articles on CACUL1    1. H. pylori-triggered CACUL1 production occurred in an activating protein 1-dependent manner and regulated matrix metalloproteinase 9 and Slug expression to affect the invasion and metastasis of tumor cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CACUL1 antibodyOrgans/Tissues associated with anti-CACUL1 antibody
 Reference Product  PubMed Publications
 CDK2 antibody  >3 publications with CACUL1 and CDK2
 Organ/Tissue Name  Pubmed Publications
 Stomach Antibodies  >2 publications with CACUL1 and Stomach
 Intestine Antibodies  >1 publications with CACUL1 and Intestine
 Lung Antibodies  >1 publications with CACUL1 and Lung
 Brain Antibodies  >1 publications with CACUL1 and Brain
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