AAH16284.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
C1D nuclear receptor co-repressor
NCBI Official Synonym Full Names
C1D nuclear receptor corepressor
NCBI Protein Information
nuclear nucleic acid-binding protein C1D; C1D DNA-binding protein; nuclear DNA-binding protein; C1D nuclear receptor co-repressor; small unique nuclear receptor corepressor; small unique nuclear receptor co-repressor
UniProt Protein Name
Nuclear nucleic acid-binding protein C1D
UniProt Synonym Gene Names
UniProt Entry Name
C1D_HUMAN
NCBI Summary for C1D
The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]
UniProt Comments for C1D
C1D: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. Belongs to the C1D family.
Protein type: Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor; DNA-binding
Chromosomal Location of Human Ortholog: 2p13-p12
Cellular Component: transcriptional repressor complex; cytoplasm; nucleolus; nucleus; nuclear exosome (RNase complex)
Molecular Function: ligand-dependent nuclear receptor binding; protein binding; DNA binding; RNA binding; transcription corepressor activity
Biological Process: maturation of 5.8S rRNA; transcription, DNA-dependent; apoptosis; negative regulation of transcription, DNA-dependent
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Products associated with anti-C1D antibody
Pathways associated with anti-C1D antibody
Diseases associated with anti-C1D antibody
Organs/Tissues associated with anti-C1D antibody
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