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| Product Name
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C4orf49 (MGARP), Polyclonal Antibody
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| Also Known As
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C4orf49, CT (MGARP, C4orf49, CESP1, HUMMR, OSAP, Protein MGARP, Corneal endothelium-specific protein 1, Hypoxia up-regulated mitochondrial movement regulator protein, Mitochondria-localized glutamic acid-rich protein, Ovary-specific acidic protein)
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| Product Synonym Names
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Anti -C4orf49, CT (MGARP, C4orf49, CESP1, HUMMR, OSAP, Protein MGARP, Corneal endothelium-specific protein 1, Hypoxia up-regulated mitochondrial movement regulator protein, Mitochondria-localized glutamic acid-rich protein, Ovary-specific acidic protein)
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Chromosome Location
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Chromosome: 4; NC_000004.11 (140187317..140201492, complement). Location: 4q31.1
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| 3D Structure
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ModBase 3D Structure for Q8TDB4
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| Clonality
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Polyclonal
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| Isotype
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IgG
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| Host
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Rabbit
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| Species Reactivity
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Human
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| Specificity
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Human
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| Purity/Purification
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Affinity Purified
Purified by Protein A affinity chromatography.
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| Form/Format
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Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
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| Immunogen
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C4orf49 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-204 amino acids from the C-terminal region of human C4orf49.
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| Preparation and Storage
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May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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| Other Notes
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Small volumes of anti-MGARP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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The function of this protein remains unknown.
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| Product Categories/Family for anti-MGARP antibody
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Antibodies; Abs to Mitochondrial Proteins
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| Applications Tested/Suitable for anti-MGARP antibody
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ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
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| Application Notes for anti-MGARP antibody
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Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50
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TOP
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| NCBI/Uniprot data below describe general gene information for MGARP. It may not necessarily be applicable to this product. |
| NCBI GI #
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74355769
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| NCBI GeneID
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84709
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| NCBI Accession #
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AAI04174.1
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[Other Products]
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| UniProt Primary Accession #
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Q8TDB4
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[Other Products]
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| UniProt Secondary Accession #
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Q9BZC3
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[Other Products]
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| UniProt Related Accession #
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Q8TDB4
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[Other Products]
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| Molecular Weight
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25,390 Da
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[Similar Products]
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TOP
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| NCBI Official Full Name
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Chromosome 4 open reading frame 49
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| NCBI Official Synonym Full Names
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mitochondria-localized glutamic acid-rich protein
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| NCBI Official Symbol
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MGARP
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[Similar Products]
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| NCBI Official Synonym Symbols
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OSAP; HUMMR; CESP-1; C4orf49
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[Similar Products]
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| NCBI Protein Information
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protein MGARP; ovary-specific acidic protein; corneal endothelium-specific protein 1; hypoxia up-regulated mitochondrial movement regulator protein
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| UniProt Protein Name
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Protein MGARP
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| UniProt Synonym Protein Names
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Corneal endothelium-specific protein 1; CESP-1; Hypoxia up-regulated mitochondrial movement regulator protein; Mitochondria-localized glutamic acid-rich protein; Ovary-specific acidic protein
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| Protein Family
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Protein
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| UniProt Gene Name
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MGARP
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[Similar Products]
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| UniProt Synonym Gene Names
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C4orf49; CESP1; HUMMR; OSAP; CESP-1
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[Similar Products]
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| UniProt Entry Name
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HUMMR_HUMAN
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| UniProt Comments for MGARP
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OSAP: Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q31.1
Cellular Component: mitochondrion; integral to mitochondrial outer membrane
Molecular Function: protein binding
Biological Process: axon transport of mitochondrion; anterograde axon cargo transport; retrograde axon cargo transport; protein targeting to mitochondrion
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TOP
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| Research Articles on MGARP
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1. The present study identified a proximal core sequence in the MGARP promoter that is composed of two enriched Sp1 binding motifs and established Sp1 as one major MGARP transactivator.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Organs/Tissues associated with anti-MGARP antibody |
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TOP
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Antibody 
